ID F7BVA4_HORSE Unreviewed; 564 AA.
AC F7BVA4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=WSC domain containing 2 {ECO:0000313|Ensembl:ENSECAP00000017303.2};
GN Name=WSCD2 {ECO:0000313|Ensembl:ENSECAP00000017303.2,
GN ECO:0000313|VGNC:VGNC:58275};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017303.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000017303.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017303.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000017303.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017303.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sialate:O-sulfotransferase which catalyzes 8-O-sulfation at
CC the Sia-glycan level using 3'-phosphoadenosine 5'-phosphosulfate (PAPS)
CC as a donor, forming 8-O-sulfated Sia (Sia8S)-glycans.
CC {ECO:0000256|ARBA:ARBA00035001}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004323}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004323}.
CC -!- SIMILARITY: Belongs to the WSCD family.
CC {ECO:0000256|ARBA:ARBA00010236}.
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DR AlphaFoldDB; F7BVA4; -.
DR SMR; F7BVA4; -.
DR STRING; 9796.ENSECAP00000017303; -.
DR PaxDb; 9796-ENSECAP00000017303; -.
DR Ensembl; ENSECAT00000021033.3; ENSECAP00000017303.2; ENSECAG00000019805.3.
DR VGNC; VGNC:58275; WSCD2.
DR GeneTree; ENSGT00940000159434; -.
DR HOGENOM; CLU_029239_0_0_1; -.
DR InParanoid; F7BVA4; -.
DR OMA; ERSNTCG; -.
DR OrthoDB; 3971278at2759; -.
DR TreeFam; TF324060; -.
DR Proteomes; UP000002281; Chromosome 8.
DR Bgee; ENSECAG00000019805; Expressed in cerebellum and 11 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002889; WSC_carb-bd.
DR PANTHER; PTHR45964:SF7; WSC DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45964; WSCD FAMILY MEMBER CG9164; 1.
DR Pfam; PF01822; WSC; 2.
DR SMART; SM00321; WSC; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51212; WSC; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 126..218
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
FT DOMAIN 229..323
FT /note="WSC"
FT /evidence="ECO:0000259|PROSITE:PS51212"
SQ SEQUENCE 564 AA; 63754 MW; 27DFF10E11234889 CRC64;
MAKLWFKFQR HFRRKPVRFF TFLVLYLTAG SLVFLHSGFV GQPAVSQNQA NPAAGVPAEG
AELPFLGDLH LGRGFRDAGE ASSIARRYGP WFKGKDGNER AKLGDYGGAW SRALKGRVVR
EKEEERAKYI GCYLDDTQSR ALRGVSFFDY KKMTIFRCQD NCAERGYLYA GLEFGAECYC
GHKIQATNVS EAECDMECKG ERGSVCGGAN RLSVYRLQLA QESARRYGSA VFRGCFRRPN
NLSLALPVTA AMPNMSVDKC VDLCTEKEYP LAALAGTACH CGFPTTRFPL HEREDEQLCA
QKCSAEEFES CGTPSYFIVY QTQVQDNRCM DRRFLPAKSE QLIALASFPG AGNTWARHLI
ELATGFYTGS YYFDGSLYNK GFKGERDHWR SGRTICIKTH ESGQKEIEAF DAAILLIRNP
YKALMAEFNR KYGGHIGFAA HAHWKGKEWP EFVRNYAPWW ATHTLDWLQF GKKVLVVHFE
DLKEDLFVQL GRMVGLLGVA VREDRLLCVE SQKDGNFKRS GLRKLEYDPY TADMQKTISA
YIKVVDAALK GRNLTGVPDD YYPR
//
