ID   F7BVB1_HORSE            Unreviewed;       539 AA.
AC   F7BVB1;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   13-SEP-2023, sequence version 3.
DT   27-MAR-2024, entry version 54.
DE   SubName: Full=Kelch domain containing 4 {ECO:0000313|Ensembl:ENSECAP00000017302.3};
GN   Name=KLHDC4 {ECO:0000313|Ensembl:ENSECAP00000017302.3,
GN   ECO:0000313|VGNC:VGNC:49395};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017302.3, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000017302.3, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017302.3,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA   Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA   Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA   Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA   Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA   Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA   Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA   Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA   Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000017302.3}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017302.3};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; F7BVB1; -.
DR   STRING; 9796.ENSECAP00000017302; -.
DR   PaxDb; 9796-ENSECAP00000017302; -.
DR   Ensembl; ENSECAT00000021032.3; ENSECAP00000017302.3; ENSECAG00000019667.4.
DR   VGNC; VGNC:49395; KLHDC4.
DR   GeneTree; ENSGT00390000003374; -.
DR   HOGENOM; CLU_008722_3_1_1; -.
DR   InParanoid; F7BVB1; -.
DR   OMA; HIYNIAR; -.
DR   TreeFam; TF323290; -.
DR   Proteomes; UP000002281; Chromosome 3.
DR   ExpressionAtlas; F7BVB1; baseline.
DR   Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR   InterPro; IPR015915; Kelch-typ_b-propeller.
DR   PANTHER; PTHR46063; KELCH DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR46063:SF1; KELCH DOMAIN-CONTAINING PROTEIN 4; 1.
DR   Pfam; PF13415; Kelch_3; 2.
DR   Pfam; PF13418; Kelch_4; 1.
DR   SUPFAM; SSF117281; Kelch motif; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          353..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          442..494
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        11..33
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        442..478
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   539 AA;  60663 MW;  E3D221AA83CB9885 CRC64;
     MGKKGKKEKK GRGAEKTAAK MEKKVSKRSR KEEEDLEALI AHFQTLDAKK TQVVETPCPP
     PSPRLNASLS AHPEKDELIL FGGEYFNGQK TLLYNELYIY NIRKDSWTRV EIPSAPPRRC
     AHQAVVVPQG GGQVWIFGGE FASPDGEQFY HYKDLWVLHL ATRTWEQVRS PGGPSGRSGH
     RMVAWKRQLI LFGGFHESTR DYIYYNDVYA FNLDTFTWSK LSPSGTGPTP RSGCQMTVTP
     QGSIVIYGGY SKQRVKKDVD RGTQHADMFL LKSEEGGEGR WTWTRINPSG AKPSPRSGFS
     VAVAPNHQTL LFGGVCDEEE EESLQGDFLN DLYFYDAAKN RWFAGQLKGP KLEKRKRRRG
     KKVEPEGRPQ SDEEDGPDEA ESPTIEPSPR SNAMLAVKHG RLYLYGGMFE AGNRQVTLSD
     LYCLDLHKME EWTALVEMDP ETQEWLEETD SEEDSDAVEG AEGRGEDEED EDSGEDSGEE
     GGEQHHPLVR PGEQFADYLP RTEQYWVQLA RDATRPGAQE KSVLRAAHAT ARAFFDDSA
//