ID F7BVU0_MONDO Unreviewed; 1171 AA.
AC F7BVU0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Laminin subunit beta 3 {ECO:0000313|Ensembl:ENSMODP00000003017.2};
GN Name=LAMB3 {ECO:0000313|Ensembl:ENSMODP00000003017.2};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000003017.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000003017.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000003017.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR RefSeq; XP_007481387.1; XM_007481325.1.
DR RefSeq; XP_007481388.1; XM_007481326.2.
DR AlphaFoldDB; F7BVU0; -.
DR STRING; 13616.ENSMODP00000003017; -.
DR Ensembl; ENSMODT00000003082.3; ENSMODP00000003017.2; ENSMODG00000002485.3.
DR GeneID; 100021649; -.
DR KEGG; mdo:100021649; -.
DR CTD; 3914; -.
DR eggNOG; KOG0994; Eukaryota.
DR GeneTree; ENSGT00940000160731; -.
DR HOGENOM; CLU_001560_0_0_1; -.
DR InParanoid; F7BVU0; -.
DR OMA; RCLCLPH; -.
DR OrthoDB; 90222at2759; -.
DR TreeFam; TF352481; -.
DR Proteomes; UP000002280; Chromosome 2.
DR Bgee; ENSMODG00000002485; Expressed in placenta and 17 other cell types or tissues.
DR GO; GO:0043256; C:laminin complex; IBA:GO_Central.
DR GO; GO:0005610; C:laminin-5 complex; IEA:Ensembl.
DR GO; GO:0009887; P:animal organ morphogenesis; IBA:GO_Central.
DR GO; GO:0070831; P:basement membrane assembly; IBA:GO_Central.
DR GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:0035987; P:endodermal cell differentiation; IEA:Ensembl.
DR GO; GO:0034446; P:substrate adhesion-dependent cell spreading; IBA:GO_Central.
DR GO; GO:0009888; P:tissue development; IBA:GO_Central.
DR CDD; cd22303; cc_LAMB3_C; 1.
DR CDD; cd00055; EGF_Lam; 6.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF268; LAMININ SUBUNIT BETA-3; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 6.
DR Pfam; PF00055; Laminin_N; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00180; EGF_Lam; 6.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 5.
DR PROSITE; PS01248; EGF_LAM_1; 2.
DR PROSITE; PS50027; EGF_LAM_2; 6.
DR PROSITE; PS51117; LAMININ_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1171
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003349769"
FT DOMAIN 21..248
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 249..314
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 315..377
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 378..429
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 430..479
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 480..532
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 533..579
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT REGION 744..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 831..872
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 948..1055
FT /evidence="ECO:0000256|SAM:Coils"
FT DISULFID 280..289
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 345..354
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 400..409
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 452..461
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 480..492
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 482..499
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 501..510
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 533..545
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 535..552
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 554..563
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1171 AA; 129735 MW; CD02EE95370A1D09 CRC64;
MWPLLMLMAL PGLLHAQQAC SRGACYPPVG DLLVGRTRFL KASSTCGITK PETYCTPYGE
WKMKCCKCDS RLPHGYNSHR VENVVSSSGP MRWWQSQNDV SPVSLQLNLD RKFQLQDIKL
DLQGPLPAGM LIERSPDFGK TWKVYQYLAP NCAATFPHLR QGRPQNWQDV RCQPLSAQHT
GPNRGGKVHL NLLDLASGIP ASQSQKIREL GEITNLRVNL TTLDPVPQMR FHSPSDYFAV
SHLRLQGSCL CHGHADRCAP LPGTPADPSA RVQVHEVCVC QHNTAGPNCD RCAPFYNNQP
WKPADDQNPH ECQRCDCNGH SETCHFDPAV FAASQGVSGG VCDNCRDHTE GKNCERCQLH
YFRNRRPGVP IQETCIPCEC DPDGAVPGAP CDPLTGQCVC KENVQGERCD LCKPGFTGLT
HANPQGCSRC DCSILGSRRD MPCDEETGRC LCLPNVVGPK CDQCAPHYWK VASGRGCEPC
NCDPRNSYGP QCNQFTGQCP CREGFEGPTC SAMSIRLCPD RTFGDTGTEC RACDCDFRGT
EGPGCDKATG RCLCRPGFVG PRCDQCQRGF CDNYPVCVAC HPCFQKYDRN LREEAFRLRA
LVNTTAGLRP GSSPGAHGLG PQIVEAENSI RQIQAMLRTP SVTEQEITEV ANDIFSVRRM
LQSLRTDLPL EEETDSLSGE LENLDRSLKL LLIQYQNKRE QFERISSTDP SGSLRMLTSA
YQMSSQAAQR IASSSNLLLQ AHDSRREAER LERQVEGSGS AGGPQLQTLR QQMASFPNLT
PTINKICGTT RQDTCTPGQC QGILCPRDNG TTCDPDCRGT LHRAGSAFRT AKQVSQQLQD
FNAQLQQTKQ MIRAAEEAAT QIQTDAQLLE TQVSNSRSQM EEDVRRTRIL IQQVRDFLTD
PSTDAATIQE ISESVLALWL PTDSATVLRK MNEIQAIAAR LPNVDLVLSQ TKQDVARARK
LQEEAELARS RAIAVEGQVE DVVGNLRQGT VALQEAEDTM QGTRRSLGLL QDRITEVQQV
LAPTERMVTG MTEQLSSFRD RIEQLRLKVG EQRAQSAQAQ KIAQGANEQA LSAQQGFERV
KQKYAELKDQ MGQSPMLGEQ GTRILSVKAE AEELFEETMS MMDRMKAMEA ELLLGSQAIT
LRSADLTGLE KHVEKIRDHI NKRVLYYATC Q
//
