ID F7C362_HORSE Unreviewed; 345 AA.
AC F7C362;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Transcription factor 19 {ECO:0000313|Ensembl:ENSECAP00000005924.3};
GN Name=TCF19 {ECO:0000313|Ensembl:ENSECAP00000005924.3,
GN ECO:0000313|VGNC:VGNC:23948};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000005924.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000005924.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005924.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000005924.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005924.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_001489228.1; XM_001489178.3.
DR AlphaFoldDB; F7C362; -.
DR STRING; 9796.ENSECAP00000005924; -.
DR PaxDb; 9796-ENSECAP00000005924; -.
DR Ensembl; ENSECAT00000007981.3; ENSECAP00000005924.3; ENSECAG00000007872.3.
DR GeneID; 100054623; -.
DR KEGG; ecb:100054623; -.
DR VGNC; VGNC:23948; TCF19.
DR GeneTree; ENSGT00390000015391; -.
DR HOGENOM; CLU_041089_0_0_1; -.
DR InParanoid; F7C362; -.
DR OMA; MQFNRFH; -.
DR TreeFam; TF334697; -.
DR Proteomes; UP000002281; Chromosome 20.
DR Bgee; ENSECAG00000007872; Expressed in bone marrow and 22 other cell types or tissues.
DR ExpressionAtlas; F7C362; baseline.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR CDD; cd22685; FHA_TCF19; 1.
DR CDD; cd15609; PHD_TCF19; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR042803; TCF19.
DR InterPro; IPR039095; TCF19_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR15464; TRANSCRIPTION FACTOR 19; 1.
DR PANTHER; PTHR15464:SF1; TRANSCRIPTION FACTOR 19; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 31..88
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT REGION 138..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..215
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 345 AA; 37175 MW; D58CA6106895BE7B CRC64;
MLPCFQLLRI GGGRGGDLYT FHPPSEAGCT YRLGHRADLC DVALRPQQEP GLISGVHAEL
HAERWGDDWR VSLEDHSSQG TLVNNVRLPR GHRLELSDGD LLTFGPEGPP GTSPSEFYFM
FQQVRVKPQD FAAITIPRSR GEEGTGAGFR PMLPSQGAPQ RPLSTLSPAP KATLILNSIG
SLSKLQPQPL TFSRSGGGPQ SLPVPTPPGE VGTTPSAPPP RNRRKSAHRV LAELDDEREA
PESPPPVLME PRKKLRVEKT PLTPSGNRRG RPRKHPVSTP MAPPAVGGGE PCAAPCCCLP
QEETVAWVQC DGCDVWFHVA CVGCSIQAAR EADFRCPGCR IGIPT
//
