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Database: UniProt
Entry: F7C9P6_ORNAN
LinkDB: F7C9P6_ORNAN
Original site: F7C9P6_ORNAN 
ID   F7C9P6_ORNAN            Unreviewed;       434 AA.
AC   F7C9P6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   24-JAN-2024, entry version 50.
DE   RecName: Full=Argininosuccinate lyase {ECO:0000256|ARBA:ARBA00019698};
GN   Name=ASL {ECO:0000313|Ensembl:ENSOANP00000025876.2};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000025876.2, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000025876.2, ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000025876.2,
RC   ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA   Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA   Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA   Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA   Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA   Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA   Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA   Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA   Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA   Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA   Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA   Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA   Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA   Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA   Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA   de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000025876.2}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000025876.2};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-(N(omega)-L-arginino)succinate = fumarate + L-arginine;
CC         Xref=Rhea:RHEA:24020, ChEBI:CHEBI:29806, ChEBI:CHEBI:32682,
CC         ChEBI:CHEBI:57472; EC=4.3.2.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00033644};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24021;
CC         Evidence={ECO:0000256|ARBA:ARBA00033644};
CC       PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:24022;
CC         Evidence={ECO:0000256|ARBA:ARBA00033644};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004730}.
CC   -!- PATHWAY: Nitrogen metabolism; urea cycle; L-arginine and fumarate from
CC       (N(omega)-L-arginino)succinate: step 1/1.
CC       {ECO:0000256|ARBA:ARBA00005214}.
CC   -!- SIMILARITY: Belongs to the lyase 1 family. Argininosuccinate lyase
CC       subfamily. {ECO:0000256|ARBA:ARBA00010755}.
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DR   AlphaFoldDB; F7C9P6; -.
DR   Ensembl; ENSOANT00000029680.3; ENSOANP00000025876.2; ENSOANG00000020360.3.
DR   GeneTree; ENSGT00950000183122; -.
DR   HOGENOM; CLU_027272_1_0_1; -.
DR   UniPathway; UPA00068; -.
DR   UniPathway; UPA00158; UER00273.
DR   Proteomes; UP000002279; Chromosome 17.
DR   Bgee; ENSOANG00000020360; Expressed in liver and 7 other cell types or tissues.
DR   GO; GO:0004056; F:argininosuccinate lyase activity; IEA:InterPro.
DR   GO; GO:0042450; P:arginine biosynthetic process via ornithine; IEA:InterPro.
DR   GO; GO:0000050; P:urea cycle; IEA:UniProtKB-UniPathway.
DR   CDD; cd01359; Argininosuccinate_lyase; 1.
DR   Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 2.
DR   Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR   HAMAP; MF_00006; Arg_succ_lyase; 1.
DR   InterPro; IPR029419; Arg_succ_lyase_C.
DR   InterPro; IPR009049; Argininosuccinate_lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR020557; Fumarate_lyase_CS.
DR   InterPro; IPR000362; Fumarate_lyase_fam.
DR   InterPro; IPR022761; Fumarate_lyase_N.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   NCBIfam; TIGR00838; argH; 1.
DR   PANTHER; PTHR43814; ARGININOSUCCINATE LYASE; 1.
DR   PANTHER; PTHR43814:SF1; ARGININOSUCCINATE LYASE; 1.
DR   Pfam; PF14698; ASL_C2; 1.
DR   Pfam; PF00206; Lyase_1; 2.
DR   PRINTS; PR00145; ARGSUCLYASE.
DR   PRINTS; PR00149; FUMRATELYASE.
DR   SUPFAM; SSF48557; L-aspartase-like; 1.
DR   PROSITE; PS00163; FUMARATE_LYASES; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Urea cycle {ECO:0000256|ARBA:ARBA00022436}.
FT   DOMAIN          7..170
FT                   /note="Fumarate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00206"
FT   DOMAIN          170..275
FT                   /note="Fumarate lyase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00206"
FT   DOMAIN          338..405
FT                   /note="Argininosuccinate lyase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF14698"
SQ   SEQUENCE   434 AA;  48416 MW;  2FA2454747C9375A CRC64;
     GNKLWGGRFV GSVDPIMERF NSSIHYDRRM WEADIQGSKA YSKGLEKAGL LTKAELEKIL
     SGLDKVAEEW SAGTFMVSPN DEDIHTANER RLKELIGEAA GKLHTGRSRN DQVVTDLRLW
     MRQACTTLST HLLELIRTMV ERAAAEQDVL FPGYTHLQRA QPIRWSHWIL SGAIAGNPLG
     VDRELLRKEL SFGAITLNSM DATSERDFVA EFLFWASLCM THLSKVAEDL ILYGTKEFSF
     VQLSDAYSTG SSLMPQKKNP DSLELIRSKA GRVFGRCAGL MVTLKGLPST YNKDLQEDKE
     AVFDVFDTVS SVLQVATGVI STLQINKDSM ERALSPDMLA TDLAYYLVRK GMPFRQAHGA
     SGKAVYLAET KGVTLNHLSL QDLQTISPLF ASDVSQVWNY ANSVEQYTAL GGTARSSVDW
     QIQQLRSLLQ RHRD
//
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