ID F7CC92_XENTR Unreviewed; 541 AA.
AC F7CC92;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE SubName: Full=Signal transducing adaptor molecule {ECO:0000313|Ensembl:ENSXETP00000002899};
GN Name=stam {ECO:0000313|Ensembl:ENSXETP00000002899};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000002899};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000002899}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000002899};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000002899}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004469}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004469}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004469}.
CC -!- SIMILARITY: Belongs to the STAM family.
CC {ECO:0000256|ARBA:ARBA00009666}.
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DR AlphaFoldDB; F7CC92; -.
DR Ensembl; ENSXETT00000002899; ENSXETP00000002899; ENSXETG00000001364.
DR AGR; Xenbase:XB-GENE-482429; -.
DR Xenbase; XB-GENE-482429; stam.
DR HOGENOM; CLU_010104_0_2_1; -.
DR InParanoid; F7CC92; -.
DR Reactome; R-XTR-182971; EGFR downregulation.
DR Reactome; R-XTR-5689901; Metalloprotease DUBs.
DR Reactome; R-XTR-6807004; Negative regulation of MET activity.
DR Reactome; R-XTR-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-XTR-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-XTR-9013420; RHOU GTPase cycle.
DR Reactome; R-XTR-917729; Endosomal Sorting Complex Required For Transport (ESCRT).
DR Bgee; ENSXETG00000001364; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd21389; GAT_STAM1; 1.
DR CDD; cd11964; SH3_STAM1; 1.
DR CDD; cd17000; VHS_STAM1; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 6.10.140.100; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR047492; GAT_STAM1.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035657; STAM1_SH3.
DR InterPro; IPR003903; UIM_dom.
DR InterPro; IPR002014; VHS_dom.
DR InterPro; IPR047528; VHS_STAM1.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF2; SIGNAL TRANSDUCING ADAPTER MOLECULE 1; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF02809; UIM; 1.
DR Pfam; PF00790; VHS; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00726; UIM; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50330; UIM; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 16..143
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 208..267
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 437..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 541 AA; 59442 MW; D836DADF4459ED08 CRC64;
MPLFTSNPFD PDVEKATSEL NTAEDWGLIL DLCDKVGQSR TGPKDCLRSI MRRVNHKDPH
VAMQALTLLG ACVSNCGKIF HLEVCSRDFA SEVSSVLNKG HPKVCEKLKA LMVEWADEFK
NDPQLSLISA MIKNLKEQGV TFPAVGSQAA DQAKASPALV AKDPGTAATK KEEEDLAKAI
ELSLKEQKQQ STVSGLYPSS SLLSALKPEG RKVQAIYDFE AAEDNELTFK AGDIVTVLDD
SDPNWWKGET NEGIGLFPSN FVTADLTAEL EMIKTEKKTV QFSDEVQVET IEPEPEPVYI
DEDKMDHLLQ MLQSADPTDG LPDPTDLLHL EAACHQMGPL IDEKLEDIDR KHSELSELNV
KVMEALSLYT KLMNEDPMYS MYAKMQNQQF YMQSAAVPPQ QSYQGPHPNA AYLVTGNAQM
GHIQTYPIPT EQLPSLNQGA VPHPASNELP SQSPQASYNT TVISSTPGNL YMNQATGHSL
NPAASAAPID ITAYQNGIGA PQQPLWHFTT CLNKSQSSLQ HTSELITMMC NHPNDPSQYE
P
//
