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Database: UniProt
Entry: F7CH19_CALJA
LinkDB: F7CH19_CALJA
Original site: F7CH19_CALJA 
ID   F7CH19_CALJA            Unreviewed;       792 AA.
AC   F7CH19;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   07-JUN-2017, entry version 30.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=TCIRG1 {ECO:0000313|Ensembl:ENSCJAP00000028924};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000028924, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000028924, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000028924}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000028924}.
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DR   EMBL; ACFV01145046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01145047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01145048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01145049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000030565; ENSCJAP00000028924; ENSCJAG00000015705.
DR   GeneTree; ENSGT00390000004941; -.
DR   OrthoDB; EOG091G031W; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000008225; Chromosome 11.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0016236; P:macroautophagy; IEA:Ensembl.
DR   GO; GO:0007039; P:protein catabolic process in the vacuole; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    387    412       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    433    450       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    511    529       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    536    554       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    574    592       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    599    618       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    630    655       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    739    758       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   792 AA;  88669 MW;  DC8786A8610E7C18 CRC64;
     MGSMFRSEEV ALVQLFLPTA AAYTCVSRLG ELGLVEFRDL NASVSAFQRR FVVDVRRCEE
     LEKTFTFLQE EVQRAGLVLP PPEGRLPAPP PRDLLRIQEE TERLAQELRD VRGNQQALRV
     QLHQLQLHAA VLGQGHSPQP PTHMGLGEAP LLRLLGAHRT FVAGAVEPHK APALERLLWR
     ACRGFLIASF RELERPLEHP VTGEPATWMT FLISYWGEQI GQKIRKITDC FHCHIFPFLE
     QEEARRAALQ QQSQELQEVL GETERFLSQV LGRVQQLLPP AQVQVRKMKA VYLALNQCSM
     STTHKCLIAE TWCAARDLPA LQEALRDSSM EEGVSAVAHR IPSRDMPPTL IRTNRFTASF
     QGIVDAYGVG RYQEVNPAPY TIVTFPFLFA VMFGDVGHGL LMFLFALAMV LAENRPAMKA
     AQNEIWQTFF GGRYLLLLMG LFSVYTGFIY NECFSRASSI FPSGWSVAAM ANQSGWSPDR
     PALHCHSDAF LAQHTMLTLD PNVTGVFLGP YPFGIDPIWS LAANHLSFLN SFKMKMSVIL
     GVVHMAFGVV LGVFNHMHFG QRHRLLLETL PELTFLLGLF GYLVFLVIYK WLRVSATNAA
     SAPSILIHFI NMFLFSHSPT NRPLYPRQEV VQAMLVVLAL AMVPVLLLGT PLHLLHRHRR
     RRRRPTGRKQ RCLLLPQQED KAGLLGLPDA SVNCWGSDEE KAGGLEDEQE AERCSCTRPS
     TPIEFCLGCV SNTVSYLRLW ALSLATSAVM TVAILLVMEG LSTSACPEAA LVEFQNKFYS
     GTGYKLSPFT FA
//
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