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Database: UniProt
Entry: F7CHK4_CALJA
LinkDB: F7CHK4_CALJA
Original site: F7CHK4_CALJA 
ID   F7CHK4_CALJA            Unreviewed;       725 AA.
AC   F7CHK4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   05-JUL-2017, entry version 22.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=TCIRG1 {ECO:0000313|Ensembl:ENSCJAP00000028914};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000028914, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000028914, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000028914}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000028914}.
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DR   EMBL; ACFV01145046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01145047; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01145048; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01145049; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000030555; ENSCJAP00000028914; ENSCJAG00000015705.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   Proteomes; UP000008225; Chromosome 11.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    395    420       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    441    458       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    509    527       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    534    552       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    572    590       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    597    616       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    628    653       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   725 AA;  81370 MW;  628639B70093EC74 CRC64;
     MGSMFRSEEV ALVQLFLPTA AAYTCVSRLG ELGLVEFRDL NASVSAFQRR FVVDVRRCEE
     LEKTFTFLQE EVQRAGLVLP PPEGRLPAPP PRDLLRIQEE TERLAQELRD VRGNQQALRV
     QLHQLQLHAA VLGQGHSPQV SSSPXXEASE RTPLLQALRG RTSPVAASFV AGAVEPHKAP
     ALERLLWRAC RGFLIASFRE LERPLEHPVT GEPATWMTFL ISYWGEQIGQ KIRKITDCFH
     CHIFPFLEQE EARRAALQQQ SQELQEVLGE TERFLSQVLG RVQQLLPPAQ VQVRKMKAVY
     LALNQCSMST THKCLIAETW CAARDLPALQ EALRDSSMEE GVSAVAHRIP SRDMPPTLIR
     TNRFTASFQG IVDAYGVGRY QEVNPAPYTI VTFPFLFAVM FGDVGHGLLM FLFALAMVLA
     ENRPAMKAAQ NEIWQTFFGG RYLLLLMGLF SVYTGFIYNE CFSRASSIFP SGWSVAAMAN
     QSGWSDAFLA QHTMLTLDPN VTGVFLGPYP FGIDPIWSLA ANHLSFLNSF KMKMSVILGV
     VHMAFGVVLG VFNHMHFGQR HRLLLETLPE LTFLLGLFGY LVFLVIYKWL RVSATNAASA
     PSILIHFINM FLFSHSPTNR PLYPRQEVVQ AMLVVLALAM VPVLLLGTPL HLLHRHRRRR
     RRPTGRKQED KAGLLGLPDA SVNCWGSDEE KAGGLEDEQE AEVVPSEVFM HQAIHTHRVL
     PGLRL
//
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