ID F7CLQ0_ORNAN Unreviewed; 760 AA.
AC F7CLQ0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Acylamino-acid-releasing enzyme {ECO:0000256|ARBA:ARBA00018421};
DE EC=3.4.19.1 {ECO:0000256|ARBA:ARBA00012917};
DE AltName: Full=Acyl-peptide hydrolase {ECO:0000256|ARBA:ARBA00032596};
DE AltName: Full=Acylaminoacyl-peptidase {ECO:0000256|ARBA:ARBA00032284};
GN Name=APEH {ECO:0000313|Ensembl:ENSOANP00000011372.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000011372.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000011372.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011372.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000011372.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000011372.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N-
CC terminus of a polypeptide.; EC=3.4.19.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000721};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; F7CLQ0; -.
DR STRING; 9258.ENSOANP00000011372; -.
DR MEROPS; S09.004; -.
DR Ensembl; ENSOANT00000011374.3; ENSOANP00000011372.3; ENSOANG00000007146.4.
DR eggNOG; KOG2100; Eukaryota.
DR GeneTree; ENSGT00390000013172; -.
DR HOGENOM; CLU_014230_1_1_1; -.
DR InParanoid; F7CLQ0; -.
DR OMA; QEIATPF; -.
DR TreeFam; TF312937; -.
DR Proteomes; UP000002279; Chromosome X1.
DR Bgee; ENSOANG00000007146; Expressed in adult mammalian kidney and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0008242; F:omega peptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0050435; P:amyloid-beta metabolic process; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IEA:Ensembl.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR045550; AARE_N.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002471; Pept_S9_AS.
DR InterPro; IPR001375; Peptidase_S9.
DR PANTHER; PTHR42776:SF4; ACYLAMINO-ACID-RELEASING ENZYME; 1.
DR PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR Pfam; PF19283; APEH_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR PROSITE; PS00708; PRO_ENDOPEP_SER; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT DOMAIN 93..313
FT /note="Acylamino-acid-releasing enzyme N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19283"
FT DOMAIN 550..758
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 760 AA; 84563 MW; AACD50223A1A6E50 CRC64;
MERQVRARGR GRGPPRGPPA PGSLRSRPHP SVPAQVLAEP TEALAVYRRL SRYPALAAAS
VGPEVVTQYG GRYCPVQTEW LQRDLERMEA VRFCRQYLVF HDSGSVLFAG PAGTCTETKG
ELLSRESPSG LMKALLRKIS NNCTGEDKQF LEVWGKNSKL RTVNLTALEK HGPVYEDDCF
GCLSWSHSET HILYVAEKKR SKTESFFQAK PAEFSDETPR MKKEDSTVKG DQFVFHEDWG
ESLGSKSVPV LCVLDIDSGN ISVLEGIPGH ISPGQAIWAP RDTGVVFVGW WHEPFRLGVR
FCSNRRSALF YLNLTSGKCE PLTDDTKASW SPRLSPDQCH IVYLRYTTLG PHHQCSQLCL
LDWYSRLTTV IVDVVPRQSK GYFSGIYCNL LPLSCWSDDS QRVVFDSGNR SRQDLFSVDM
LTGSVIPLTS GFPAASWKLF TVQRDLLVAQ FSTPNCPPSL KVGFLPPPGK EQTICWMPLE
DAEPLIEIMW GIRALQPPPE QENPRYAGLD FEAILLEPNI PTGRKKIPLV VMPHGGPHSS
FVAGWMLFPA VLCKMGFAVL LVNYRGSSGF GQDSIFSLPG NVGDQDVKDV QFAVEQLLLE
EQFDSGRVAL MGGSHGGFLS CHLIGQYPEV YKACIARNPV INIASLSGST DIPDWCLVEA
GFPYRAEYLH DPAIWLEMLK KSPVCYISQV KTPVLLILGQ EDKRVPCKQG VAYYRALKAR
NVPVRVLLYP KSSHSLSEVE VESDSFMNTV VWLCKHLGTC
//
