ID F7CQ32_HORSE Unreviewed; 1878 AA.
AC F7CQ32;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=SET binding factor 2 {ECO:0000313|Ensembl:ENSECAP00000021048.3};
GN Name=SBF2 {ECO:0000313|Ensembl:ENSECAP00000021048.3,
GN ECO:0000313|VGNC:VGNC:22706};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000021048.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000021048.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021048.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000021048.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000021048.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR Ensembl; ENSECAT00000025304.3; ENSECAP00000021048.3; ENSECAG00000023537.5.
DR VGNC; VGNC:22706; SBF2.
DR GeneTree; ENSGT00940000155385; -.
DR HOGENOM; CLU_016440_0_0_1; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000023537; Expressed in spinal cord and 23 other cell types or tissues.
DR ExpressionAtlas; F7CQ32; baseline.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR CDD; cd14589; PTP-MTMR13; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF4; MYOTUBULARIN-RELATED PROTEIN 13; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 37..456
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1137..1613
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1772..1876
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1703..1723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1878 AA; 211097 MW; 073FC56DAB10B940 CRC64;
MPAGLGQDRR AGRVGAYCAK FLGDELLPCI LKSVGWGLPV VLVLCLKGSG AGLGKIIQRF
PQKDWDDTPF PQGIELFCQP SGWQLSRERK QPTFFVVVLT DIDSDRHYCS CLTFYEAEIN
LQGTKKEEIE GEVEVTGLIQ PAEVFAPKSL VLVSRLDYPD VFRACLGLIY TVYVDSLNVS
LESLIANLCA CLVPAAGGSQ KLFSLGAGDR QLIQTPLHDS LPVTGTSVAL LFQQLGIQNV
LSLFCAVLTE NKVLFHSASF QRLSDACRAL ESLMFPLKYS YPYIPILPAQ LLEVLSSPTP
FIIGVHSIFK TDVHELLDVI IADLDGGTIK IPECIHLSSL PEPLLQQTQA ALSLILHPDL
EVADHAFPPP RTALSHSKML DKEVRAVFLR LFAQLFQGYR SCLQLIRIHA EPVIHFHKTA
FLGQRGLVEN DFLIKVLNGM AFAGFVSERG PPYRSCDLFD ELVAFEVERI KVEENNPLKM
IKHVRELAEQ LFKNENPNPH MAFQKVPRPT EGSHLRVHIL PFPKINETRV QELIQENLAK
NQNAPPALRV EKKWVVPAGP PVVSIMDKVT TVFNSAQRLE VVRNCISFIF ENKTLETEKT
LPAALRALKG KAARQCLTDE LGLHVQQNRA ILDHQQFDYI IRMMNCTLQD CSSLEEYNIA
AALLPLTSAF YRKLAPGVSQ FAYTCVQDHP IWTNQQFWET TFYNAVQEQV RSLYLSAKED
NHALHLKQKD KLPDDQYQEK TAMDLAAEQL RLWPTLSKST QQELVQREES TVFSQAIHFA
NLMVNLLVPL DTSKNKLLRA SAPGDWESGS NSIVTNSIAG SVAESYDTES GFEDSENNDI
ANSVVRFITR FIDKVCTESG VTQDHIKSLH CMIPGIVAMH IESLEAVHRE SRRLPPIQKP
KILRPALLPG EEVVCEGLRV LLDPDGREEA TGGLLGGPQL LPAEGALFLT TYRILFRGTP
HDQLVGEQTV VRSFPIASIT KEKKITMQNQ LQQNMQEGLQ ITSASFQLIK VAFDEEVSPE
VVEIFKKQLM KFRYPQSIFT TFAFAAGQTT PQIILPKQKE KNTSFRTFSK TIVKGAKRAG
KMTIGRQYLL KRRTGTIVEE RVNRPGWNEE DDVSVSDDSE LPTSTTLKAS EKSTMEQLVE
KACFRDYQRL GLGTISGSSS RSKPEYFRIT ASNRMYSLCR SYPGLLVVPQ AVQDSSLPRV
ARCYRHNRLP VVCWKNSRSS TLLLRAGGFH GKGVVGLFKS QNSPQAAPTS SLESSSSIEQ
EKYLQALLNA VSVHQKLSGN NTLTVRPALA LSPGVWASLR SSTRLISSPT SFIDVGARLA
GKDHSASFSN SAYLQNQLLK RQAALYIFGE KSQLRNFKLE FALNCEFVPV EFHDIRQVKA
SFKKLMRACV PSTIPTDSEV TFLKALGDSE WFPQLHRIMQ LAVVVSEILE NGSSVLVCLE
EGWDVTAQVT SLVQLLSDPF YRTLEGFRML IEKEWLSFGH KFSQRSSLTL NSQGSGFAPV
FLQFLDCVHQ VHTQYPTEFE FNLYYLKFLA FHYVSNRFKT FLLDSDYERL EHGTLFDDKG
DKHAKKGICI WECIDRMHKR SPIFFNYLYS PVEIEALKPS VNVSSLKKWD YYIEETLSTG
PSYDWMMLSP KHFSSEDSEL AGGAGPRSQR KTVWPCYDDV RCAQPDALTS LFSEIERLEH
KLNQTPEKWQ QLWERVTVDL KEEPRADRPQ RHPSGSPGIV STNLPSYQKR SLLHLPDSSV
GDEQNASVSP SNGVDRRAAT LYSQYTSKND ENRSFEGTLY KRGALLKGWK PRWFVLDVTK
HQLRYYDSGE DTSCKGHIDL AEVEMVIPAG PSMGAPKHTS DKAFFDLKTS KRVYNFCAQD
GQSAQQWMDR IQSCISDA
//
