ID F7CRL8_MONDO Unreviewed; 961 AA.
AC F7CRL8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=ADAMTS like 2 {ECO:0000313|Ensembl:ENSMODP00000016252.4};
GN Name=ADAMTSL2 {ECO:0000313|Ensembl:ENSMODP00000016252.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000016252.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000016252.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000016252.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7CRL8; -.
DR STRING; 13616.ENSMODP00000016252; -.
DR Ensembl; ENSMODT00000016552.4; ENSMODP00000016252.4; ENSMODG00000012996.4.
DR eggNOG; KOG3538; Eukaryota.
DR GeneTree; ENSGT00940000159447; -.
DR HOGENOM; CLU_000660_6_1_1; -.
DR InParanoid; F7CRL8; -.
DR OMA; CGEGHQF; -.
DR TreeFam; TF316874; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000012996; Expressed in placenta and 13 other cell types or tissues.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0050436; F:microfibril binding; IEA:Ensembl.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:Ensembl.
DR GO; GO:0060481; P:lobar bronchus epithelium development; IEA:Ensembl.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR045371; ADAMTS_CR_3.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723:SF41; A DISINTEGRIN AND METALLOPROTEINASE WITH THROMBOSPONDIN MOTIFS 8; 1.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR Pfam; PF19236; ADAMTS_CR_3; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 4.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR SMART; SM00209; TSP1; 7.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 922..960
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT REGION 533..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 533..556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 66..107
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 70..112
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 81..97
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ SEQUENCE 961 AA; 107198 MW; 12D771AFE689BD75 CRC64;
MDAGWRHSGW GFWTWSPLKS LLAVVLVTGN VMLVIAKGNV QTSNSLEEGA DATAYWWGEW
TKWTACTRTC GGGVKSQERH CLRQRRKSVP GLGNKTCTGT SKRHQLCKVQ ECPSDGRSFR
EEQCISFNSH VYNGRTYQWK PLYPDDYVHI SSKPCDLHCT TVDGQRQLMV PARDGTSCKF
IDFRGVCVSG KCEPIGCDGV LFSTHTLDKC GVCQGDGSSC THVTGNYRKG NAHLGYSLVT
HIPAGARDIQ IVERKKSADV LALADEAGYY FFNGNYKVDS PKNFNIAGTI VKYRRPMDVY
ETGIEYIVAQ GPTNQGLNVM VWNQNGKSPS ITFEYTLLRK PHPQSIQPVY YTFSETASES
AESREFDGEG LVGFVQHNST YYGKSSKERL DLENQLFGQQ GPSEDFNLSK GQETNEVYER
AGGMDCEAPL GGKTFRNTTQ MVHTGEKEDQ DTDVHFASQE FLSENAISDQ LLGKSSDSKE
FVLNVTVNSI FAQSDPHHPG GSPTDSLYLD YEENEGAYNL NGTYLELTSD RMANTSSETP
FPNASVTLPS SPGNRTHKAR TRPKSRKQGV SPADMYRWKL SSHEPCSSTC TTGVMSTYAM
CVRYDGIEVD DSYCDALTRP EPVHEFCAGR ECQPRWETSS WSECSRTCGE GYQFRIVRCW
KMISPGFDSS VYSDLCESAE ITRPDERKTC KNPACGPQWE MSEWSECAAR CGERSVVTRD
IRCSEDEKLC DINTRPVAEK NCTGPPCDRQ WTVSDWGPCS GSCGQGRMIR HVYCKTSDGR
VVPESQCNME AKPLAIHPCG DKNCPAHWLA QDWERCNTTC GRGVKKRIVL CLELANGKLK
TRSPPDCDIT KKPTEESTCF ERPCFKWYTT PWSECTKTCG VGVRMRDVKC YQGTDIVRGC
DPLVKPVAKQ TCDLQPCPTE PPDDSCQDQP GTNCALAIKV NLCSHWYYSK ACCRSCRPSH
S
//
