ID F7CT24_CALJA Unreviewed; 1097 AA.
AC F7CT24;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 4.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Structural maintenance of chromosomes 6 {ECO:0000313|Ensembl:ENSCJAP00000013618.5};
GN Name=SMC6 {ECO:0000313|Ensembl:ENSCJAP00000013618.5};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000013618.5, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000013618.5}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000013618.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC6 subfamily.
CC {ECO:0000256|ARBA:ARBA00006793}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7CT24; -.
DR Ensembl; ENSCJAT00000014343.5; ENSCJAP00000013618.5; ENSCJAG00000007282.5.
DR GeneTree; ENSGT00550000074816; -.
DR OMA; MCHDHFY; -.
DR Proteomes; UP000008225; Chromosome 14.
DR Bgee; ENSCJAG00000007282; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0000775; C:chromosome, centromeric region; IEA:Ensembl.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0035061; C:interchromatin granule; IEA:Ensembl.
DR GO; GO:0097431; C:mitotic spindle pole; IEA:Ensembl.
DR GO; GO:0016605; C:PML body; IEA:Ensembl.
DR GO; GO:0000803; C:sex chromosome; IEA:Ensembl.
DR GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR GO; GO:0030915; C:Smc5-Smc6 complex; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000217; F:DNA secondary structure binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0090398; P:cellular senescence; IEA:Ensembl.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0044828; P:negative regulation by host of viral genome replication; IEA:Ensembl.
DR GO; GO:0051984; P:positive regulation of chromosome segregation; IEA:Ensembl.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:Ensembl.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR PANTHER; PTHR19306; STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6; 1.
DR PANTHER; PTHR19306:SF6; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Telomere {ECO:0000256|ARBA:ARBA00022895}.
FT DOMAIN 56..263
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 812..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 236..263
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 289..457
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1097 AA; 126849 MW; 6329952A1A4AF75D CRC64;
MAKRKEENFS PPKNVKRPRQ EELEDLEKDG DEDECTASFT NGTSTLTAAE VGIIESIRLK
NFMCHSMLGP FKFGSNVNFV VGNNGSGKSA VLTALIVGLG GRAVATNRGS SLKGFVKDGQ
NSADISITLR NRGDDAFKAS VYGNSIIVQQ HISMDGSRSY KLKSEAGSVV STKKEELIAI
LDHFNIQVDN PVSVLTQEMS KQFLQSKNEG DKYKFFMKAT QLEQMKEDYS YIMETKERTK
EQISQGEERL TELKRQCLEK EERFQNIAGL STMKATLENL KHEMAWAVVN EIEKQLNAIR
DNIKIGEDRA ARLDRKMEEQ QVRLNEAEQK YKDIQDKLEK ISEETNARAP ECMALKADAV
AKKRAYNEAE VLYNRSLNEY KALKKDDEQL CKRIEELKKS TDQSLEPERL ERQKKISWLK
ERVKALQNQE NSVSQEIEQF QQAIEKDREE HGKIKREELD LKHTLSYNHK QLKELKDSKT
DRLKRFGPNV PALLEAIDDA YRQGRFTCKP VGPLGACIHL RDPELALAIE SCLKGLLQAY
CCHNHADERV LQALMKKFYL PGTSRPQIIV SEFRNEIYDV RHRAAYHPEF PTVLTALEID
NAVVANSLID MRGIETVLLI KNNSVARAVM QSQKPPKNCR EAFTADGDQV FPGRYYSSEY
TRPKFLSKDV DSEISDLEHE VENKTAQILN LQQHLSALEK DIKRNEELLK RCQLHYKELK
MKIRKNISEI RELENIEEHQ SVDIATLEDE AQENKSKMKM VEKHMEQQKE SMEHLRSLKI
EAENKYDAIK LKINQLSELA DPLKDELNLA DSEVDNQKRG KRHYEEKQKE HLDTLNKKKR
ELDMKEKELE EKMSQARQIC PERIEVEKSA STLDKEINRL RQQIQAEHAS HGDREEIMRQ
YQEARETYLD LDNKVRTLKK FIKLLGEIMT HRFKTYQQFR RCLTLRCKLY FDNLLSQRAY
CGKMNFDHKN ETLSISVQPG EGNKAAFNDM RALSGGERSF STVCFILSLW SIAESPFRCL
DEFDVYMDMV NRRIAMDLIL KMADSQRFRQ FILLTPQSMS SLPSSKLIRI LRMSDPERGQ
TTLPFRPVTQ EEEDDQS
//
