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Database: UniProt
Entry: F7CU75_ORNAN
LinkDB: F7CU75_ORNAN
Original site: F7CU75_ORNAN 
ID   F7CU75_ORNAN            Unreviewed;      1675 AA.
AC   F7CU75;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   30-AUG-2017, entry version 50.
DE   SubName: Full=Sodium leak channel, non-selective {ECO:0000313|Ensembl:ENSOANP00000017913};
GN   Name=NALCN {ECO:0000313|Ensembl:ENSOANP00000017913};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000017913, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000017913}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017913};
RX   PubMed=8919867; DOI=10.1007/BF02198841;
RA   Janke A., Gemmell N.J., Feldmaier-Fuchs G., von Haeseler A., Paabo S.;
RT   "The mitochondrial genome of a monotreme--the platypus
RT   (Ornithorhynchus anatinus).";
RL   J. Mol. Evol. 42:153-159(1996).
RN   [2] {ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E.,
RA   Ponting C.P., Grutzner F., Belov K., Miller W., Clarke L.,
RA   Chinwalla A.T., Yang S.P., Heger A., Locke D.P., Miethke P.,
RA   Waters P.D., Veyrunes F., Fulton L., Fulton B., Graves T., Wallis J.,
RA   Puente X.S., Lopez-Otin C., Ordonez G.R., Eichler E.E., Chen L.,
RA   Cheng Z., Deakin J.E., Alsop A., Thompson K., Kirby P.,
RA   Papenfuss A.T., Wakefield M.J., Olender T., Lancet D., Huttley G.A.,
RA   Smit A.F., Pask A., Temple-Smith P., Batzer M.A., Walker J.A.,
RA   Konkel M.K., Harris R.S., Whittington C.M., Wong E.S., Gemmell N.J.,
RA   Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J., Zemann A.,
RA   Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H.,
RA   Taylor J., Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y.,
RA   Huang X., Stark A., Kheradpour P., Kellis M., Flicek P., Chen Y.,
RA   Webber C., Hardison R., Nelson J., Hallsworth-Pepin K., Delehaunty K.,
RA   Markovic C., Minx P., Feng Y., Kremitzki C., Mitreva M., Glasscock J.,
RA   Wylie T., Wohldmann P., Thiru P., Nhan M.N., Pohl C.S., Smith S.M.,
RA   Hou S., Nefedov M., de Jong P.J., Renfree M.B., Mardis E.R.,
RA   Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of
RT   evolution.";
RL   Nature 453:175-183(2008).
RN   [3] {ECO:0000313|Ensembl:ENSOANP00000017913}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000017913};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOANP00000017913}.
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DR   STRING; 9258.ENSOANP00000017913; -.
DR   Ensembl; ENSOANT00000017916; ENSOANP00000017913; ENSOANG00000011307.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; F7CU75; -.
DR   OrthoDB; EOG091G00F9; -.
DR   TreeFam; TF312843; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000011307; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005261; F:cation channel activity; IBA:GO_Central.
DR   GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
DR   GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028823; NALCN.
DR   PANTHER; PTHR10037:SF252; PTHR10037:SF252; 1.
DR   Pfam; PF00520; Ion_trans; 4.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002279};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     41     61       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     67     88       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    108    127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    139    158       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    178    195       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    299    322       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    385    406       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    418    446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    506    528       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    575    599       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    881    905       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    956    974       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1017   1040       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1134   1157       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1211   1231       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1237   1256       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1276   1294       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1336   1358       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1423   1447       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       36    331       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      384    603       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      887   1162       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1209   1457       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      798    827       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1675 AA;  193731 MW;  2FD8B13188300E5E CRC64;
     MLKRKQSSRV EAQPVTDFGP DESLSDNADI LWINKPWVHS LLRICAIISV ISVCMNTPMT
     FEHYPPLQYV TFALDTLLMF LYTAEMIAKM HIRGIVKGDN SYVKDRWCVF DGFMVFCLWV
     SLVLQVFEIA DIVDQMSPWG MLRIPRPLIM IRAFRIYFRF ELPRTRITNI LKRSGEQIWS
     VSIFLLFFLL LYGILGVQMF GTFTYHCVTD DTQPGNVTWN NLAIPDTHCS RELEEGYQCP
     PGFKCMDLED LGLSRQELGY SGFNEIGTSI FTVYEAASQE GWVFLMYRAI DSFPRWRSYF
     YFITLIFFLA WLVKNVFIAV IIETFAEIRV QFQQMWGSRS STTSTATTQM FHEDAAGGWQ
     LVAVDVNKPQ GRAPACLQKM MRSSIFHMFI LSMVAVDVIV AASNYYKGEN FRRQYDEFYL
     AEVAFTVLFD LEALLKIWCL GFTGYISSSL HKFELLLVMG TTLHIYPDLY HSQFTYFQVL
     RVVRLIKISP ALEDFVYKIF GPGKKLGSLV VFTASLLIVM SAISLQMFCF VEELDRFTTF
     PRAFMSMFQI LTQEGWVDVM DQTLNAVGHM WAPVVAIYFI LYHLFATLIL LSLFVAVILD
     NLELDEDLKK LKQLKQSEAN ADTKEKLPLR LRIFEKFPNR PQMVKISKLP SDFTVPKIRE
     SFMKQFIDRQ QQDTSCLLRR LPSASSSSCD HSKRSAIEDN KYIDQKLRKS VFSIRARNLL
     EKETAITKIL RACTRQRMLS GSFEGQPAKE RSILSVQHHI RQERRSLRHG SNSQRISRGK
     SLETLTQDHS NTVRYRNAQR EDSEIKMIQE KKEQAEMKRK VQEEELRENH PYFDKPLFIV
     GREHRFRNFC RVVVRARFNA SKTDPVTGAV KNTKYHQLYD LLGLVTYLDW VMIIVTICSC
     ISMMFESPFR RVMHAPTLQI AEYVFVIFMS IELNLKIMAD GLFFTPTAVI RDFGGVMDIF
     IYLVSLIFLC WMPQNVPAKS GAQLLMVLRC LRPLRIFKLV PQMRKVVREL FSGFKEIFLV
     SILLLTLMLV FASFGVQLFA GKLAKCNDPQ IMRREDCHGI FRINVSVSKN LNLKLRPGEK
     KPGFWVPRVW ANPRNFNFDN VGNAMLALFE VLSLKGWVEV RDVIIHRVGP IHGIYIHVFV
     FLGCMIGLTL FVGVVIANFN ENKGTALLTV DQRRWEDLKS RLKIAQPLHL PPRPDNDGFR
     AKMYDITQHP FFKRTIAVLV LAQSVLLSVK WDVEDPVTVP LATMSVVFTF IFVLEVTMKI
     IAMSPAGFWQ SRRNRYDLLV TSLGVIWVIL HFALLNAYTY MMGACVIVFR FFSICGKHVT
     LKMLLLTVVV SMYKSFFIIV GMFLLLLCYA FAGVVLFGTV KYGENINRHA NFSSAGKAIT
     VLFRIVTGED WNKIMHDCMV QPPFCTPDEF KYWATDCGNY AGALMYFCSF YVIIAYIMLN
     LLVAIIVENF SLFYSTEEDQ LLSYSDLRHF QIIWNMVDDK REGVIPTFRV KFLLRLLRGR
     LEVDLDKDKL LFKHMCYEME RLHNGGDVTF HDVLSMLSYR SVDIRKSLQL EELLAREQLE
     YTIEEEVAKQ TIRMWLKKCL KRIRAKQQQS CSIIHSLRES QQQELSRFLN PPSIETTQPS
     EDMNANNQDN NTQPETSSQQ QLLSPTLSDR GGCRQDSTDA GKPQRKFGQW RLPSA
//
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