ID F7CUS0_HORSE Unreviewed; 607 AA.
AC F7CUS0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Galactosidase beta 1 like {ECO:0000313|Ensembl:ENSECAP00000003944.3};
GN Name=GLB1L {ECO:0000313|VGNC:VGNC:18368};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000003944.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000003944.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003944.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000003944.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000003944.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 35 family.
CC {ECO:0000256|ARBA:ARBA00009809, ECO:0000256|RuleBase:RU003679}.
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DR AlphaFoldDB; F7CUS0; -.
DR STRING; 9796.ENSECAP00000003944; -.
DR PaxDb; 9796-ENSECAP00000003944; -.
DR Ensembl; ENSECAT00000005591.4; ENSECAP00000003944.3; ENSECAG00000003253.4.
DR VGNC; VGNC:18368; GLB1L.
DR GeneTree; ENSGT00950000182942; -.
DR HOGENOM; CLU_007853_7_2_1; -.
DR InParanoid; F7CUS0; -.
DR OMA; HERQYLH; -.
DR TreeFam; TF314816; -.
DR Proteomes; UP000002281; Chromosome 6.
DR Bgee; ENSECAG00000003253; Expressed in retina and 23 other cell types or tissues.
DR GO; GO:0005773; C:vacuole; IBA:GO_Central.
DR GO; GO:0004565; F:beta-galactosidase activity; IBA:GO_Central.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 4.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR026283; B-gal_1-like.
DR InterPro; IPR048912; BetaGal1-like_ABD1.
DR InterPro; IPR048913; BetaGal_gal-bd.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR031330; Gly_Hdrlase_35_cat.
DR InterPro; IPR001944; Glycoside_Hdrlase_35.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR23421; BETA-GALACTOSIDASE RELATED; 1.
DR PANTHER; PTHR23421:SF50; BETA-GALACTOSIDASE-1-LIKE PROTEIN; 1.
DR Pfam; PF21317; BetaGal_ABD_1; 1.
DR Pfam; PF21467; BetaGal_gal-bd; 1.
DR Pfam; PF01301; Glyco_hydro_35; 1.
DR PIRSF; PIRSF006336; B-gal; 2.
DR PRINTS; PR00742; GLHYDRLASE35.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..607
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040337164"
FT DOMAIN 38..353
FT /note="Glycoside hydrolase 35 catalytic"
FT /evidence="ECO:0000259|Pfam:PF01301"
FT DOMAIN 400..446
FT /note="Beta-galactosidase 1-like first all-beta"
FT /evidence="ECO:0000259|Pfam:PF21317"
FT DOMAIN 493..550
FT /note="Beta-galactosidase galactose-binding"
FT /evidence="ECO:0000259|Pfam:PF21467"
FT ACT_SITE 185
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
FT ACT_SITE 263
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006336-1"
SQ SEQUENCE 607 AA; 68963 MW; 816B3E29F20CF9CF CRC64;
MAPKKPPCLP SLLLPLLTLL LPQADTRSFV VDRDNDRFLL DGVPFRYVSG SLHYFRVPRV
LWADRLFKMR MSGLNAVQFY VPWNYHEPEP GVYNFHGSRD LIAFLNEAAI ANLLVILRPG
PYICAEWDMG GLPAWLLRKP KIHLRTSDPD FLAAVDSWFK VLLPKIHPWL YHNGGNIISI
QVENEYGSYR ACDFNYMRHL AGLFRAILGD EILLFTTDGP EGLKCGSLEG LYTTVDFGPA
DNMTKIFTLL RKYEPHGPLV NSEYYTGWLD YWGQNHSTRS VHSVTNGLEN MLKLGASVNM
YMFHGGTNFG YWNGADEKGR FLPITTSYDY DAPISEAGDP TPKLFALRDV ISKFQEIPLG
PLPPPSPKMM LGPLTLHLDG DLLAFLNYLC PQGPIYSILP MTFEAVKQDH GFVLYRTYLS
NTVSEPTRFW VPNNGVHDRA YVMVDGGLIE PPVLGQTILT RWLMFPLKVD KLVKWWFPLQ
LLKRSHPQTP SGPTFYSTMF AILGSSGDTF LYLPGWTKGQ VWINGFNLGR YWTKRGPQQT
LYVPRPLLYP RGALNKITLL ELENAPPQPQ VQFLDRPILN STLHRTYVYS LSAEVQSDPE
PMQLSGH
//
