ID F7CW27_MONDO Unreviewed; 1183 AA.
AC F7CW27;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=CTR9 homolog, Paf1/RNA polymerase II complex component {ECO:0000313|Ensembl:ENSMODP00000026715.5};
GN Name=CTR9 {ECO:0000313|Ensembl:ENSMODP00000026715.5};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000026715.5, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000026715.5, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000026715.5}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7CW27; -.
DR STRING; 13616.ENSMODP00000026715; -.
DR Ensembl; ENSMODT00000027194.5; ENSMODP00000026715.5; ENSMODG00000008303.5.
DR eggNOG; KOG2002; Eukaryota.
DR GeneTree; ENSGT00390000005097; -.
DR HOGENOM; CLU_006386_0_0_1; -.
DR InParanoid; F7CW27; -.
DR OMA; EHWLTIA; -.
DR TreeFam; TF314342; -.
DR Proteomes; UP000002280; Chromosome 5.
DR Bgee; ENSMODG00000008303; Expressed in forelimb bud and 21 other cell types or tissues.
DR GO; GO:0016593; C:Cdc73/Paf1 complex; IBA:GO_Central.
DR GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR GO; GO:0000993; F:RNA polymerase II complex binding; IBA:GO_Central.
DR GO; GO:0042169; F:SH2 domain binding; IEA:Ensembl.
DR GO; GO:0001832; P:blastocyst growth; IEA:Ensembl.
DR GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0001711; P:endodermal cell fate commitment; IEA:Ensembl.
DR GO; GO:0001826; P:inner cell mass cell differentiation; IEA:Ensembl.
DR GO; GO:0070102; P:interleukin-6-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IEA:Ensembl.
DR GO; GO:0045638; P:negative regulation of myeloid cell differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0007259; P:receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR GO; GO:0019827; P:stem cell population maintenance; IEA:Ensembl.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001829; P:trophectodermal cell differentiation; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR InterPro; IPR031101; Ctr9.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR14027; RNA POLYMERASE-ASSOCIATED PROTEIN CTR9; 1.
DR PANTHER; PTHR14027:SF2; RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG; 1.
DR Pfam; PF13374; TPR_10; 1.
DR Pfam; PF14559; TPR_19; 2.
DR Pfam; PF13181; TPR_8; 2.
DR SMART; SM00028; TPR; 10.
DR SUPFAM; SSF81901; HCP-like; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS50005; TPR; 4.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339}.
FT REPEAT 213..246
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 356..389
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 512..545
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 546..579
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REGION 907..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 843..900
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 910..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..973
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..999
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1007..1021
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1072
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1073..1092
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1093..1115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1116..1138
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1155..1169
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1183 AA; 134521 MW; 533EDBECC137AC8F CRC64;
MIVFSATETL VDLQNHRGGL QSSPTLMKSQ VIELDFDQLP EGDEVISILK QEHTQLHIWI
ALALEYYKQG KTEDFVKLLE AARIDGNLDY RDHEKDQMTC LDTLAAYYVQ QARKEKNKDN
KKELITQATL LYTMADKIIM YDQNHLLGRA CFCLLEGDKM DQADAQFHFV LNQSPNNIPA
LLGKACISFN KKDYRGALAY YKKALRTNPG CPAEVRLGMG HCFVKLNKLE KARLAFSRAL
ELNSKCVGAL VGLAVLELNN KEADSIKNGV QLLSRAYTID PSNPMVLNHL ANHFFFKKDY
SKVQHLALHA FHNTEVEAMQ AESCYQLARS FHVQEDYDQA FQYYYQATQF ASSSFVLPFF
GLGQMYIYRG DKENASQCFE KVLKAYPNNY ETMKILGSLY AASEDQDKRD IAKGHLKKVT
EQYPDDVEAW IELAQILEQT DIQGALSAYG TATRILQEKV QADVPPEILN NVGALHFRLG
NLGEAKKYFL ASLDRAKAEA EHDEHYYNAI SVTTSYNLAR LYEAMCEFHE AEKLYKNILR
EHPNYVDCYL RLGAMARDKG NFYEASDWFK EALQINQDHP DAWSLIGNLH LAKQEWGPGQ
KKFERILKQP STQNDTYSML ALGNVWLQTL HQPTRDREKE KRHQDRALAI YKQVLRNDPK
NLYAANGIGA VLAHKGYFRE ARDVFAQVRE ATADISDVWL NLAHIYVEQK QYISAVQMYE
NCLRKFYKHQ NTEVVLYLAR ALFKCGKLQE CKQTLLKARH VAPSDTVLMF NVALVLQRLA
TSVLKDEKSN LKEVLNAVKE LELAHRYFSY LSKVGDKMRF DLALAATEAR QCSDLLSQAQ
YHVARARKQD EEERELRAKQ EQEKELLRQK LLKEQEEKRL REKEEQKKLL EQRAQYVEKT
KNILMFTGEA EGTKEKKRGG GGGGGRRSKK GGEFDEFVND DTDEDMPVSK KKKKRKGSGS
EQEGEEEEGE RKKKKRRRPP KGDDGSDEEE TENGPRPKKR RTPRVEKKKA PKPERLPPSM
KGKIKSKAII SSSDDSSDED KLKIADEGHA RNSNSDSDDG DLRKKRVMSE SDSDENPNQS
GSEAGSPRRS SMQQSEEDSD SDRSAPKRRR SVSEQSDNES VQSGRSHSAG SDNESRPASP
SADSDRESER ASDNEASARG SGNDSEPEAS NNEASERGSD DSD
//
