ID F7CYC8_HORSE Unreviewed; 649 AA.
AC F7CYC8;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Armadillo repeat-containing protein 8 {ECO:0000256|ARBA:ARBA00013746};
GN Name=ARMC8 {ECO:0000313|Ensembl:ENSECAP00000012346.3,
GN ECO:0000313|VGNC:VGNC:15533};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012346.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000012346.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012346.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000012346.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012346.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR AlphaFoldDB; F7CYC8; -.
DR STRING; 9796.ENSECAP00000012346; -.
DR PaxDb; 9796-ENSECAP00000012346; -.
DR Ensembl; ENSECAT00000015368.3; ENSECAP00000012346.3; ENSECAG00000014265.4.
DR CTD; 25852; -.
DR VGNC; VGNC:15533; ARMC8.
DR GeneTree; ENSGT00390000003033; -.
DR HOGENOM; CLU_002741_3_0_1; -.
DR InParanoid; F7CYC8; -.
DR OMA; KGTDQHV; -.
DR OrthoDB; 5385808at2759; -.
DR TreeFam; TF324806; -.
DR Proteomes; UP000002281; Chromosome 16.
DR Bgee; ENSECAG00000014265; Expressed in bone marrow and 23 other cell types or tissues.
DR GO; GO:0034657; C:GID complex; IBA:GO_Central.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR038739; ARMC8/Vid28.
DR PANTHER; PTHR15651; ARMADILLO REPEAT-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR15651:SF7; ARMADILLO REPEAT-CONTAINING PROTEIN 8; 1.
DR Pfam; PF00514; Arm; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT REPEAT 61..97
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 649 AA; 72865 MW; F3464B4F665CF81D CRC64;
MACLLETPIR MSVLSEVTAS SRHYVDRLFD PDPQKVLQGV IDMKNAVIGN NKQKANLIVL
GAVPRLLYLL QQETSSTELK TECAVVLGSL AMGTENNVKS LLDCHIIPAL LQGLLSPDLK
FIEACLRCLR TIFTSPVTPE ELLYTDATVI PHLMALLSRS RYTQEYICQI FSHCCKGPDH
QTILFNHGAV QNIAHLLTSV SYKVRMQALK CFSVLAFENP QVSMTLVNVL VDGELLPQIF
VKMLQRDKPI EMQLTSAKCL TYMCRAGAIR TDDNCIVLKT LPCLVRMCSK ERLLEERVEG
AETLAYLIEP DVELQRIASI TDHLIAMLAD YFKYPSSVSA ITDIKRLDHD LKHAHELRQA
AFKLYASLGA NDEDIRKKII ETENMMDRIV TGLSESSVKV RLAAVRCLHS LSRSVQQLRT
SFQDHAVWKP LMKVLQNAPD EILVVASSML CNLLLEFSPS KEPILESGAV ELLCGLTQSE
NPALRVNGIW ALMNMAFQAE QKIKADILRS LSTEQLFRLL SDSDLNVLMK TLGLLRNLLS
TRPHIDKIMS THGKQIMQAV TLILEGEHNI EVKEQTLCIL ANIADGTTAK ELIMTNDDIL
QKIKYYMGHS HVKLQLAAMF CISNLVWNEE EGKRLAHKNA RINYETWAS
//
