ID F7D1Q3_MONDO Unreviewed; 1882 AA.
AC F7D1Q3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=von Willebrand factor A domain containing 8 {ECO:0000313|Ensembl:ENSMODP00000018544.4};
GN Name=VWA8 {ECO:0000313|Ensembl:ENSMODP00000018544.4};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000018544.4, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000018544.4, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000018544.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 13616.ENSMODP00000018544; -.
DR Ensembl; ENSMODT00000018877.4; ENSMODP00000018544.4; ENSMODG00000014823.4.
DR eggNOG; KOG1808; Eukaryota.
DR GeneTree; ENSGT00390000006601; -.
DR HOGENOM; CLU_001400_0_0_1; -.
DR InParanoid; F7D1Q3; -.
DR OMA; GTHIVHP; -.
DR TreeFam; TF300317; -.
DR Proteomes; UP000002280; Chromosome 7.
DR Bgee; ENSMODG00000014823; Expressed in skeletal muscle tissue and 20 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:Ensembl.
DR CDD; cd00009; AAA; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039891; VWA8.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR21610; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8; 1.
DR PANTHER; PTHR21610:SF9; VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 8; 1.
DR Pfam; PF07728; AAA_5; 3.
DR SMART; SM00382; AAA; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 1692..1873
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1515..1564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1515..1540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1882 AA; 211817 MW; DE208C93F2B179A8 CRC64;
MQSRLLLLST SGATGGSGSG GGSSAARRVR LILRQVVRGR PGAEGLRLRH TGAGVDAGNT
IHIGDVSYKL KTPKNPEFVP KNYISDSLAQ TVVQHLRWIM QKDLLGQDVF LIGPPGPLRR
SIAMQYLELT KREVEYIALS RDTTETDLKQ RREIRAGTAF YIDQCAVRAA TEGRTLVLEG
LEKAERNVLP VLNNLLENRE MQLEDGRFLM SAERYDKLLQ DHTKTELDTW KIVRVSEDFR
VIALGLPVPR YTGNPLDPPL RSRFQARDIY YLPFKDQLKL LYSIGSNISA ERVSQVLSFA
TTLCSQESST LGLPDFPLDS LPHAIQILDF FPAMSIQNLI QWLYPYTILL GHDGKMAVED
VLKVRTWYDI IEIHGSIPLI SFSGTRPLNQ HSESNHFIKT LSHKQLLAEM VQSHMVKDMC
LIGGKGCGKT VIAKEFADAL GYAIEPIMLY QDMTARDLLQ QRYTLPNGDT AWRSSPLITA
ALEGKLVLLD GIHRVNAGTL AVLQRLIHDR ELSLYDGSRL LREDRYKHLK EELQLSDEQL
KKRSIYPIHP SFRIIALAEP PVIGSSSQQW LGPEFLTMFF FHHMKPLARS EEIQVIKEMV
SNVPQDAVEK LLSFTHKLRE TQDPTAQSLA ASLSTRQLLR IARRLSKYPD ESLHKAVHKA
CLSRFLPSLA RSALEKNLLD ARIEATTDNH LEPEPKDYRC EIKSGSLKIG NISIPVHNTN
EKMKVPDVLF YENFQHMILM EDMLKDFLLG EHLLLVGNQG VGKNKIVDRF LHLLNRPREY
IQLHRDTTVQ TLTLQPSVKD GLIVYEDSPL VKAVKMGYIL VVDEADKAPT NVTCILKTLV
ENGEMILADG RRIVADAANV NGRENIIVIH PDFRMIVLAN RPGFPFLGND FFGTLGDIFS
CHAVDNPKPQ SELEMLRQYG PNVPEPILQK LVAAFGELRH LADQGIINYP YSTREVVNIV
KHLQKFPNEG LANVVRNVFD FDSYNNDMRE TLMNILHKYG IPIGAKPTSV QLAKELPLPE
QSFMGYWTIS PPKNGMQKFL SPAETQHIDL KGPLHLSFQE YPLERREGRT LTFTEECASW
KLPIDEVNIV CDVAVAQENE ESILYVVTCN PVALYFMNMS GKKGHFVDFY DLFPRTSSGV
WHPFVTVAPL GNPLKGLVIL HEEQSNAILL LDTRDQTLRR LVLPSEDEFG AMKTGWWSRE
ESVRTYKMCK EFSHKNWLVF YREKGNSLIV LDVLEGQTHT IFLPISLKSV FLVAEDRWLL
IENNTNQKFL LAKPGHVESK EKGVCQLHIL KEEPVSTGFG FTKESELNIP HKVSSNQLSS
ENLSLAVGQK IASPNRILSD ENNYATVLVG FPDLMSPSEV YSWKRQSSLG AEIVSTSMLY
KGKSKSGTPK QNNCVILLDS NQVVRILPPG DVPLKEIFPK DVTPPQTSGY IEVTDLQSKK
LRYIPIPGSD FLSPYTTWLS TISDTDALLA EWGKGGVVTV DMGGTVRLWE TGLEHLQRSL
LEWKNMIGQE EKAAQITIDR DSYEDVSSPK HGKEDPENEP HVGGNTWAGG TGGRDTAGLG
GKGGPYRLDA GHNVYQISQA EKDAVPEEVK RAAREMGQKA FQQRLKEIKM SEYDATSYER
FSGAVRRQVH ALRIILDNLQ AKGKERQWLR HQPTGELDDA KIIDGLTGEK AIYKRRGEMK
PELGNPQEKP KRLRLLVDVS GSMYRFNGVD GRLERSMEAV CMVMEAFENY EEKFKYDIAG
HSGDGYVKLV PLDKIPKDNK QRLQILKTMY AHAQFCMSGD STLEATEHAI NEIAKEDADE
YFVIVLSDAN LERYGIPPMR LAQILTANPQ VNAFAIFIGS LGDQAARLQK TLPAGRSFVA
MDTKKIPQIL QQIFTSTMLS SI
//
