ID F7D271_HORSE Unreviewed; 617 AA.
AC F7D271;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Autophagy related 16 like 2 {ECO:0000313|Ensembl:ENSECAP00000012633.2};
GN Name=ATG16L2 {ECO:0000313|Ensembl:ENSECAP00000012633.2,
GN ECO:0000313|VGNC:VGNC:58560};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012633.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000012633.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012633.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000012633.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012633.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat ATG16 family.
CC {ECO:0000256|ARBA:ARBA00009271}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7D271; -.
DR SMR; F7D271; -.
DR STRING; 9796.ENSECAP00000012633; -.
DR PaxDb; 9796-ENSECAP00000012633; -.
DR Ensembl; ENSECAT00000015692.3; ENSECAP00000012633.2; ENSECAG00000013038.3.
DR VGNC; VGNC:58560; ATG16L2.
DR GeneTree; ENSGT00940000153936; -.
DR HOGENOM; CLU_2037261_0_0_1; -.
DR InParanoid; F7D271; -.
DR OMA; PHCAAIN; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000013038; Expressed in leukocyte and 23 other cell types or tissues.
DR GO; GO:0000421; C:autophagosome membrane; IBA:GO_Central.
DR GO; GO:0000045; P:autophagosome assembly; IBA:GO_Central.
DR GO; GO:0039689; P:negative stranded viral RNA replication; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045160; ATG16.
DR InterPro; IPR013923; Autophagy-rel_prot_16_dom.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR19878; AUTOPHAGY PROTEIN 16-LIKE; 1.
DR PANTHER; PTHR19878:SF7; PROTEIN ATG16L2; 1.
DR Pfam; PF08614; ATG16; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 17..205
FT /note="Autophagy-related protein 16"
FT /evidence="ECO:0000259|Pfam:PF08614"
FT REPEAT 330..363
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 374..415
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 416..457
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 554..583
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 60..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 617 AA; 68422 MW; BDA52DEE2E96230E CRC64;
MAGRGAPAGL AARWKRHIVR QLRQRDRTQK ALFLELVPAY NRLLEKAELL ARFSEKIQPE
PNDVTPASHQ GLWEESGPDS DQVPGTLRVK WREEEEGLRL VCGEMAYQVV EKSAALGALE
AELEQRQSRL AELEARVAQL QEERTQQAQR VHVRRARNAA QRAAYEALRA HAGVQEAALR
RLEEEARELL ERLVQHKARA AAERNLRNER RERAKQARVS QELKKAAKRP VSISESPSIL
GYAVREPAKT LALAAEPESL ESEAAEKLRR PFRSASATSL TLSRCVDVVK GLLDFKKRRG
HSVGGAPEQR YQSIPVCVAA RLPTWTQDVV DAHLSEVNAV CFGPNSSLLA TGGADSLIHL
WNVVGGHLKA HQTLEGGGGS ITSVDFDPSG SQVLAATYNR AAQLWKVGEA QSKETLSGHT
DKVTAAKFKL TRHEAVTGSR DRTVKEWDLG RAYCSRTINV LSYCNDVVCG DHLIISGHND
QKIRFWDSRG PRCTQVIPVQ GRVTSLSLSH DQLHLLSCSR DDTLKVIDLR VSNIRQVFRA
EGFKCGSDWT KAVFSPDRCY ALAGSWDGAL YIWDVDTGKL ESSLRGPHCA AVNAVAWCYS
GTHVVSVDQA RKVVLWH
//
