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Database: UniProt
Entry: F7D3Y9_HORSE
LinkDB: F7D3Y9_HORSE
Original site: F7D3Y9_HORSE 
ID   F7D3Y9_HORSE            Unreviewed;       823 AA.
AC   F7D3Y9;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   28-MAR-2018, entry version 44.
DE   RecName: Full=Phosphodiesterase {ECO:0000256|RuleBase:RU363067};
DE            EC=3.1.4.- {ECO:0000256|RuleBase:RU363067};
GN   Name=PDE5A {ECO:0000313|Ensembl:ENSECAP00000012300,
GN   ECO:0000313|VGNC:VGNC:21247};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012300, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000012300, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012300,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000012300}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012300};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000256|RuleBase:RU363067};
CC       Note=Binds 2 divalent metal cations per subunit. Site 1 may
CC       preferentially bind zinc ions, while site 2 has a preference for
CC       magnesium and/or manganese ions. {ECO:0000256|RuleBase:RU363067};
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase
CC       family. {ECO:0000256|RuleBase:RU363067,
CC       ECO:0000256|SAAS:SAAS00865541}.
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DR   RefSeq; XP_005607927.1; XM_005607870.2.
DR   ProteinModelPortal; F7D3Y9; -.
DR   Ensembl; ENSECAT00000015316; ENSECAP00000012300; ENSECAG00000013957.
DR   GeneID; 100072395; -.
DR   CTD; 8654; -.
DR   VGNC; VGNC:21247; PDE5A.
DR   eggNOG; KOG3689; Eukaryota.
DR   eggNOG; ENOG410XRI7; LUCA.
DR   GeneTree; ENSGT00760000119066; -.
DR   Proteomes; UP000002281; Chromosome 2.
DR   Bgee; ENSECAG00000013957; -.
DR   ExpressionAtlas; F7D3Y9; baseline.
DR   GO; GO:0004114; F:3',5'-cyclic-nucleotide phosphodiesterase activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd00077; HDc; 1.
DR   Gene3D; 1.10.1300.10; -; 1.
DR   Gene3D; 3.30.450.40; -; 3.
DR   InterPro; IPR003018; GAF.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR003607; HD/PDEase_dom.
DR   InterPro; IPR023088; PDEase.
DR   InterPro; IPR002073; PDEase_catalytic_dom.
DR   InterPro; IPR036971; PDEase_catalytic_dom_sf.
DR   InterPro; IPR023174; PDEase_CS.
DR   Pfam; PF01590; GAF; 2.
DR   Pfam; PF00233; PDEase_I; 1.
DR   PRINTS; PR00387; PDIESTERASE1.
DR   SMART; SM00065; GAF; 2.
DR   SMART; SM00471; HDc; 1.
DR   PROSITE; PS00126; PDEASE_I; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Hydrolase {ECO:0000256|RuleBase:RU363067,
KW   ECO:0000256|SAAS:SAAS00865573};
KW   Metal-binding {ECO:0000256|RuleBase:RU363067,
KW   ECO:0000256|SAAS:SAAS00865543};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT   DOMAIN      112    272       GAF. {ECO:0000259|SMART:SM00065}.
FT   DOMAIN      294    461       GAF. {ECO:0000259|SMART:SM00065}.
FT   DOMAIN      558    726       HD. {ECO:0000259|SMART:SM00471}.
SQ   SEQUENCE   823 AA;  93527 MW;  0D6195A11B9A0AE1 CRC64;
     MVNAWFADRV HTIPVCKEGI RGHPESCSCS LQQTPRADSS APGTPTRKIS ASEFDRPLRP
     IVVKDSEGTV SFLSDSEKKE QMPLTPPKFD NDEGDQCSRL LELVKDISSH LDVTALCHKI
     FLHIHGLIAA DRYSLFLVCE DSSNDKFLIS RLFDVAEGST LEEASNNCIR LEWNKGIVGH
     VAALGEPLNI KDAYEDPRFN AEVDQITGYK TQSILCMPIK NHREEVVGVA QAINKKSGNG
     GTFTEKDEKD FAAYLAFCGI VLHNAQLYET SLLENKRNQV LLDLASLIFE EQQSLEVILK
     KIAATIISFM QVQKCTIFIV DEDCSDSFSS VFHMECEELE KSSDTLTRER DANRINYMYA
     QYVTNTMEAL NIPDVSKDKR FPWTNENTGN VNQQCIRSLL CTPIKNGKKN KVIGVCQLVN
     KMEENTGKVK PFNRNDEQFL EAFVIFCGLG IQNTQMYEAV ERAMAKQMVT LEVLSYHASA
     AEEETRELQS LAAAVVPSAQ TLKITDFSFS DFELSDLETA LCTIRMFTDL NLVQNFQMKH
     EVLCRWILSV KKNYRKNVAY HNWRHAFNTA QCMFAALKAG KIQNKLTDLE ILALLIAALS
     HDLDHRGVNN SYIQRSEHPL AQLYCHSIME HHHFDQCLMI LNSPGNQILS GLSIEEYKTT
     LKIIKQAILA TDLALYIKRR GEFFELIRKN QFNLEDPHQK ELFLAMLMTA CDLSAITKPW
     PIQQRIAELV ATEFFDQGDR ERKELNIEPA DLMNREKKNK IPNMQVGFID AICLQLYEAL
     THVSKDCFPL LDGCRKNRQK WQALAEQQEK MLINGESSQA KRN
//
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