ID F7D573_HORSE Unreviewed; 540 AA.
AC F7D573;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Neuropilin and tolloid like 1 {ECO:0000313|Ensembl:ENSECAP00000012022.3};
GN Name=NETO1 {ECO:0000313|Ensembl:ENSECAP00000012022.3,
GN ECO:0000313|VGNC:VGNC:20689};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000012022.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000012022.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012022.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000012022.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000012022.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR AlphaFoldDB; F7D573; -.
DR STRING; 9796.ENSECAP00000012022; -.
DR PaxDb; 9796-ENSECAP00000012022; -.
DR Ensembl; ENSECAT00000015000.3; ENSECAP00000012022.3; ENSECAG00000014149.4.
DR VGNC; VGNC:20689; NETO1.
DR GeneTree; ENSGT00940000156700; -.
DR HOGENOM; CLU_015228_0_0_1; -.
DR InParanoid; F7D573; -.
DR OMA; ISMPRIS; -.
DR Proteomes; UP000002281; Chromosome 8.
DR Bgee; ENSECAG00000014149; Expressed in prefrontal cortex and 19 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR GO; GO:0035255; F:ionotropic glutamate receptor binding; IBA:GO_Central.
DR GO; GO:2000463; P:positive regulation of excitatory postsynaptic potential; IBA:GO_Central.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 1.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF27; NEUROPILIN AND TOLLOID-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 48..162
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 179..294
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DISULFID 48..75
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 299..311
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 306..324
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 318..333
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 540 AA; 60646 MW; 68948D971FCEE1BB CRC64;
MGTCGRGWGV GPKESAVVAS LIILHLSGAT KKGTEKQTTS ETQKSVQCGT WTKHAEGGIF
TSPNYPSKYP PDRECIYIIE AAPRQCIELY FDEKYSIEPS WECKFDHIEV RDGPFGFSPI
IGRFCGQQNP PVIKSSGRFL WIKFFADGEL ESMGFSARYN FTPDPDFKDL GVLKPLPACE
FEMGGPEGIV ESIQIMKEGK ASASEAVDCK WYIRAPPRSK IYLRFLDYEM QNSNECKRNF
VAVYDGSSSV GDLKAKFCST VANDVMLRTG LAVIRLWADE GSRNSRFQML FTSFQEPPCE
GNTFFCHSNM CINNTLVCNG LQNCVYPWDE NHCKEKRKAS LLDQLTNTSG TVIGVTSCIV
IILIIISVIV QIKQPRKKYV QRKSDFDQTV FQEVFEPPHY ELCTLRGTGA TADFADVADD
FENYHKLRRS SSKCVHDHHC GSQLSSAKGS RSNLSTRDAS VLTEMPPQPV KPLIPPMNRR
NILVMKHNYS QDAADACDID EIEEVPTTSH RLSRHDKAVQ RFCLIGSLSK HESEYNTTRV
//
