GenomeNet

Database: UniProt
Entry: F7D8R6_MONDO
LinkDB: F7D8R6_MONDO
Original site: F7D8R6_MONDO 
ID   F7D8R6_MONDO            Unreviewed;      1985 AA.
AC   F7D8R6;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   07-JUN-2017, entry version 44.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSMODP00000016737};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000016737, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000016737, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000016737}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000016737}.
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DR   STRING; 13616.ENSMODP00000016737; -.
DR   Ensembl; ENSMODT00000017048; ENSMODP00000016737; ENSMODG00000013384.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; F7D8R6; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000002280; Chromosome 6.
DR   Bgee; ENSMODG00000013384; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    252    272       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    387    415       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    721    739       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    751    772       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    784    801       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    838    858       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    879    898       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    914    937       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1322   1348       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1447   1470       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1529   1547       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1559   1581       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1593   1609       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1646   1669       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1716   1742       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      130    421       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      477    670       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      721    941       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      951   1089       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1260   1478       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1528   1668       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      412    450       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1985 AA;  223202 MW;  32C29BB867FE6D17 CRC64;
     MANFLLPRGA TSFRRFTRES LAAIEKQIAE KQARSVTQDS RDTPLEEEKP RPQLDLQASK
     KLPDLYGNPP RDLIGEPLED LDPFYSTQKT FIVLNKGKTI FRFSATNALY ILSPFHPIRR
     AAVKILVHSY PFHMFIMCTI LTNCVFMAQH EPPGWTKYVE YTFTAIYTFE SLVKILARGF
     CLNAFTFLRD PWNWLDFSVI VMAYTTEFVD LGNVSALRTF RVLRALKTIS MVESLKTIVG
     ALIQSVKKLA DVMVLTVFCL SVFALIGLQL FMGNLRNKCV RNFTIVNGTN GTVVSDDKIW
     ESVETYISSP ENYLLKNGTS DVLLCGNSTD AGSCPEGYLC LKAGENPDHG YTSFDSFGWA
     FLALFRLMTQ DCWERLYQQT LRSAGKIYMI FFMLVIFLGS FYLVNLILAV VAMAYEEQNQ
     ATIAETEEKE KRFQEAMEML KKEHEALTAR GMDTVSRSSF EMSPLAPKTA PDRRSRRRKR
     QSSGTDEGGE DRFPKSDSDD GPRRTALLGV NHAPLRSSLK RRSSHGSVFT FRRRDLGSET
     DFADDEISTP GESESHRASL LVPWPARRPS GQSQPSPGVP GVPSLLHNGK RNSAVDCNGV
     VSLLASRVPE AASPGGSLLS SVILEKPRPP PDTTSVSEEV SKKQLLMPQR LSLEYFEEPH
     ERQRALSAVS VITSALEELE ESHRKCPPCW HRFAQNYLIW ECCPLWLSVK QRVKFVVMDP
     FTDLTITICI VLNTLFMALE HYNMTPDFED MLQVGNLVFT GIFTGEMTFK IIALEPYYYF
     QQGWNIFDSI IVILSLMELG LSRMGNLSLR VFKLAKSWPT LNTLIKIIGN SVGALGNLTL
     VLAIIVFIFA VVGMQLFGKN YSELRHCISD SGLLPRWHMM DFFHAFLIIF RILCGEWIET
     MWDCMEVSGQ SLCLLVFLLV MVIGNLVVLN LFLALLLSSF SADNLTAPDE DGEMNNLQLA
     LARIQRGLRF VKRTTWDFCC SLLRQKKAAP PAPRGLPSCM AGHGSPEPEK GPDTTRKETR
     FDEKKPGAPE GAGREAGNIP GDPESSVHVP IAVAESDIED HEEEEDNSLG TEMESSKQVS
     RHGAAPPTQE GDDVPSSGKP VGRGQALEQP AESGEASFAR SQEIEWKRGR CKETEKWEGA
     GLGSTSRVRG ATPFLEPGDQ LPRSLITERM WRPEGCSKQS PAAAAHGSPS PGDASSAWRE
     EPWSHGFQSC LPWWRAGLAF RIHRSPGHCA GDSFQVLRLK LVSLLKVFYF MRFLLPQLLY
     WGAGWHQLAL TTCPPFVSVQ VSLISLVANT LGFAEMGPIK SLRTLRALRP LRALSRFEGM
     RVVVNALVGA IPSIMNVLLV CLIFWLIFSI MGVNLFAGKF GRCINQTEGD LPLNYTFVNN
     KSECELYNIT GELYWIKVKV NFDNVGAGYL ALLQVATFKG WMDIMYAAVD SRGCEEQPQW
     EYNLYMYLYF VIFIIFGSFF TLNLFIGVII DNFNQQKKKI RGQDIFMTEE QKKYYNAMKK
     LGSKKPQKPI PRPLNKYQGF IFDIVTKQAF DVTIMFLICL NMVTMMVETD DQSPEKISIL
     AKINLLFVGI FTGECVIKVI ALRHYYFTNS WNIFDFVVVI LSIVGTVLSD IIQKYFFSPT
     LFRVIRLARI GRILRLIRGA KGIRTLLFAL MMSLPALFNI GLLLFLTFAN SMLCLSRSPS
     AGWDELLSPI LNTRPPYCDP NLPNTNNSRG NCGSPAVGIL FFVTYIIISF LIVVNMYIAI
     ILENFSVATE ESTEPLSEDD FDMFYEIWEK FDPEATQFIE YSALSDFADA LSDPLRIAKP
     NQISLINMDL PMVSGDRIHC MDILFAFTKR VLGESGEMDA LKIQMEEKFM AANPSKISYE
     PITTTLRRKH EEVSATVIQR AFRRHLLQRS VKHASFLYRQ QTSDGTLSGD DAPEREGLLA
     YTMSAHYSRP SGPSNSVSST SLPPSYDSVT RATSDNIQAR MSEDSRSDDF VDEPTSPDRD
     RESVV
//
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