GenomeNet

Database: UniProt
Entry: F7DBM4_MONDO
LinkDB: F7DBM4_MONDO
Original site: F7DBM4_MONDO 
ID   F7DBM4_MONDO            Unreviewed;       819 AA.
AC   F7DBM4;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   09-JAN-2013, sequence version 2.
DT   30-AUG-2017, entry version 49.
DE   SubName: Full=Two pore segment channel 1 {ECO:0000313|Ensembl:ENSMODP00000004256};
GN   Name=TPCN1 {ECO:0000313|Ensembl:ENSMODP00000004256};
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000004256, ECO:0000313|Proteomes:UP000002280};
RN   [1] {ECO:0000313|Ensembl:ENSMODP00000004256, ECO:0000313|Proteomes:UP000002280}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=17495919; DOI=10.1038/nature05805;
RA   Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L.,
RA   Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J.,
RA   Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A.,
RA   Benos P.V., Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L.,
RA   Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M.,
RA   Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E.,
RA   Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M.,
RA   Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E.,
RA   Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A.,
RA   Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J.,
RA   Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J.,
RA   Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S.,
RA   Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A.,
RA   Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C.,
RA   Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA   Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P.,
RA   Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C.,
RA   Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K.,
RA   Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D.,
RA   Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G.,
RA   Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E.,
RA   Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C.,
RA   Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E.,
RA   Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K.,
RA   Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A.,
RA   Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R.,
RA   Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA   McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA   Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A.,
RA   Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N.,
RA   Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S.,
RA   Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F.,
RA   Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P.,
RA   Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D.,
RA   Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA   Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT   "Genome of the marsupial Monodelphis domestica reveals innovation in
RT   non-coding sequences.";
RL   Nature 447:167-177(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMODP00000004256}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMODP00000004256}.
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DR   RefSeq; XP_007490066.1; XM_007490004.2.
DR   Ensembl; ENSMODT00000004346; ENSMODP00000004256; ENSMODG00000003481.
DR   GeneID; 100028547; -.
DR   KEGG; mdo:100028547; -.
DR   CTD; 53373; -.
DR   eggNOG; ENOG410INF7; Eukaryota.
DR   eggNOG; ENOG410XZT8; LUCA.
DR   GeneTree; ENSGT00530000063660; -.
DR   InParanoid; F7DBM4; -.
DR   KO; K16896; -.
DR   OMA; WLGFHTF; -.
DR   OrthoDB; EOG091G038K; -.
DR   TreeFam; TF328550; -.
DR   Proteomes; UP000002280; Chromosome 3.
DR   Bgee; ENSMODG00000003481; -.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028801; TPC1.
DR   PANTHER; PTHR10037:SF262; PTHR10037:SF262; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002280};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    108    130       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    136    154       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    175    193       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    233    255       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    267    284       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    296    321       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    446    466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    478    496       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    508    527       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    571    594       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    667    692       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      109    331       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      443    691       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   819 AA;  95048 MW;  54407FD575BB4CCF CRC64;
     MAGSMDDDVP FILTLDDNGS TPLAPSDHLD EEDLPNENGG DYIISDLRVA SPDSGDGSSP
     LSPTRPSWEM NYQEAAIYLQ EGENNDKFFT HPKNAHALAA YLFVHNHLFY LMELTTALLL
     LLLSLCEAPA VPALRLGIYV HATLELFALM VVVFELCMKM RWLGFHTFIR HKRTMVKTVV
     LLVQFVEAIV VLVRQTSHVR VTRALRCIFL VDCRYCGAVR RNLRQIFQSL PPFIDILLLL
     LFFMVIFAIL GFYLFSPNSS DPYFSTLENS IVSLFVLLTT ANFPDVMMPS YSRSPWACVF
     FIVYLSIELY FIMNLLLAVV FDTFNDIEKR KFKSLLLHKR TAIQHAYSLL LSQRRPSGIS
     FRQFEGLMRF YKPRMGARER YLTFKALNQS NTPLLSLKDF YDIYEVVALK WKAKRNKEHW
     FDELPRTAFL IFKGINILVK SKGFQYFMYV VVAVNGIWIL VETFMLKGGN FFSKNVPWSY
     IVFLTIYGVE LLLKTTGLGP VEYLTSGWNL FDFSVTAFAF LGLLALAFNM EPFYFIVVLR
     PLQLLRLFKL KKRYRNVLDT MFELLPRMAS LGLTLLIFYY SFAIVGMEFF YGILYPNCCN
     TSTVADSYRW INLTLDNKTS VEEGYYYLNN FDNLLNSFVT LFELTVVNNW YIIMEGVTSQ
     TSHWSRLYFM IFYIVTMVVM TIIVAFILEA FVFRMNYSRK NQDSEVDRGI ILEKDISKEE
     LMAILELYRQ IQGSASDISQ FLKIRSQMDK YGQNSVVFLG RRSKTKSDLS IKMYQEEIKE
     WYEEHARERE LQHRQEGPFS TLPTSQQCPG GRPRSQTII
//
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