ID F7DCK1_XENTR Unreviewed; 329 AA.
AC F7DCK1; F7E7L0; F8V2T4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Nuclear migration protein nudC {ECO:0000256|ARBA:ARBA00017641};
DE AltName: Full=Nuclear distribution protein C homolog {ECO:0000256|ARBA:ARBA00030427};
GN Name=nudc {ECO:0000313|Ensembl:ENSXETP00000044704,
GN ECO:0000313|RefSeq:NP_001240718.1,
GN ECO:0000313|Xenbase:XB-GENE-985468};
GN Synonyms=NudC {ECO:0000313|EMBL:AEI98600.1};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000044704};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000044704}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000044704};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|EMBL:AEI98600.1}
RP NUCLEOTIDE SEQUENCE.
RA Wang Y.;
RT "Molecular cloning and characterization of Xenopus tropicalis nudC gene.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSXETP00000044704}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [4] {ECO:0000313|RefSeq:NP_001240718.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Midbody
CC {ECO:0000256|ARBA:ARBA00004214}.
CC -!- SIMILARITY: Belongs to the nudC family.
CC {ECO:0000256|ARBA:ARBA00010513}.
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DR EMBL; JN010215; AEI98600.1; -; mRNA.
DR RefSeq; NP_001240718.1; NM_001253789.1.
DR STRING; 8364.ENSXETP00000030300; -.
DR PaxDb; 8364-ENSXETP00000044704; -.
DR Ensembl; ENSXETT00000044704; ENSXETP00000044704; ENSXETG00000020686.
DR GeneID; 100380054; -.
DR KEGG; xtr:100380054; -.
DR AGR; Xenbase:XB-GENE-985468; -.
DR CTD; 10726; -.
DR Xenbase; XB-GENE-985468; nudc.
DR eggNOG; KOG2265; Eukaryota.
DR HOGENOM; CLU_047332_1_0_1; -.
DR OMA; QDGPRIQ; -.
DR OrthoDB; 141208at2759; -.
DR TreeFam; TF300147; -.
DR Reactome; R-XTR-141444; Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal.
DR Reactome; R-XTR-2467813; Separation of Sister Chromatids.
DR Reactome; R-XTR-2500257; Resolution of Sister Chromatid Cohesion.
DR Reactome; R-XTR-5663220; RHO GTPases Activate Formins.
DR Reactome; R-XTR-68877; Mitotic Prometaphase.
DR Reactome; R-XTR-9648025; EML4 and NUDC in mitotic spindle formation.
DR Proteomes; UP000008143; Chromosome 2.
DR Bgee; ENSXETG00000020686; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR CDD; cd06492; p23_mNUDC_like; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR032572; NuDC.
DR InterPro; IPR037898; NudC_fam.
DR InterPro; IPR025934; NudC_N_dom.
DR PANTHER; PTHR12356:SF3; NUCLEAR MIGRATION PROTEIN NUDC; 1.
DR PANTHER; PTHR12356; NUCLEAR MOVEMENT PROTEIN NUDC; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF16273; NuDC; 1.
DR Pfam; PF14050; Nudc_N; 1.
DR SUPFAM; SSF49764; HSP20-like chaperones; 1.
DR PROSITE; PS51203; CS; 1.
PE 2: Evidence at transcript level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 165..256
FT /note="CS"
FT /evidence="ECO:0000259|PROSITE:PS51203"
FT REGION 70..169
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 329 AA; 38009 MW; FE4FB33CE531F034 CRC64;
MAASGEDERF DAMLLAMAQQ HEGGVQELVN TFFSFLRRKT DFFVGGENAA AEKLITQAFN
HHNKLALAAQ KQKDADRLER EAVRQEREAK KKETEAGESR ITELTDEEAE RLQKEIDKNK
EKEKATRETE EKPEPEKDGE EEKEEEEEDD EKDKGKLKPN SGNGANLPHY RWTQTLSEVD
LVVPFPVSFR LKGKDVQVDI KRHRLTIGLR GQKPVLDGEL FNDIKVEECS WLIEDGKVVT
VHLEKINTME WWSRVVLTDP EINTKKINPE NSKLSDLDGE TRSMVEKMMY DQRQKSMGLP
TSDEQKKQDI LKKFMEQHPE MDFSKAKFS
//
