ID F7DDR7_HORSE Unreviewed; 1623 AA.
AC F7DDR7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Tyrosine-protein kinase receptor {ECO:0000256|RuleBase:RU000312};
DE EC=2.7.10.1 {ECO:0000256|RuleBase:RU000312};
GN Name=ALK {ECO:0000313|Ensembl:ENSECAP00000005467.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000005467.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000005467.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005467.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000005467.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000005467.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171,
CC ECO:0000256|RuleBase:RU000312};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. Insulin receptor subfamily.
CC {ECO:0000256|RuleBase:RU000312}.
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DR SMR; F7DDR7; -.
DR STRING; 9796.ENSECAP00000005467; -.
DR PaxDb; 9796-ENSECAP00000005467; -.
DR Ensembl; ENSECAT00000007478.4; ENSECAP00000005467.3; ENSECAG00000007080.4.
DR GeneTree; ENSGT00940000159280; -.
DR HOGENOM; CLU_001878_2_1_1; -.
DR InParanoid; F7DDR7; -.
DR OMA; NTACERQ; -.
DR TreeFam; TF351636; -.
DR Proteomes; UP000002281; Chromosome 15.
DR Bgee; ENSECAG00000007080; Expressed in retina and 4 other cell types or tissues.
DR ExpressionAtlas; F7DDR7; baseline.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008201; F:heparin binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0030298; F:receptor signaling protein tyrosine kinase activator activity; IEA:Ensembl.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IBA:GO_Central.
DR GO; GO:0030534; P:adult behavior; IEA:Ensembl.
DR GO; GO:0097009; P:energy homeostasis; IEA:Ensembl.
DR GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR GO; GO:0050995; P:negative regulation of lipid catabolic process; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:Ensembl.
DR GO; GO:1900006; P:positive regulation of dendrite development; IEA:Ensembl.
DR GO; GO:0042127; P:regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0060159; P:regulation of dopamine receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0090648; P:response to environmental enrichment; IEA:Ensembl.
DR GO; GO:0036269; P:swimming behavior; IEA:Ensembl.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR CDD; cd00112; LDLa; 1.
DR CDD; cd06263; MAM; 2.
DR CDD; cd05036; PTKc_ALK_LTK; 1.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR002011; Tyr_kinase_rcpt_2_CS.
DR PANTHER; PTHR24416:SF276; ALK TYROSINE KINASE RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF12810; Gly_rich; 1.
DR Pfam; PF00629; MAM; 2.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50060; MAM_2; 2.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR PROSITE; PS00239; RECEPTOR_TYR_KIN_II; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Kinase {ECO:0000256|ARBA:ARBA00023137};
KW Membrane {ECO:0000256|RuleBase:RU000312};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Phosphoprotein {ECO:0000256|RuleBase:RU000312};
KW Receptor {ECO:0000256|RuleBase:RU000312};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Transmembrane {ECO:0000256|RuleBase:RU000312};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1623
FT /note="Tyrosine-protein kinase receptor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023929305"
FT DOMAIN 271..434
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 485..643
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 1123..1399
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 20..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1419..1469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1488..1544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1488..1516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 1157
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1623 AA; 176599 MW; C167BCAA435C6A7B CRC64;
MGGIGLLWRL LPLLSAAASG SGTGTGTGTG QRMGSPAVGP ALQPREPLSY SRLQRKSLAV
DFVVPSLFRV YARDLLLPPS SASEPRAGRL EARGSLALDC APLLRLVGPP PGVSWTAGAS
SPAPAPARML SRVLKGGSIR KLRRAKQLVL ELGEDAILEG CVGPPEEAAA ELLQFNLSEL
FSWWIRHGEG RLRIRLMPEK KASEVGREGR LSAAIRASQP RLLFQIFGTG HSFLESPTNL
PSLPPDSFAW NLTWIMKDSF PFLSHRSRYG LECSFDFPCE LEYSPPLHDL GNQSWSWRRV
PSEEASQMDL LDGPEAEHSK EMPRGSFLLL NTSANSKHTI LSPWMRSSSE HCRLAVSVHR
HLQPSGRYVA QLLPHNEAGR EILLVPTPGK HGWTVLQGRI GRPENPFRVA LEYISSGNRS
LSAVDFFALK NCSEGTSPGS KMALQSSFTC WNGTVLQLGQ ACDFHRDCNQ GEDEGQLCSK
LPAGFYCNFE DGFCGWTQGA VSPHRPRWQV RTLKDAWFPD HQGHALLLST TDVPTSESAT
VTSATFPAPM KSSPCELRMS WLIRGVLQGN VSLVLVENKT GKEQSRMVWH VATNEGLSLW
QWTVLPLLDV ADRFWLQIVA WWGQGSRATV AFDNISISLD CYLTISGEDK MPQNTAPKSR
NLFERNSNKE SKPWENTPGE TPIFDPTVHW LFTTCGASGP HGPTQAQCNN AYRNSNLSVV
VGSEGPLKGI QTWKVPATDT YSISGYGAAG GKGGKNTMMR SHGVSVLGIF NLEKDDMLYI
LVGQQGEDAC PSTNRLIQKV CIGENNVIEE EIRVNRSVHE WAGGGGGGGG ATYVFKMKDG
VPVPLIIAAG GGGRAYGAKT DTFHPERLEN NSSVLGLNGN SGAAGGGGGW NDNTSLLWSG
KSLLEGATGG HSCPQAMKKW GWETRGGFGG GGGGCSSGGG GGGYIGGNAA SDNDPEMDGE
DGVSFISPLG ILYTPALKVM EGHGEVNIKH YLNCSHCEVD ECHMDPESHK IICFCDHGTV
LAEDGVSCIV SPTPEPHLPL SLILSVVTSA LVAALVLAFS GIMIVYRRKH QELQAMQMEL
QSPEYKLSKL RTSTIMTDYN PNYCFAGKTS SISDLKEVPR KNITLIRGLG HGAFGEVYEG
QVSGMPNDPS PLQVAVKTLP EVCSEQDELD FLMEALIISK FNHQNIVRCI GVSLQALPRF
ILLELMAGGD LKSFLRETRP RPNQPSSLAM LDLLHVAQDI ACGCQYLEEN HFIHRDIAAR
NCLLTCPGPG RVAKIGDFGM ARDIYRASYY RKGGCAMLPV KWMPPEAFME GIFTSKTDTW
SFGVLLWEIF SLGYMPYPSK SNQEVLEFVT SGGRMDPPKN CPGPVYRIMT QCWQHQPEDR
PNFAIILERI EYCTQDPDVI NTALPIEYGP LVEEEEKVPM RPKDPEGMPP LLVSPPQAKR
EEGQGPAAPL PLPSTSSSKA MKKPTAAEIS VRVTRAPAVE GGHVNMAFSQ SNPPSELHKV
QGSRNKPTSL WNPTYGSWFT EKPAKKNNPP AKMEQQERGN LGREGSCTVP PNMAAGRLPG
ASLLLEPSSL TANMKEVPLF RLRHFPCGNV NYGYQQQGLP LEATPAPGTS HYEDAILKTQ
PGP
//
