ID F7DG08_MONDO Unreviewed; 1102 AA.
AC F7DG08;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 27-JUL-2011, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Ubiquitin specific peptidase 8 {ECO:0000313|Ensembl:ENSMODP00000002705.2};
GN Name=USP8 {ECO:0000313|Ensembl:ENSMODP00000002705.2};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000002705.2, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000002705.2, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000002705.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_001370028.1; XM_001369991.4.
DR RefSeq; XP_007480000.1; XM_007479938.2.
DR AlphaFoldDB; F7DG08; -.
DR STRING; 13616.ENSMODP00000002705; -.
DR Ensembl; ENSMODT00000002760.4; ENSMODP00000002705.2; ENSMODG00000002220.4.
DR GeneID; 100026038; -.
DR KEGG; mdo:100026038; -.
DR CTD; 9101; -.
DR eggNOG; KOG1868; Eukaryota.
DR GeneTree; ENSGT00940000157542; -.
DR HOGENOM; CLU_009980_0_0_1; -.
DR InParanoid; F7DG08; -.
DR OMA; TCNKESA; -.
DR OrthoDB; 227085at2759; -.
DR TreeFam; TF106277; -.
DR Proteomes; UP000002280; Chromosome 1.
DR Bgee; ENSMODG00000002220; Expressed in spermatocyte and 20 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043197; C:dendritic spine; IBA:GO_Central.
DR GO; GO:0005769; C:early endosome; IEA:Ensembl.
DR GO; GO:0019897; C:extrinsic component of plasma membrane; IBA:GO_Central.
DR GO; GO:0030496; C:midbody; IBA:GO_Central.
DR GO; GO:0014069; C:postsynaptic density; IBA:GO_Central.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IBA:GO_Central.
DR GO; GO:1990380; F:K48-linked deubiquitinase activity; IEA:Ensembl.
DR GO; GO:0061578; F:K63-linked deubiquitinase activity; IEA:Ensembl.
DR GO; GO:0007032; P:endosome organization; IBA:GO_Central.
DR GO; GO:0000281; P:mitotic cytokinesis; IEA:Ensembl.
DR GO; GO:1905166; P:negative regulation of lysosomal protein catabolic process; IEA:Ensembl.
DR GO; GO:1905908; P:positive regulation of amyloid fibril formation; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0019538; P:protein metabolic process; IEA:UniProt.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR CDD; cd02674; Peptidase_C19R; 1.
DR CDD; cd22265; UDM1_RNF168; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR Gene3D; 3.40.250.10; Rhodanese-like domain; 1.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR InterPro; IPR015063; USP8_dimer.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR InterPro; IPR048498; WW_USP8.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF27; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 8; 1.
DR Pfam; PF00581; Rhodanese; 1.
DR Pfam; PF00443; UCH; 1.
DR Pfam; PF08969; USP8_dimer; 1.
DR Pfam; PF20625; WW_USP8; 1.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF52821; Rhodanese/Cell cycle control phosphatase; 1.
DR SUPFAM; SSF140856; USP8 N-terminal domain-like; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002280}.
FT DOMAIN 193..311
FT /note="Rhodanese"
FT /evidence="ECO:0000259|PROSITE:PS50206"
FT DOMAIN 761..1093
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 121..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 664..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..144
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..562
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..699
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1102 AA; 124846 MW; C13FCA59D8731996 CRC64;
MPAVASVPKE LYLGSSLKEL NKKTEVKAEK ISTKNYVQSA LKIFRTAEEC RLDRDEEKAY
VLYMKYVAVY NLIKKRPDFK QQQDYFHSML GPANIKKAIE EAERLSESLK LRYEEAEVRK
KLEEKDRREE QQLQQKKEAG QEDGRVSAKS SLENVLDSKD KTKKINGEKK EKNEKAKKGA
VTAEELFTMM TDKNISLIIM DARSIQDYQD SCIINSLSVP EEAINPGVTA NSIEAKLPDN
SKDAWKKRGC VDYVVLLDWF SSAKDLQLGT TLQSLKDALF KWESKTILKN EPLVLEGGYE
NWLLCYPQFT TNAKVIPPAR GKAEEVSISL DFTYPSLEEP IPVHPVAPMP PFPVTINENA
ELGSNQERMG SLSVLTPIGP VATASKSDGS SVPNSICIVK NVPQIDRTKK PSTKLPDDHH
RPKSEAMDLD HQPPQNGKVV PDRSTKPTYA PVVDALTEEE KLRIHAETTL LIEKSKREKE
LRERRQEEQK EKLKKEEQEQ KARENLETEE REEGARSQQA DEESDKKEAK EAGGVKGSAK
KEHEIAETAK PMEDREKGCQ TPEVQKKPVA DVAHSSGLAD PGSSKPANVK GQPEIGIPKA
GTFSETTEDN EKPKSQREPL TRARSEEMGR IVPGLPLGWA KFLDPITGTF RYYHSPTNSV
HMYPPEMAPS SAPTSTPPTH KAKPQVPAER DREPSKLKRS YSSPDITQAI QEEEKKKPTV
TPAVNRENKP LCYPKAEISR LSASQIRNLN PVFGGSGPAL TGLRNLGNTC YMNSILQCLC
NAPHLADYFN RNFYQDDINR SNLLGHKGEV AEEFGIIMKA LWTGQYRYIS PKDFKITIGK
INDQFSGYSQ QDSQELLLFL MDGLHEDLNK ADNRKRHKEE NNDHLDDFKA AEHAWQKHKQ
LNESIIVALF QGQFKSTVQC LTCHKKSRTF EAFMYLSLPL ASTSKCTLQD CLRLFSKEEK
LTDNNRFYCS HCKTRRDSMK KIEIWKLPPV LLVHLKRFSY DGRWKQKLQT SVDFPLESLD
LSQYVIGPKN NLKRYNLFSV SNHYGGLDGG HYTAYCKNAA RQRWFKFDDH EVSDISVSSV
RSSAAYILFY TSLEQRVTDV AT
//
