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Database: UniProt
Entry: F7DI86_HORSE
LinkDB: F7DI86_HORSE
Original site: F7DI86_HORSE 
ID   F7DI86_HORSE            Unreviewed;       715 AA.
AC   F7DI86;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-SEP-2017, entry version 44.
DE   SubName: Full=Two pore segment channel 2 {ECO:0000313|Ensembl:ENSECAP00000017416};
GN   Name=TPCN2 {ECO:0000313|Ensembl:ENSECAP00000017416};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017416, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000017416, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017416,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000017416}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017416};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000017416}.
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DR   STRING; 9796.ENSECAP00000017416; -.
DR   PaxDb; F7DI86; -.
DR   Ensembl; ENSECAT00000021164; ENSECAP00000017416; ENSECAG00000019619.
DR   eggNOG; ENOG410KCTV; Eukaryota.
DR   eggNOG; ENOG4111V21; LUCA.
DR   GeneTree; ENSGT00530000063660; -.
DR   InParanoid; F7DI86; -.
DR   OMA; SSVIWVN; -.
DR   OrthoDB; EOG091G045K; -.
DR   TreeFam; TF328550; -.
DR   Proteomes; UP000002281; Chromosome 12.
DR   Bgee; ENSECAG00000019619; -.
DR   GO; GO:0010008; C:endosome membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0072345; F:NAADP-sensitive calcium-release channel activity; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0006816; P:calcium ion transport; IBA:GO_Central.
DR   GO; GO:0007040; P:lysosome organization; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0010506; P:regulation of autophagy; IEA:Ensembl.
DR   GO; GO:0006939; P:smooth muscle contraction; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR028798; TPC2.
DR   PANTHER; PTHR10037:SF270; PTHR10037:SF270; 1.
DR   Pfam; PF00520; Ion_trans; 2.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     41     64       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    123    145       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    184    203       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    251    276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    397    419       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    431    450       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    462    487       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    507    524       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    545    565       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    635    657       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       55    279       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      395    660       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   715 AA;  81705 MW;  163A78FB78273FA5 CRC64;
     AGAEARRALC FDQAVVFIED AIQYRSIHHR VDSSSLRLYR WYYSDACQWA LCLTIFLILF
     LAFIETPSSL TRTADVRYRS APWQPPCGLT ESIELLCLLV FVADVSVKSY LVGWAEFWKN
     LWLQAYLLVL VVSLLDWTVS LSLVCQEVAR ERPALRPAFL LRVPGQITRR LLVTRWAMCP
     SPSVLLLLAL HLCLFTMFGM LLFTGEKDDG QAQERLTYFR NLPEALTSLL VLLTTANNPD
     VMIPAYSKHR AYAIFFVVFT LIGSLFLMNL LTAIIYNQFR GYLMKSLQTS LLRRRLGTWA
     AYQVLCSLSA EGGAAAQGVG VKAQDVLQVL HKVQLAGSHK QAIVEKLRSY GGDMMSADEF
     QKLFHEFDKR VIKQHPPRPE YQSPFLRSAQ FLFSHRYFDY LGNLVALGNL VSICVFLVRD
     ADVLPGDRDD FVLGILNCIF ILYYLLEMLL KLFALGLRGY LVFLSNVFDG LLTIVLLVLE
     ISTLAVYRFP HPGWYPEMLG LLSLWDMTRL VNMLIVFRFL RIIPSMKLMA VVASTILDLI
     KNMRAFGGIL VVVYYVFAIV GISLFRGVVV APGNSSLALD NGSAPCGSFE QLEYWPNNFD
     DFAAALITLW DVMVVNNWQV FLDAYRRYAG PWSKVYFVLW WLVSSVIWVN LFLALILENF
     LHKWDRRSHL QSLAGDPEAP YQMTVELLFR DVLEEPTEEE LLAELSHHPH LRLRR
//
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