ID F7DII4_HORSE Unreviewed; 1112 AA.
AC F7DII4;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Abelson helper integration site 1 {ECO:0000313|Ensembl:ENSECAP00000017407.3};
GN Name=AHI1 {ECO:0000313|Ensembl:ENSECAP00000017407.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017407.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000017407.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017407.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000017407.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017407.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; F7DII4; -.
DR STRING; 9796.ENSECAP00000017407; -.
DR PaxDb; 9796-ENSECAP00000017407; -.
DR Ensembl; ENSECAT00000021153.3; ENSECAP00000017407.3; ENSECAG00000019646.4.
DR GeneTree; ENSGT00940000156509; -.
DR InParanoid; F7DII4; -.
DR OMA; IMTQPCD; -.
DR TreeFam; TF329226; -.
DR Proteomes; UP000002281; Chromosome 10.
DR ExpressionAtlas; F7DII4; baseline.
DR GO; GO:0005912; C:adherens junction; ISS:UniProtKB.
DR GO; GO:0005911; C:cell-cell junction; ISS:UniProtKB.
DR GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0005929; C:cilium; ISS:UniProtKB.
DR GO; GO:0097730; C:non-motile cilium; ISS:UniProtKB.
DR GO; GO:0007417; P:central nervous system development; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0035844; P:cloaca development; ISS:UniProtKB.
DR GO; GO:0001947; P:heart looping; ISS:UniProtKB.
DR GO; GO:0030902; P:hindbrain development; ISS:UniProtKB.
DR GO; GO:0070121; P:Kupffer's vesicle development; ISS:UniProtKB.
DR GO; GO:0070986; P:left/right axis specification; ISS:UniProtKB.
DR GO; GO:0001738; P:morphogenesis of a polarized epithelium; ISS:UniProtKB.
DR GO; GO:0044458; P:motile cilium assembly; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
DR GO; GO:0071599; P:otic vesicle development; ISS:UniProtKB.
DR GO; GO:0035845; P:photoreceptor cell outer segment organization; ISS:UniProtKB.
DR GO; GO:0030862; P:positive regulation of polarized epithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0039023; P:pronephric duct morphogenesis; ISS:UniProtKB.
DR GO; GO:0039008; P:pronephric nephron tubule morphogenesis; ISS:UniProtKB.
DR GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR GO; GO:0050795; P:regulation of behavior; ISS:UniProtKB.
DR GO; GO:0010842; P:retina layer formation; ISS:UniProtKB.
DR GO; GO:0065001; P:specification of axis polarity; ISS:UniProtKB.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISS:UniProtKB.
DR GO; GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
DR CDD; cd11812; SH3_AHI-1; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR035832; AHI1_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44499; JOUBERIN; 1.
DR PANTHER; PTHR44499:SF1; JOUBERIN; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 548..580
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 591..633
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 749..778
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 967..1027
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..82
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1112
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..18
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..224
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1048..1062
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1106
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1112 AA; 127155 MW; 3E102F46B800436A CRC64;
MRVTKNKLRN PQSTPENPED VSVEEDKQEK ASKKVLKTVL QVTAPEVEME TPEKKGDSTP
QKARVKSQPG VTQQDSAKAS EEEELMQVYQ LQVAEEMAKE IKKKIRKKLK EQLTYFPSDT
SLHDDKLSSE KRKKKKKKVP VLSKAETSTL PISDDAVEGE PRKESPVGAV TSDSHQDDEI
NSVGQNVEDS MQDDTKSKPK KKKKKAKTVS DDNEDTDGDG VHEITSRDSP VYPKCLLDDD
LVLGVYIHRT DRLKSDFMIS HPMVKIHVVD ENTGHYVKKD DSERPVSSYY EKENVDYILP
IMTQPYDFKQ LKSRLPEWEE QIIFNENFPY LLRDFDESPK VILFFEILDF LSMDEIRNNS
EFQNQECGFR KIAWAFLKLL GANGNVNINS KLRLQLYYPP TKPRSQSDVV EVFEWWSKCP
RNRYPSTLYV TVRGLKVPDC IKPSYRSMMA LQEEKGKPVY CERHHEPSSV DTEPGLEDSK
EEVKWRRLPG QACRIPNKHL FSLNAGERGC FCLAFSHNGR ILAAACASRD GYPIILYEIP
SGRFMRELCG HLNIIYDLCW SKDDRYVLTA SSDGTARIWK NEVNNTNTFR VLPHPSFVYT
AKFHPAVKEL VVTGCYDSVI RVWKVDMREE PAILIRQFDT HRSFINSLCF DFEGHHMYSG
DCAGVVVVWN TYVKVGDVQH SVRHWSVTQE IKESEFKGIP ISYLEVHPNG KRLLIHTKDS
TLRIMDLRIL AARKFVGAAN YREKIHSTLT PCGTFLFAGS EDAIVYVWNP ETGEQVAMYS
DLPFKSPIRD ISYHPLENMV AFCAFGQNEP LLLYIYDFHV AQQEAEMFKR YNGTFPLPGI
HQSQDALCTC PKLPHQGSFQ IDDYVHTENS SMKMQQVKQR LDSVTEVIRA CAAKVNKNLS
FPSTSASSQQ SKLKQPNVLA AHQILRQFGF PETGCLIPAH ADTGNARFIH TFRIFSIERK
PCNHHVDTAP TVVALYDYTA NRSDELTIHR GDIIRVFFKD NEDWWYGSVG KGQEGYFPAN
HVASETLYQE LPPEIKERSP PLTPTEKTKM EKPSSAPQKS VIKDKSQDFR LGSESMTHSE
AGKEQSREDR GHTVDMPVKR NEQTGRKVTL IE
//
