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Database: UniProt
Entry: F7DPH0_XENTR
LinkDB: F7DPH0_XENTR
Original site: F7DPH0_XENTR 
ID   F7DPH0_XENTR            Unreviewed;       838 AA.
AC   F7DPH0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   28-MAR-2018, entry version 39.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=atp6v0a4 {ECO:0000313|Ensembl:ENSXETP00000025320};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000025320, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000025320}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000025320};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000025320}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; AAMC01102827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01102828; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01102829; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01102830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01102831; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; F7DPH0; -.
DR   STRING; 8364.ENSXETP00000025320; -.
DR   PaxDb; F7DPH0; -.
DR   Ensembl; ENSXETT00000025320; ENSXETP00000025320; ENSXETG00000011571.
DR   Xenbase; XB-GENE-493197; atp6v0a4.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; F7DPH0; -.
DR   OMA; FLNTFKM; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Reactome; R-XTR-1222556; ROS, RNS production in phagocytes.
DR   Reactome; R-XTR-77387; Insulin receptor recycling.
DR   Reactome; R-XTR-917977; Transferrin endocytosis and recycling.
DR   Reactome; R-XTR-983712; Ion channel transport.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000011571; -.
DR   ExpressionAtlas; F7DPH0; baseline.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 3.
DR   PIRSF; PIRSF001293; ATP6V0A1; 3.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    392    421       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    441    460       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    539    560       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    566    590       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    635    656       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    772    794       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   838 AA;  94615 MW;  D6185B3C11DDC7AA CRC64;
     MASLFRSEEM SLTQLILQVE AGYCCIAELG ELGLVQFRDL NASVNSFQRR FVNEVRRCEN
     MERILREIIG TTGTGGINAC EPSACAGHLQ TRALLPNITI CTGMGPIIQN ARDLGFVLRN
     GTGRCNFFYS VLYMGPCVLQ AEANLPDDFF SEDTSSLLEL RTIPSAAAAG KLGFTAGVIN
     RERMATFERL LWRVCRGNIY LKYTELDTAL EDPVTKEEVK KNVFIIFYQG DQLKLKIKKI
     CDGSVTGILC QMKKISNSKH FIVMCNCHCV FMCNCHCVCP FPFPALLVLT PDTTPQYPFI
     PHSHWVYVMC NCHCVFMCNC HCVCPFPFPA LLVLTPDTTP QYPFIPHSHW VYSYLDPPTF
     NRTNKFTSGF QNIVNAYGVG SYREMNPTPY TIITFPFLFA VMFGDCGHGS VMLGFALWMV
     LNEKQLLASK TDNEIWNTFF GGRYLILLMS IFSIYTGFIY NDCFSKSFDI FGSSWRVRPM
     FINKTWNDNL VHQGLQLQLD PAVPGVYSGN PYPFGIDPIW NIAQNKLTFL NSYKMKMSVV
     MGITQMVFGV MLGLLNHINF KRPINIILQF IPEMIFIICL FGYLVFMIIF KWCKYDVHSS
     QGAPSILIHF INMFLFNYSD PTNAPLYEHQ KEVQTFLVIF ALIAVPWMLL IKPFVLRANH
     LKAQRMLQSS SGPEDHAELT DVENAHANHK SKKEEHGGGD HGGGHGEHGE EFDFGDIFVH
     QAIHTIEYCL GCISNTASYL RLWALSLAHA QLSEVLWTMV MHQGLSIGGY GGLIGVFIIF
     AAFAVLTVAI LLVMEGLSAF LHALRLHWVE FQNKFYAGTG HLFSPFSFQS ILEGTDNE
//
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