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Database: UniProt
Entry: F7DQI7_HORSE
LinkDB: F7DQI7_HORSE
Original site: F7DQI7_HORSE 
ID   F7DQI7_HORSE            Unreviewed;       826 AA.
AC   F7DQI7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   30-AUG-2017, entry version 34.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=TCIRG1 {ECO:0000313|Ensembl:ENSECAP00000008736};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000008736, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000008736, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008736,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000008736}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000008736};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000008736}.
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DR   STRING; 9796.ENSECAP00000008736; -.
DR   PaxDb; F7DQI7; -.
DR   Ensembl; ENSECAT00000011204; ENSECAP00000008736; ENSECAG00000010196.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; F7DQI7; -.
DR   OMA; WRACRGF; -.
DR   OrthoDB; EOG091G031W; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000002281; Chromosome 12.
DR   Bgee; ENSECAG00000010196; -.
DR   ExpressionAtlas; F7DQI7; baseline.
DR   GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0016471; C:vacuolar proton-transporting V-type ATPase complex; IBA:GO_Central.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0051117; F:ATPase binding; IBA:GO_Central.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IBA:GO_Central.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0015986; P:ATP synthesis coupled proton transport; IBA:GO_Central.
DR   GO; GO:0016236; P:macroautophagy; IEA:Ensembl.
DR   GO; GO:0007039; P:protein catabolic process in the vacuole; IEA:Ensembl.
DR   GO; GO:0007035; P:vacuolar acidification; IBA:GO_Central.
DR   GO; GO:0070072; P:vacuolar proton-transporting V-type ATPase complex assembly; IBA:GO_Central.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 2.
DR   PIRSF; PIRSF001293; ATP6V0A1; 2.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    397    422       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    443    460       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    536    554       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    574    592       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    635    655       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    766    791       Helical. {ECO:0000256|RuleBase:RU361189}.
SQ   SEQUENCE   826 AA;  92429 MW;  027A559C2C22EA9C CRC64;
     MGSMFRSEEV ALVQLFLPTA AAYTCVSQLG ELGLVEFRDL NASVSAFQRR FVMDVRRCEE
     LEKTFTFLQE EVWRAGLALS PPEGALPAPP PRDLLRIQEE TDRLAQELRD VRGNQQTLRA
     QLHQLQLHEA VLGQGHCPPL VATDTDRSSE RTPLLQDPRG PHQDLRVNFV ASAVEPHKAA
     ALERLLWRAC RGFLIASFRE TEQPLQDPVT GEPATWMTFL ISYWGEQIGQ KILKITNCFH
     CHVFPFEEQE EARHAALQQL QQQTHELLEV LETERFLSQE PSLVARASPP LTPRAPGMGH
     HRLLAHSTCS TVTTGLPVLG HLERQVPGGP SLRLTFLSVC LEAGVSAVVH RPCRDMPPTL
     VRTNRFTASF QGIVDAYGVG RYQEVNPAPY TIVTFPFLFA VMFGDVGHGL LMFLFALAMV
     LAENRPAVKT AQNEIWRTFF GGRYLLLLMG LFSVYTGFIY NECFSRATVI FRSGWNVSAM
     VDQSGWSDEF LAQHPLLTLD PNVSGVFRGP YPFGIDPVWS LAVNHLSFLN SFKMKMSVIL
     GVTHMAFGVV LGVFNHLHFR QPYRLLLETL PELVFLLGLF GYLVFLVFYK WLCYTSASAA
     SAPSILIHFI NMFLFSRSPT NRPLFTGQEM VQSALVVLGP AMVPVLLLGT PLFLFRQHRR
     RSRKRPTGRQ LDEDQTGLLD ASNPSEAAWG SDEEKAGCPG PEEEAEFVPS EVVMHQAIHT
     IEFCLGCISN TASYLRLWAL SLAHAQLSEV LWAMVMRTGL RMGNKIGVMA VVLVPIFAAF
     AVLTVAILLV MEGLSAFLHA LRLHWVEFQN KFYSGTGYKL SPFSFA
//
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