ID F7DT46_MONDO Unreviewed; 697 AA.
AC F7DT46;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=EEF1A lysine and N-terminal methyltransferase {ECO:0000313|Ensembl:ENSMODP00000004758.3};
GN Name=METTL13 {ECO:0000313|Ensembl:ENSMODP00000004758.3};
OS Monodelphis domestica (Gray short-tailed opossum).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX NCBI_TaxID=13616 {ECO:0000313|Ensembl:ENSMODP00000004758.3, ECO:0000313|Proteomes:UP000002280};
RN [1] {ECO:0000313|Ensembl:ENSMODP00000004758.3, ECO:0000313|Proteomes:UP000002280}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=17495919; DOI=10.1038/nature05805;
RA Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S.,
RA Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M.,
RA Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.,
RA Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E.,
RA Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A.,
RA Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S.,
RA Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E.,
RA Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K.,
RA VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C.,
RA Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P.,
RA Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A.,
RA Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L.,
RA Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S.,
RA Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M.,
RA D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K.,
RA Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J.,
RA Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A.,
RA Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R.,
RA Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y.,
RA Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C.,
RA McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O.,
RA Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L.,
RA Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C.,
RA Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L.,
RA Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F.,
RA Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T.,
RA Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J.,
RA Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S.,
RA Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I.,
RA Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M.,
RA Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D.,
RA Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J.,
RA Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M.,
RA Samollow P.B., Lander E.S., Lindblad-Toh K.;
RT "Genome of the marsupial Monodelphis domestica reveals innovation in non-
RT coding sequences.";
RL Nature 447:167-177(2007).
RN [2] {ECO:0000313|Ensembl:ENSMODP00000004758.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_001364975.1; XM_001364938.2.
DR AlphaFoldDB; F7DT46; -.
DR STRING; 13616.ENSMODP00000004758; -.
DR Ensembl; ENSMODT00000004861.4; ENSMODP00000004758.3; ENSMODG00000003886.4.
DR GeneID; 100015352; -.
DR KEGG; mdo:100015352; -.
DR CTD; 51603; -.
DR eggNOG; KOG2352; Eukaryota.
DR GeneTree; ENSGT00510000047399; -.
DR HOGENOM; CLU_010025_1_0_1; -.
DR InParanoid; F7DT46; -.
DR OMA; REIEWLF; -.
DR OrthoDB; 179741at2759; -.
DR TreeFam; TF105906; -.
DR Proteomes; UP000002280; Chromosome 2.
DR Bgee; ENSMODG00000003886; Expressed in hindlimb bud and 17 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:1902807; P:negative regulation of cell cycle G1/S phase transition; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd02440; AdoMet_MTases; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR025714; Methyltranfer_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR NCBIfam; NF037959; MFS_SpdSyn; 1.
DR PANTHER; PTHR12176; SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN; 1.
DR PANTHER; PTHR12176:SF88; SPERMINE_SPERMIDINE SYNTHASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G08500); 1.
DR Pfam; PF13847; Methyltransf_31; 1.
DR Pfam; PF01564; Spermine_synth; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
PE 4: Predicted;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000002280};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 47..162
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13847"
FT REGION 428..462
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 697 AA; 78722 MW; F884D46D0C155682 CRC64;
MNLLPKSSKE FGSVDYWEKF FQQRGKKAFE WYGSYLDLCG VLHKYIKAKD KVLVVGCGNS
ELSEQLYDVG YQDIVNIDIS EVVIKQMKER NASRRPQMSF LQMDMTKMEF PDASFQVVLD
KGTLDAILTD EEEKTLEKVD KMLAEVGRVL QVGGRYLCIS LAQAHILKKI VGYFSKEGWM
VRVHQVTSSQ NPSSEAEPQF SLPVFAFIMT KFRPVSGSAL QILELCAQEQ VKPVRLENTE
RLAEAVRERQ RYAWLRNQLN RKTGPASVSL DLCDGSTGEP RYTLHVVDSP TVKLSRDNHF
AIFIIPQGRE TEWLFGMEEG RKQLAASAGF RRLITVALHR DQQYQGMDSI QAELSGKVME
LAPPGLPAQQ QVPFLSVGGD IGVRTIQHRD RSSLSGDYVI EDVQGDDRRY FRRLIFLSNR
NVVQSEARLL TDTPHRAQKK RKKDKKRLQP ADTPENPVPA RQPIDKSFLC CEHHKAMIAG
LALLKNPERL PEAPLALLVV GLGGGSLPLF IHDHFLKSHI DAVEIDPSML EVATHWFGFT
QSDRMKVHIA DGLDYITNLA KGEQLHYDVI MFDVDSKDPT VGMSCPPPAF VDHAFLQNVK
RILTPEGVFI LNLVCRDSGL KDSVLAGLKK VFPLLYVRQI EGEVNEILFC QLQPEHKLAT
PELLEMAQAL ERTLRKPGNG FDSTYVLSDM LKTVKIV
//
