ID F7DVV2_HORSE Unreviewed; 1023 AA.
AC F7DVV2;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Guanylate cyclase {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202, ECO:0000256|RuleBase:RU003431};
GN Name=NPR1 {ECO:0000313|Ensembl:ENSECAP00000000846.3,
GN ECO:0000313|VGNC:VGNC:58674};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000000846.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000000846.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000846.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000000846.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000000846.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|RuleBase:RU003431};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
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DR AlphaFoldDB; F7DVV2; -.
DR STRING; 9796.ENSECAP00000000846; -.
DR PaxDb; 9796-ENSECAP00000000846; -.
DR Ensembl; ENSECAT00000001052.3; ENSECAP00000000846.3; ENSECAG00000000954.4.
DR VGNC; VGNC:58674; NPR1.
DR GeneTree; ENSGT00940000156223; -.
DR HOGENOM; CLU_001072_11_0_1; -.
DR InParanoid; F7DVV2; -.
DR OMA; KCAYEKS; -.
DR OrthoDB; 3683909at2759; -.
DR TreeFam; TF106338; -.
DR Proteomes; UP000002281; Chromosome 5.
DR Bgee; ENSECAG00000000954; Expressed in chorionic villus and 17 other cell types or tissues.
DR ExpressionAtlas; F7DVV2; baseline.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IBA:GO_Central.
DR GO; GO:0001653; F:peptide receptor activity; IBA:GO_Central.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006182; P:cGMP biosynthetic process; IBA:GO_Central.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0007168; P:receptor guanylyl cyclase signaling pathway; IBA:GO_Central.
DR CDD; cd07302; CHD; 1.
DR CDD; cd06385; PBP1_NPR_A; 1.
DR CDD; cd14042; PK_GC-A_B; 1.
DR Gene3D; 3.40.50.2300; -; 3.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR001170; ANPR/GUC.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR11920:SF300; ATRIAL NATRIURETIC PEPTIDE RECEPTOR 1; 1.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00255; NATPEPTIDER.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00458; ANF_RECEPTORS; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 3: Inferred from homology;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293,
KW ECO:0000256|RuleBase:RU003431}; Coiled coil {ECO:0000256|SAM:Coils};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..1023
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040268610"
FT TRANSMEM 469..491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 469..767
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 838..968
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 775..806
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1023 AA; 114539 MW; 4EA22F0D5ED8A35C CRC64;
MQCPGRPAGA RLRLFLLLLP LLLLPGSRAG NLTVAVVLPL TNTSYPWSWA RVGPAVELAL
AGVKARPDLL PGWTVRTVLG SSENALGVCS DTAAPLAAVD LKWEHNPAVF LGPGCVYAAA
PVGRFTAHWR VPLLTAGAPA LGFGAKDEYA LTTRTGPSHA KLGDFVAALH RRLGWERQAL
VLYAYQPGND QPCFFVVEGL YMRVRDRLNI TVDHLEFAEG DHDHYTMLLR TVGRKGRVIY
ICSSPDTFRT LMLLALEAGL SGENYVFFHL DLFGQSLQGA HGLAPRRPWE RGDGHDVSAH
QAFQAAKIIT YKEPDNPEYL EFLQKLKHLV HEQFNFTLED GLVNTIPASF HDGLLLYVQA
VTETLAHGGT VTDGEGITQR MWNRSFQGVT GYLKMDSNGD RETDFSLWDM DPETGAFRVV
LNYNGTSQEL VAMSGRNLNW PLGYPPPDIP KCGFDNEDPA CNQDHFSTLV VLALVGSLSL
LSILIVSFFI YRKMQLEKEL ASELWRVRWE DVQPSSLERH LRSAGSRLTL SGRGSNYGSL
LTTEGQFQVF AKTAYYKGNL VAVKRLNRKR IELTRKVLFE LKHDILENES ITLDWMFRYS
LTNDIVKGML FLHNGAICSH GNLKSSNCVV DGRFVLKITD YGLESFRDLE TEQGHTLYAK
KLWTAPELLR MASPPARGSQ AGDVYSFGII LQEIALRSGV FHVEGLDLSP KEIIERVTRG
EQPPFRPSLA LQSHLEELGQ LMQRCWAEDP QERPPFQQIR LMLRKFNREH SSNILDNLLS
RMEQYANNLE ELVEERTQAY LEEKRKAEAL LYQILPHSVA EQLKRGETVQ AEAFDSVTIY
FSDIVGFTAL SAESTPMQVV TLLNDLYTCF DAVIDNFDVY KVETIGDAYM VVSGLPVRNG
RLHAREVARM ALALLDAVRS FRIRHRPHEQ LRLRIGIHTG PVCAGVVGLK MPRYCLFGDT
VNTASRMESN GEALKIHLSS ETKAVLEEFG GFELELRGDV EMKGKGKVRT YWLLGEWGSS
TRG
//
