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Database: UniProt
Entry: F7DZR3_HORSE
LinkDB: F7DZR3_HORSE
Original site: F7DZR3_HORSE 
ID   F7DZR3_HORSE            Unreviewed;       530 AA.
AC   F7DZR3;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   27-SEP-2017, entry version 48.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSECAP00000002012};
GN   Name=KCNA6 {ECO:0000313|Ensembl:ENSECAP00000002012};
OS   Equus caballus (Horse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000002012, ECO:0000313|Proteomes:UP000002281};
RN   [1] {ECO:0000313|Ensembl:ENSECAP00000002012, ECO:0000313|Proteomes:UP000002281}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002012,
RC   ECO:0000313|Proteomes:UP000002281};
RX   PubMed=19892987; DOI=10.1126/science.1178158;
RG   Broad Institute Genome Sequencing Platform;
RG   Broad Institute Whole Genome Assembly Team;
RA   Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA   Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
RA   Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
RA   Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
RA   Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
RA   Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
RA   Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
RA   Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
RA   Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
RA   Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
RA   White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT   "Genome sequence, comparative analysis, and population genetics of the
RT   domestic horse.";
RL   Science 326:865-867(2009).
RN   [2] {ECO:0000313|Ensembl:ENSECAP00000002012}
RP   IDENTIFICATION.
RC   STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000002012};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the potassium channel family.
CC       {ECO:0000256|SAAS:SAAS00692852}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSECAP00000002012}.
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DR   RefSeq; NP_001243859.1; NM_001256930.1.
DR   RefSeq; XP_005610870.1; XM_005610813.2.
DR   ProteinModelPortal; F7DZR3; -.
DR   STRING; 9796.ENSECAP00000002012; -.
DR   PaxDb; F7DZR3; -.
DR   Ensembl; ENSECAT00000002809; ENSECAP00000002012; ENSECAG00000002941.
DR   GeneID; 100051577; -.
DR   KEGG; ecb:100051577; -.
DR   CTD; 3742; -.
DR   eggNOG; KOG1545; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00760000118846; -.
DR   InParanoid; F7DZR3; -.
DR   KO; K04879; -.
DR   OMA; GKPEFSE; -.
DR   OrthoDB; EOG091G10NU; -.
DR   TreeFam; TF313103; -.
DR   Proteomes; UP000002281; Chromosome 6.
DR   Bgee; ENSECAG00000002941; -.
DR   GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR   GO; GO:0005249; F:voltage-gated potassium channel activity; IBA:GO_Central.
DR   GO; GO:0071805; P:potassium ion transmembrane transport; IBA:GO_Central.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR003968; K_chnl_volt-dep_Kv.
DR   InterPro; IPR003972; K_chnl_volt-dep_Kv1.
DR   InterPro; IPR004053; K_chnl_volt-dep_Kv1.6.
DR   InterPro; IPR011333; SKP1/BTB/POZ.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR028325; VG_K_chnl.
DR   PANTHER; PTHR11537; PTHR11537; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   PRINTS; PR00169; KCHANNEL.
DR   PRINTS; PR01513; KV16CHANNEL.
DR   PRINTS; PR01491; KVCHANNEL.
DR   PRINTS; PR01496; SHAKERCHANEL.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000002281};
KW   Ion channel {ECO:0000256|SAAS:SAAS00417203};
KW   Ion transport {ECO:0000256|SAAS:SAAS00417186};
KW   Membrane {ECO:0000256|SAAS:SAAS00788393, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|SAAS:SAAS00417282};
KW   Potassium channel {ECO:0000256|SAAS:SAAS00417246};
KW   Potassium transport {ECO:0000256|SAAS:SAAS00417240};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00793138,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00789957,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|SAAS:SAAS00417268};
KW   Voltage-gated channel {ECO:0000256|SAAS:SAAS00091688}.
FT   TRANSMEM    176    196       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    263    280       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    377    398       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    438    459       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       41    141       BTB. {ECO:0000259|SMART:SM00225}.
SQ   SEQUENCE   530 AA;  58648 MW;  9C60BC01714ADCBB CRC64;
     MRSEKSLTLA APGEVRGPEG EQQDAGDFPE AGGGGGLCSS ERLVINISGL RFETQLRTLS
     LFPDTLLGDP GRRVRFFDPL RNEYFFDRNR PSFDAILYYY QSGGRLRRPV NVPLDIFLEE
     IRFYQLGDEA LAAFREDEGC LPEGGEDEKP LPSQPFQRQV WLLFEYPESS GPARGIAIVS
     VLVILISIVI FCLETLPQFR ADGRGGSNGG GVSRVSPVSR GSQEEEEEED DSYAFHPGIT
     PGGMVPGGSS SLSTFGGSFF TDPFFLVETL CIVWFTFELL VRFSACPSKP AFFRNIMNII
     DLVAIFPYFI TLGTELVQQQ EQQSASGGGG QNGQQAMSLA ILRVIRLVRV FRIFKLSRHS
     KGLQILGKTL QASMRELGLL IFFLFIGVIL FSSAVYFAEA DDDDSLFPSI PDAFWWAVVT
     MTTVGYGDMY PMTVGGKIVG SLCAIAGVLT IALPVPVIVS NFNYFYHRET EQEEQGQYTH
     VTCGQPTPDL KAADNGLGKP EFSEGPRERR PSYLPTPHRV YAEKRMLTEV
//
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