ID F7E0Y9_HORSE Unreviewed; 251 AA.
AC F7E0Y9;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 13-SEP-2023, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=Oxidoreductase HTATIP2 {ECO:0000256|ARBA:ARBA00039778};
GN Name=HTATIP2 {ECO:0000313|Ensembl:ENSECAP00000017666.3};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017666.3, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000017666.3, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017666.3,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000017666.3}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017666.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000256|ARBA:ARBA00004259}.
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DR AlphaFoldDB; F7E0Y9; -.
DR Ensembl; ENSECAT00000021450.4; ENSECAP00000017666.3; ENSECAG00000050787.1.
DR GeneTree; ENSGT00390000008184; -.
DR HOGENOM; CLU_071330_2_2_1; -.
DR OrthoDB; 150138at2759; -.
DR TreeFam; TF312849; -.
DR Proteomes; UP000002281; Chromosome 7.
DR Bgee; ENSECAG00000021124; Expressed in zone of skin and 23 other cell types or tissues.
DR ExpressionAtlas; F7E0Y9; baseline.
DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR CDD; cd05250; CC3_like_SDR_a; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR000534; Semialdehyde_DH_NAD-bd.
DR PANTHER; PTHR14097; OXIDOREDUCTASE HTATIP2; 1.
DR PANTHER; PTHR14097:SF7; OXIDOREDUCTASE HTATIP2; 1.
DR Pfam; PF13460; NAD_binding_10; 1.
DR SMART; SM00859; Semialdhyde_dh; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281}.
FT DOMAIN 29..130
FT /note="Semialdehyde dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|SMART:SM00859"
SQ SEQUENCE 251 AA; 27805 MW; 5996B39E7F88EAE8 CRC64;
MGELSPCSEM AETEALPKLR EDFRMQNKSV FILGASGETG RVLLKEILEQ SLFSKVTLIG
RRKLTFDEDA YKNVNQEVVD FEKLEDYASA FEGHDVGFCC LGTTRSKAGA EGFVRVDRDY
VLKSAELAKA GGCKHFNLLS SKGADKSSNF LYLQVKGEVE ARVEELKFDR YSIFRPGVLL
CDRQESRPGE WLVRKFFGSL PESWAGGHSV PVVTVVRAML NNAVRLGDGT TELLDNKAIH
DLGKADGSLK P
//
