ID F7E1R0_HORSE Unreviewed; 1180 AA.
AC F7E1R0;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 10-APR-2019, sequence version 2.
DT 24-JAN-2024, entry version 64.
DE SubName: Full=Fibronectin type III domain containing 3B {ECO:0000313|Ensembl:ENSECAP00000017358.2};
GN Name=FNDC3B {ECO:0000313|Ensembl:ENSECAP00000017358.2,
GN ECO:0000313|VGNC:VGNC:18088};
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796 {ECO:0000313|Ensembl:ENSECAP00000017358.2, ECO:0000313|Proteomes:UP000002281};
RN [1] {ECO:0000313|Ensembl:ENSECAP00000017358.2, ECO:0000313|Proteomes:UP000002281}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017358.2,
RC ECO:0000313|Proteomes:UP000002281};
RX PubMed=19892987; DOI=10.1126/science.1178158;
RG Broad Institute Genome Sequencing Platform;
RG Broad Institute Whole Genome Assembly Team;
RA Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
RA Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H., Distl O.,
RA Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N., Penedo M.C.T.,
RA Raison J.M., Sharpe T., Vogel J., Andersson L., Antczak D.F., Biagi T.,
RA Binns M.M., Chowdhary B.P., Coleman S.J., Della Valle G., Fryc S.,
RA Guerin G., Hasegawa T., Hill E.W., Jurka J., Kiialainen A., Lindgren G.,
RA Liu J., Magnani E., Mickelson J.R., Murray J., Nergadze S.G., Onofrio R.,
RA Pedroni S., Piras M.F., Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A.,
RA Searle S., Skow L., Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J.,
RA Vaudin M., White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
RT "Genome sequence, comparative analysis, and population genetics of the
RT domestic horse.";
RL Science 326:865-867(2009).
RN [2] {ECO:0000313|Ensembl:ENSECAP00000017358.2}
RP IDENTIFICATION.
RC STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000017358.2};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; F7E1R0; -.
DR Ensembl; ENSECAT00000021094.3; ENSECAP00000017358.2; ENSECAG00000019423.4.
DR VGNC; VGNC:18088; FNDC3B.
DR GeneTree; ENSGT00940000157005; -.
DR HOGENOM; CLU_004152_0_0_1; -.
DR TreeFam; TF316401; -.
DR Proteomes; UP000002281; Chromosome 19.
DR Bgee; ENSECAG00000019423; Expressed in articular cartilage of joint and 23 other cell types or tissues.
DR ExpressionAtlas; F7E1R0; baseline.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 9.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF19; FIBRONECTIN TYPE III DOMAIN-CONTAINING PROTEIN 3B; 1.
DR Pfam; PF00041; fn3; 8.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 5.
DR PROSITE; PS50853; FN3; 9.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000002281};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1155..1178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 254..353
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 357..449
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 453..546
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 550..645
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 649..741
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 742..835
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 847..933
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 934..1028
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1032..1129
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..179
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1180 AA; 130034 MW; BB27D6DD1A69B8B3 CRC64;
MNVRHHDDDR PDPSGTATTA ERRGSHDAPL GEWRCRSAGP AEVPMMSPNG SIPPIHVPPG
YISQVIEDNT GVRRVVVTPQ SPECYPPSYP SAMSPTHHLP PYLTHHPHFI HNSHTAYYPP
VTGPGDMPPQ FFPQHHLPPT IYGEQEIIPL YGMSSYITRE DQYSKPPHKK LKDRQIDRQN
RLNSPPSSIY KSSCTTVYNG YGKGHGGGGG GGGSGGGPGI KKTERRARSS PKSNDSDLQE
YELEVKRVQD ILSGIEKPQV SNIQARAVVL SWAPPVGLSC GPHSGLSFPY SYEVALSDKG
RDGKYKIIYS GEELECNLKD LRPATDYHVR VYAMYNSVKG SCSEPVSFTT HSCAPECPFP
PKLAHRSKSS LTLQWKAPID NGSKITNYLL EWDEGKRNSG FRQCFFGSQK HCKLTKLCPA
MGYTFRLAAR NDIGTSGYSQ EVVCYTLGNI PQMPSAPRLV RAGVTWVTLQ WNKPEGCSPE
EVVTYTLEIQ EDENDNLFHP KYTGEDLTYT VKNLKRSTQY KFRLTASNME GKSCPSEVLV
CTTSPDRPGP PTRPLIKGPV TSHGFSVKWD PPKDNGGSEI LKYLLEITDG NSEASQWEVA
YSGSATEYTL THLKPGTLYK LRACCISTGG HSQCSESLPV RTLSIAPGQC RPPRVLGRPK
HKEVHLEWDV PASESGCEVS EYSVEMTEPE DVASEVYHGP ELECTVGNLL PGTVYRFRVR
ALNDGGYGPY SDVSEITTAA GPPGQCKAPC ISFTPDGCVL VSWESPESAG ADISEYRLEW
GEDEESLELV YHGADTGFEM RDLLPAAQYC CRLQAVNQAG AGPYSELVLC QTPASAPDPV
STLCVLEEET LNAYPDSPSL CLVLNWEEPC NNGSEILAYN IDLGDTSITV GNTTSHIMKD
LLPETTYRIR IQAINEIGAG PFSQFIKAKT RPLPPLPPRL ECAAAGPQSL KLKWGDSNAK
AHAADDMVYT LQLEDRNKRF ISIYRGPSHT YKVQRLTEFT CYSFRIQAAS EAGEGPFSET
YTFSTTKSVP PAIKAPRVTQ LEGNSCEILW ETVPPMKGDP VSYILQVLVG RESEYKQVYK
GEEATFQISG LQTNTDYRFR VCACRRCLDT SQELSGAFSP SAAFVLQRSE VMLPGDMGSL
DDPKTKSMMP TDEQFAALIV VGFATLSIFF AFILQYFLMK
//