GenomeNet

Database: UniProt
Entry: F7E1Z0_ORNAN
LinkDB: F7E1Z0_ORNAN
Original site: F7E1Z0_ORNAN 
ID   F7E1Z0_ORNAN            Unreviewed;       408 AA.
AC   F7E1Z0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 3.
DT   24-JAN-2024, entry version 75.
DE   SubName: Full=Napsin A aspartic peptidase {ECO:0000313|Ensembl:ENSOANP00000019807.4};
GN   Name=NAPSA {ECO:0000313|Ensembl:ENSOANP00000019807.4};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000019807.4, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000019807.4, ECO:0000313|Proteomes:UP000002279}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000019807.4,
RC   ECO:0000313|Proteomes:UP000002279};
RX   PubMed=18464734; DOI=10.1038/nature06936;
RA   Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA   Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA   Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA   Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA   Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA   Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA   Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA   Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA   Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA   Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA   Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA   Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA   Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA   Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA   Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA   Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA   Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA   Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA   de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT   "Genome analysis of the platypus reveals unique signatures of evolution.";
RL   Nature 453:175-183(2008).
RN   [2] {ECO:0000313|Ensembl:ENSOANP00000019807.4}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000019807.4};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; F7E1Z0; -.
DR   STRING; 9258.ENSOANP00000019807; -.
DR   MEROPS; A01.046; -.
DR   Ensembl; ENSOANT00000019810.4; ENSOANP00000019807.4; ENSOANG00000012522.4.
DR   eggNOG; KOG1339; Eukaryota.
DR   GeneTree; ENSGT00940000160179; -.
DR   HOGENOM; CLU_013253_3_3_1; -.
DR   InParanoid; F7E1Z0; -.
DR   OMA; DYVIQIS; -.
DR   OrthoDB; 1120702at2759; -.
DR   TreeFam; TF314990; -.
DR   Proteomes; UP000002279; Chromosome 10.
DR   Bgee; ENSOANG00000012522; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR   GO; GO:0097208; C:alveolar lamellar body; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IBA:GO_Central.
DR   GO; GO:0033619; P:membrane protein proteolysis; IEA:Ensembl.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   GO; GO:0043129; P:surfactant homeostasis; IEA:Ensembl.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF51; NAPSIN-A; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..408
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5028212272"
FT   DOMAIN          80..397
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   REGION          47..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        98
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        285
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        111..118
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        276..280
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   408 AA;  44108 MW;  7871BAE029FD9F62 CRC64;
     MLRLRLLLLL LSAPLAGPAL LRIPLRRGRS VHRTLDALGD VSREWTALEA PDPPGPTSGN
     PQPHNEPVLE PLTNYLDAQY FGEIGLGTPP QHFSVVFDTG SSNLWVPSRH CSFFNLACWL
     HRRYDSSASS SFHPNGSHFA IRYGTGRLDG FLSQETLTIG KLQGKAVPFG EAVHQPGLVF
     ILAHFDGILG LGYPALAAAG AQPVFDALLE QGLLDAPIFS FYFNRDPTGE EGGELVLGGT
     DPAHYTGELH FLNVTRKAYW QIQMDEVAVG PQLTLCKGGC QAIVDTGTSL ITGPSPEIRA
     LQRAIGALPV FGGEYMVPCE TLPSLPVVSF QLGGVWFNLT AEQYVLKITR LGTGVCLSGF
     LGLDIPPPAG PLWILGDVFL GPHYTVFDRQ RDRVGLARAQ ARSRRGGP
//
DBGET integrated database retrieval system