ID F7E281_XENTR Unreviewed; 593 AA.
AC F7E281;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Transporter {ECO:0000256|RuleBase:RU003732};
GN Name=lmbrd1 {ECO:0000313|Ensembl:ENSXETP00000025716};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000025716};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000025716}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000025716};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000025716}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) (TC
CC 2.A.22) family. {ECO:0000256|RuleBase:RU003732}.
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DR AlphaFoldDB; F7E281; -.
DR PaxDb; 8364-ENSXETP00000007843; -.
DR Ensembl; ENSXETT00000025716; ENSXETP00000025716; ENSXETG00000011753.
DR AGR; Xenbase:XB-GENE-1015707; -.
DR Xenbase; XB-GENE-1015707; lmbrd1.
DR Bgee; ENSXETG00000011753; Expressed in mesonephros and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005332; F:gamma-aminobutyric acid:sodium:chloride symporter activity; IEA:InterPro.
DR GO; GO:0006836; P:neurotransmitter transport; IEA:InterPro.
DR InterPro; IPR000175; Na/ntran_symport.
DR InterPro; IPR002980; Na/ntran_symport_GABA_GAT1.
DR InterPro; IPR037272; SNS_sf.
DR NCBIfam; NF037979; Na_transp; 1.
DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1.
DR PANTHER; PTHR11616:SF316; TRANSPORTER; 1.
DR Pfam; PF00209; SNF; 1.
DR PRINTS; PR01195; GAT1TRNSPORT.
DR PRINTS; PR00176; NANEUSMPORT.
DR SUPFAM; SSF161070; SNF-like; 1.
DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1.
DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1.
DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Symport {ECO:0000256|RuleBase:RU003732};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003732};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003732}.
FT TRANSMEM 50..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 207..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 318..342
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..406
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 418..437
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 449..474
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 495..514
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..554
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 593 AA; 67298 MW; 68EC67416C1BD6DB CRC64;
MGKIDCDSVE LTSPNDEHHA LPGETLYLPF GQKKKKADDD RGTWKGKFDF LLSCVGYAIG
LGNVWRFPYL CGKNGGGAFL IPYFLTLVFA GIPLFFLETA LGQFTSIGGL GVWKLAPMFK
GVGMAAVVLS FWLNIYYIVI IAWALYYLFN SFSSTLPWQS CDNSWNTERC FSNYSLNDTS
NLTSAVTEFW ERNMHQMTGG LGEPGNIRWP LACTLALAWI MVYFSIWKGV EWTGKVVYFS
ATYPYFMLVI LFFRGITLPG AMDGIRFYIT PDFSKLANSE VWMDAATQIF FSYGLGLGSL
IALGSYNAFD NNIYRDSIIV CGINSTTSMF AGFVIFSIVG FMSHITKKPI QELAASGPGL
AFLAYPQAVT QLPMSPVWSI LFFSMLVMLG LDSQFCTVEG FITALVDEYP QCLRSRKKVF
IAMVCFISFI IGFSNITQGG LYVFKLFDYY SASGMCLLFL VFFETVSISW CYGVDRFYQD
IEEMIGYQPC SWWKLCWAYF TPCICLGVFC FSVFEMTPLT LGRYVYPAWG QGIGWLMALS
SMVFIPGYML YLLLTTKGTL RQVRTLVHQW LQRMRLLYKD IKILLRYRDL YTL
//
