ID F7E305_MACMU Unreviewed; 2017 AA.
AC F7E305;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 91.
DE SubName: Full=Myosin X {ECO:0000313|Ensembl:ENSMMUP00000016643.4};
GN Name=MYO10 {ECO:0000313|Ensembl:ENSMMUP00000016643.4,
GN ECO:0000313|VGNC:VGNC:75108};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000016643.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000016643.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000016643.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cell cortex
CC {ECO:0000256|ARBA:ARBA00004544}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR SMR; F7E305; -.
DR Ensembl; ENSMMUT00000017771.4; ENSMMUP00000016643.4; ENSMMUG00000012672.4.
DR VEuPathDB; HostDB:ENSMMUG00000012672; -.
DR VGNC; VGNC:75108; MYO10.
DR GeneTree; ENSGT00940000155469; -.
DR TreeFam; TF316834; -.
DR Proteomes; UP000006718; Chromosome 6.
DR Bgee; ENSMMUG00000012672; Expressed in fibroblast and 21 other cell types or tissues.
DR ExpressionAtlas; F7E305; baseline.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13202; FERM_C_MyoX; 1.
DR CDD; cd17206; FERM_F1_Myosin-X; 1.
DR CDD; cd14873; MYSc_Myo10; 1.
DR CDD; cd13297; PH3_MyoX-like; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 6.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR031971; MYO10_CC.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR041797; MyoX_FERM_C.
DR InterPro; IPR040640; MyoX_N_SH3.
DR InterPro; IPR036124; MYSc_Myo10.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR PANTHER; PTHR46049; AGAP003327-PA; 1.
DR PANTHER; PTHR46049:SF2; UNCONVENTIONAL MYOSIN-X; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00612; IQ; 3.
DR Pfam; PF16735; MYO10_CC; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF18597; SH3_19; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 1.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50200; RA; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|PROSITE-ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 56..725
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1198..1343
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1351..1456
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1506..1654
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 1659..2003
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT DOMAIN 1663..1712
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 605..627
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 805..852
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 950..1078
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1017
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 150..157
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 2017 AA; 232613 MW; 6738A3FA1EB37D1C CRC64;
MDFGISRKNG QHFPSTVNSC AEGVVVFRTD YGQVFTYKQS TITHQKVTAM HPTNEEGVDD
MASLTELHGG SIMYNLFQRY KRNQIYTYIG SILASVNPYQ PIAGLYEHAT MEQYSRRHLG
ELPPHIFAIA NECYRCLWKR HDNQCILISG ESGAGKTEST KLILKFLSVI SQQSLELSLK
EKTSCVERAI LESSPIMEAF GNAKTVYNNN SSRFGKFVQL NICQKGNIQG GRINRVVRQN
PGERNYHIFY ALLAGLEHEE REEFYLSTPE NYHYLNQSGC VEDKTISDQE SFREVITAMD
VMQFSKEEVR EVSRLLAGIL HLGNIEFITA GGAQVSFKTA LGRSAELLGL DPTQLTDALT
QRSMFLRGEE ILTPLNVQQA VDSRDSLAMA LYACCFEWVI KKINSRIKGK EDFKSIGILD
IFGFENFEVN HFEQFNINYA NEKLQEYFNK HIFSLEQLEY SREGLVWEDI DWIDNGECLD
LIEKKLGLLA LINEESHFPQ ATDSTLLEKL HSQHANNHFY VKPRVAVNNF GVKHYAGEVQ
YDVRGILEKN RDTFRDDLLN LLRESRFDFI YDLFEHVSSR NNQDTLKCGS KHRRPTVSSQ
FKDSLHSLMA TLSSSNPFFV RCIKPNMQKM PDQFDQAVVL NQLRYSGMLE TVRIRKAGYA
VRRPFQDFYK RYKVLMRNLA LPEDVRGKCT SLLQLYDASN SEWQLGKTKV FLRESLEQKL
EKRREEEVSH AAMVIRAHVL GFLARKQYRK VLYCVVIIQK NYRAFLLRRR FLHLKKAAIV
FQKQLRGQIA RRVYRQLLAE KREQEEKKKQ EEEEKKKREE EERERERQRR EAELRAQQEE
ETRKQQELEA LQKSQKEAEL TRELEKQKEN KQVEEILRLE KEIEDLQRMK EQQELSLTEA
SLQKLQQRRD QELRRLEEEA CRAAQEFLES LNFDEIDECV RNIERSLSVG SEFSSELAES
ACEEKPNFNF SQPYPEEEVD EGFEADDDAF KDSPNPSEHG HSDQRTSGIR TSDDSSEEDP
YMNDTVVPTS PSADSTVLLT PSVQDSGSLH NSSSGESTYC MPQNAGDLPS PDGDYDYDQD
DYEDGAITSG SSVTFSNSYG SQWSPDYRCS MGTYNSSGAY RFSSEGAQSS FEDSEEDFDS
RFDTDDELSY RRDSVYSCVT LPYFHSFLYM KGGLMNSWKR RWCVLKDETF LWFRSKQEAL
KQGWLHKKGG GSSTLSRRNW KKRWFVLRQS KLMYFENDSE EKLKGTVEVR TANRCPDNSW
FSVLSQVHAS TDQEIQEMHD EQANPQNAVG TLDVGLIDSV CASDSPDRPN SFVIITANRV
LHCNADTPEE MHHWITLLQR SKGDTRVEGQ EFIVRGWLHK EVKNSPKMSS LKLKKRWFVL
THNSLDYYKS SEKNALKLGT LVLNSLCSVV PPDEKIFKET GYWNVTVYGR KHCYRLYTKL
LNEATRWSSA IQNVTDTKAP IDTPTQQLIQ DIKENCLNSD VVEQIYKRNP ILRYTHHPLH
SPLLPLPYGD INLNLLKDKG YTTLQDEAIK IFNSLQQLES MSDPIPIIQG ILQTGHDLRP
LRDELYCQLI KQTNKVPHPG SVGNLYSWQI LTCLSCTFLP SRGILKYLKF HLKRIREQFP
GTEMEKYALF TYESLKKTKC REFVPSRDEI EALIHRQEMT STVYCHGGGS CKITINSHTT
AGEVVEKLIR GLAMEDSRNM FALFEYNGHV DKAIESRTVV ADVLAKFEKL AATSEVGDLP
WKFYFKLYCF LDTDNVPKDS VEFAFMFEQA HEAVIHGHHP APEENLQVLA ALRLQYLQGD
YTLHAAIPPL EEVYSLQRLK ARISQSTKTF TPCERLEKRR TSFLEGTLRR SFRTGSVVRQ
KVEEEQMLDM WIKEEVSSAR ASIIDKWKKF QGMNQEQAMA KYMALIKEWP GYGSTLFDVE
CKEGGFPQEL WLGVSADAVS VYKRGEGRPL EVFQYEHILS FGAPLANTYK IVVDERELLF
ETSEVVDVAK LMKAYISMIV KKRYSTTRSA SSQGSSR
//
