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Database: UniProt
Entry: F7E4C0_XENTR
LinkDB: F7E4C0_XENTR
Original site: F7E4C0_XENTR 
ID   F7E4C0_XENTR            Unreviewed;      4950 AA.
AC   F7E4C0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   22-NOV-2017, entry version 47.
DE   SubName: Full=Ryanodine receptor 1 (skeletal) {ECO:0000313|Ensembl:ENSXETP00000006174};
GN   Name=ryr1 {ECO:0000313|Ensembl:ENSXETP00000006174};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
OC   Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000006174, ECO:0000313|Proteomes:UP000008143};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000006174}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000006174};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L.,
RA   Blitz I.L., Blumberg B., Dichmann D.S., Dubchak I., Amaya E.,
RA   Detter J.C., Fletcher R., Gerhard D.S., Goodstein D., Graves T.,
RA   Grigoriev I.V., Grimwood J., Kawashima T., Lindquist E., Lucas S.M.,
RA   Mead P.E., Mitros T., Ogino H., Ohta Y., Poliakov A.V., Pollet N.,
RA   Robert J., Salamov A., Sater A.K., Schmutz J., Terry A., Vize P.D.,
RA   Warren W.C., Wells D., Wills A., Wilson R.K., Zimmerman L.B.,
RA   Zorn A.M., Grainger R., Grammer T., Khokha M.K., Richardson P.M.,
RA   Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000006174}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSXETP00000006174}.
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DR   EMBL; AAMC01090208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAMC01090209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   IntAct; F7E4C0; 2.
DR   STRING; 8364.ENSXETP00000006174; -.
DR   PaxDb; F7E4C0; -.
DR   Ensembl; ENSXETT00000006174; ENSXETP00000006174; ENSXETG00000002823.
DR   Xenbase; XB-GENE-1013509; ryr1.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; F7E4C0; -.
DR   OMA; DIPARRN; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Reactome; R-XTR-2672351; Stimuli-sensing channels.
DR   Reactome; R-XTR-5578775; Ion homeostasis.
DR   Proteomes; UP000008143; Unassembled WGS sequence.
DR   Bgee; ENSXETG00000002823; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008143};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4239   4259       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4482   4502       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4556   4577       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4690   4714       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4752   4772       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4831   4854       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       86    141       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      148    193       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      201    256       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      262    319       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      327    384       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      576    786       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1003   1199       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1336   1549       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4950 AA;  562648 MW;  36B8CADA9E0F9347 CRC64;
     QFMQEDVVVL QCSATIRKEQ IKMCMGAEGF GNRLCFLEST SNAQNVPPDL AICCFILEQS
     LSVRALQEML ANTVEMGNES SQGGGHRTLL YGHAILLRHC HSDMYLCCLT TSRSLTDKLA
     FDVGLQEDST GEACWWTIHP ASKQRSEGEK VRVGDDLILV SVSSERYLHL STASGELQVD
     ASFMQTLWNM NPITSGCELA EGYVTGGHVL RLFHGHMDEC LTIASTDQGE EQRRIPHYEG
     GAVCSHARSL WRLEPLRISW SGSHMKWGQS FRVRHVTTGR YLARDDEKGL VVLDAERANT
     KATAFCFRAS KEKLDVAPKR DVEGMGIAEI KYGESMCFVQ HVSSGLWLTY GALDAKVVRL
     GPLKRKAILH QEGHMDDALC LSRSQREESQ ASRMIYSTSG LFNLFIKGLD SLSGKNKPSK
     PVTLPIDMVI LTLQDLIGYF QHPEDELQHE EKQTKLRSLK NRQNLFQEEG IISLVLDCID
     RLNVYSTAAH FSEFAGEEAA ESWKEIVNLL YELLAALIRG NRSNCALFSS NLDWVVSKLD
     RLEASSGILE VLYCVLIESP EVLNIIKENH IKSIISLLDK HGRNHKVLDV LCSLCVCNGV
     AVRSNQNLIT ENLLPRRDLL LQTRLVNYVT SMRPNVFLGT CEGSTQYKKW YYEMVVDHVE
     PFVTAEATHL RVGWAMTEGY SPYPGAGEGW GANGVGDDLY SFGFDGLHLW SGRVCRPVTS
     HNQHLLAADD VVSCCLDLTV PSISFRFNGH PVQGMFENFN LDGLFFPVVS FSAGINIRFL
     LGGRHGDFKF LPPPGYAPVY EALLPRDRMR IEPIKEYKHD FENIRNLLGP TKSLSHTSFV
     PCPVDTVQIV LPPHLERIRE KLAENIHELW ALTRIEQGWT YGTVVRDDNK RLHPCLLDFH
     NLPEPERNYN LQMSGETLKT LLALGCHVGM ADEKAEENLK KIKLPKTYVM SNGYKPAPLD
     LSHVKLTPAQ NTLVDKLAEN GHNVWARDRV LQGWTYSIIQ DIKNKRNPRL VPYSLLDEKT
     KKTNRDSLCE AVRTLIGYGY NIEPPDQEST AQGIIKARAE RMRIFRAEKS YAVKSGKWYF
     EFEAVTTGEM RVGWVRPEVR PDVELGADEL AYVFNGCRGQ RWHIGSEPFG RNWLPGDVVG
     CMIDLTEMNI MFTLNGEMLI SDSGSELAFK DIEIGDGFIP VCSLGMSQVG RLNLGQDVSS
     LRYFTICGLQ EGFEPFAINM KRDITTWFSK SLPQFVNVPT DHAHIEVGRI DGTVDNPPCL
     KVTHKTFGSQ NSNNDMQFFR LSMPVEFHET FKCTPGATPL TRTLTIPEDD VQEVDMDSEF
     EMLKKAVSRK EAEATNEKET AKEPPKEQIK PENEKDTASE KVKTKRGFLF KARKPAFISP
     PPVVPTMPRL MKDVVPDDRD DPEIIMNTTT YYYSVRIFAG QEPTGVWIGW VTPDYHLYDM
     NFDLSKVRVA TITMGDDKGN IFNSIKRSNC YMVWGGEFGN NTQQARVRKE DLVIGCLIDL
     ATGLMTFTAN GKEVNTFFQV EPNTKLFPAV FASPQSQNMF QFELGKLKNI MPISAAMFRS
     ENKNPVPQCP PRLEVQMLTP VVWSRMPNDF LNVESERISE RQGWMVECSE PLMMMALHIP
     EESRCIDVLE LSERLNMLKF HYHTLKLYCS VCALGNNRVA HALCSHVDES QLLYTIESNH
     LSGLLRSGYY DLLISIHLES EKRARLTMNN EFIVPMTEET KSITLFPNDN KKHGLPGVGM
     STCLKPDLHF SHTCFVSTST ELYQLSPFIP LDVLKIKAIN MLTEAVLDGG QHTRDPVGGS
     VEFQFVPVLK LISTLLIMGV FEDDDVRHIL KMIEPNVFNE PESGLLQMKL PESVKLQMCN
     LLQYFCDREL QHRVEAIIAF SERHMESLQT NQRQRYKELM QAFTMTAAET ARRTREFRSP
     PQEQINMLLN FRNLSEDDCP IPEDIRDELS EFHTDLLSHC GVQMEGEEEE EHEDTSLHKR
     LLNLVEKLKH FRKKEEPEPE PEEKEEPKPS TLQELISHTM VHWAQESFIQ SPELVRVMFS
     LLHRQYDGLG ELIRALPKAY TINAVSVEDT MNLLESLGQI RSLLIVQMGP EEENLMIQSI
     GNIMNNKVFY QHPNLMRALG MHETVMEVMV NVLGGGDSKE IRFPKMVTNC CRFLCYFCRI
     SRQNQRAMFD HLSYLLQNSG IGLGMRGSTP LDVAAASVID NNELALALQE QDLEKVVSYL
     AGCGLQSCPM LLSKGYPDIG WNPVGGERYL DFLRFAVFVN GESVEENANV VVRLLIRRPE
     CFGPALRGEG GNGLLAAIEE AIKISEDPAR DGPTVKKDRR RELYGGEEVH EENRVHLGNA
     IMSFYSALID LLGRCAPEMH LIQAGKGEAL RIRAILRSLV PIEDLVGVIS LPLQIPAFGK
     DGNPIEPKMS ASFVPDHKAP MVLFLDRVYG IENQDFLLQV LEVGFLPDMR AAASLDTAAF
     STTEMALALN RYLCLAVLPL ITKCAPLFAG TEHRAIMVDS MLHTIYRLSR GRSLTKAQRD
     VIEECLMALC RYLRPSMLQH LLRRLVFDVP ILNEYAKMPL KLLTNHYERC WKYYCLPTGW
     ANYGVTSEEE LHLTRKLFWG IFESLAHKRF DAELYKIAMP CLCAIAGAIP PDYVDASYSS
     KTEKKASVDA EGNFDPKPIE TLNVIIPEKL DGFINKYAEY THDKWAFEKI QNNWSYGEAV
     DEEAKTHPML RPYKTFSEKD KEIYRWPIKE SLKAMIAWEW TVEKAREGED DKIEKKTKSR
     KISQSAQQTY DPTVQTFSPT PMDLTGITLS RELQSMAEQL AENYHNTWGR KKKQELESKG
     GGTHPLLVPY DTLTAKEKAR DREKAQELLK FLQINGYAVT RGLKDMELDT SSIEKRFAYG
     FLQKLLKLMD TAQEFIAHLE AVVSSGRVEK SPHEREIKFF AKILLPLINQ YFKNHCLYFL
     STPAKVLGSG GHASNKEKEM IASLFCKMAA LVRHRVSLFG TDAPAVVNCL HILARSLDAR
     TVMKSGPEIV KAGLRSFFEG ASEDIEKMVE NLKLGKVSQS RTQVKGVAQN INYTTVALLP
     VLTSLFEHIA QHQFGDDVIL DDVQVSCYRT LCSIYSLGTT KSPYVEKQRP ALGECLARLA
     AAMPVAFLEP SLNEYNIYSV YTTKSPRERA ILGLPNSVEE MCPDIPDLET LMKDISMLAE
     SGARYTEMPH VIEVTLPMLC NYLPRWWERG PENIPDDSSP CCTSVTSEHL NTLLGNILRI
     VVNNLGIDEA SWMKRLAVFA QPIVSKAKPE LLRSHFIPTM EKLKKRAGKV VAEEEQLRME
     AKSESEDSES LIRDEFSVLC RDLYALYPLL IRYVDNNRAH WLTEPNLDAE ELFRMVGEVF
     IFWSKSHNFK REEQNFVVQN EINNMSFLTA DSKSKMSKSG DSQSGGSDQE RTKKKRRGDR
     YSVQTSLIVA TLKKMLPIGL NMCSPTDQEL ITLAKTRYSL KDTDEEVREF LQNNLHLQGK
     CDNSSMRWQM ALYNKMSGKA EDSNNPEKIV KRVQEVSAVL FHLELTEHPF KSKKAVWHKL
     LSKQRRRAVV ACFRMTPLYN LPRHRACNMF LEGYKQAWIM SEAHDFEDRM IDDLSNFKYL
     HYIDSNESKE PDPLHQLILH FSRTALTEKS KLDEDYLYMA YADIMAKSCH MEDESEEAAE
     DEEEVELTFE EKEMEKQKLL YQQSRLHNRG AAEMVLQMIS ACKGEPGSMV SSTLKLGISI
     LNGGNSDVQQ KMLDYLKEKR EVGFFQSVQA LMQTCSVLDL NAFERQNKAE GLGMVTEDGT
     IINREQGEKV MADDQFTQDL FRLLQLLCEG HNNDFQNYLR TQTGNTTTIN IIICTVDYLL
     RLQESISDFY WYYSGKDIID DQGKRNFSKA MSVAKQVFNS LTEYIQGPCT GNQQSLAHSR
     LWDAVVGFLH VFAHMMMKLA QDSSQIGLLK ELLDLQKDMV VMLLSLLEGN IVNGTIARQM
     VDMLVESSSN VEMILKFFDM FLKLKDIVAS DAFRDYVTDP RGLISKKDFQ KAMDSQKQYT
     TSEIQFLLSC SEADENEMIN FEEFADRFQE PAKDIGFNLA VLLTNLSEHV PNDTRLQNFL
     ELADCIINYF KPYLGKIEIM GAGKRIERIY FEISEANKTQ WEMPQVKESK RQFIFDVVNE
     GGESEKMELF VNFCEDTIFE MQIASQISEP EEEKAEDDED DVVEGSGEGE EAENGSSPQE
     ASSAFGEFLN NVMNFFKMFT YKNLRRQYRK VKKMSFKEII LAIVSFLWTV FLGILHFVYS
     VCKGIFLLIW HTLFGGSLVE GAQKLTVTEL LASMPDPTQD EVHSDGPAVA VSDEEPEAGD
     VTDFVDISKE EVQEEGTDIF GIDLKKEGGH YRASAPDAPG GLGDMGDTTP VEPPTPEGSP
     ILKRKLADEE TSGEEHDVVP EEEPAPEPEP EKADLENGEK TAEVQEETAP EPEEPEQPEV
     APKKKSPARD KKPEAEEGGF EFWNELEIQR IKFLNYLSRN FYNLRFLALF LAFAINFILL
     FYKVSDSPLG EDDFEGSGIE DEISGMDDGG GDEDEEEEGP VYFVLEESTG YMQPTLYMLS
     VIHTLIAFLC IIGYNCLKIP LVIFKREKEL ARKLEFDGLY ITEQPEDDDI KGQWDRLVLN
     TPSFPSNYWD KFVKRKVLDK YGDIYGRERI AELLGMDLAS LEISSQNGKK QEPDKSLLSW
     FTSIDIKYQI WNFGVVFTDN SFLYLVWYMV MSLLGHYNNF FYAAHLLDIA MGVKTLRTIL
     SSVTHNGKQL MMTVGLLAVV VYLYTVVAFN FFRKFYNKSE DEDEPDMKCD DMMTCYLFHM
     YVGVRAGGGI GDEIEDPAGD EYELYRVVFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ
     EQVKEDMETK CFICGIGSDY FDTTPHGFEN HTLEEHNLAN YMFFLMYLIN KDDTEHTGQE
     SYVWKMYQER CWDFFPAGDC FRKTYEDQLG
//
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