ID F7EA05_ORNAN Unreviewed; 1467 AA.
AC F7EA05;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Kielin cysteine rich BMP regulator {ECO:0000313|Ensembl:ENSOANP00000023034.3};
GN Name=KCP {ECO:0000313|Ensembl:ENSOANP00000023034.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000023034.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000023034.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000023034.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000023034.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000023034.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSOANT00000023038.3; ENSOANP00000023034.3; ENSOANG00000014620.4.
DR eggNOG; KOG1216; Eukaryota.
DR GeneTree; ENSGT00940000160243; -.
DR HOGENOM; CLU_018024_2_0_1; -.
DR InParanoid; F7EA05; -.
DR OMA; CQECVVE; -.
DR TreeFam; TF343473; -.
DR Proteomes; UP000002279; Chromosome 10.
DR Bgee; ENSOANG00000014620; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IBA:GO_Central.
DR CDD; cd19941; TIL; 1.
DR Gene3D; 6.20.200.20; -; 10.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR46698; CROSSVEINLESS 2; 1.
DR PANTHER; PTHR46698:SF2; KIELIN_CHORDIN-LIKE PROTEIN; 1.
DR Pfam; PF00093; VWC; 8.
DR Pfam; PF00094; VWD; 1.
DR SMART; SM00832; C8; 1.
DR SMART; SM00214; VWC; 16.
DR SMART; SM00215; VWC_out; 8.
DR SMART; SM00216; VWD; 1.
DR SUPFAM; SSF57603; FnI-like domain; 15.
DR SUPFAM; SSF57567; Serine protease inhibitors; 1.
DR PROSITE; PS01208; VWFC_1; 5.
DR PROSITE; PS50184; VWFC_2; 11.
DR PROSITE; PS51233; VWFD; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 72..165
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 213..271
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 328..385
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 385..444
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 509..568
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 672..731
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 787..849
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 849..907
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 907..975
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 993..1035
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1039..1099
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 1103..1274
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 33..67
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1467 AA; 157523 MW; 2A718EA29506A22F CRC64;
GPLGPPGLTD AQHYQQQEPA DPHGPAGPDP ERLRRLEERL EGLRAAVALL KEQNAVLQSR
VKQLESCECR RPLCTWQGKQ HPDGTRWEPD ACTSCLCLDG AVRCRAHPDR PRCLGNPSLS
NQSVGKGALS PSLQDGTVQC QGPLCPELMC LEHYTPSGDC CPVCHSGPPN PSPLPDSPSQ
WLEGQVLCHQ KECASLCPHP ARPHPGTCCP VCDGCFLNGH EYRSGESVKS GDPCTHCRCE
DGRVHCEPVP CPSLPCSHPG KRPSQCCPVC EGCEYEGHQY QSEETFQPPG HGPCTHCSCQ
TGTVQCEEEQ CPPAPCFHPV SHPQHCLCML DGEEFAEGVE WEPEGQPCHT CSCVRGLPVC
GPVLCPPPTY PSTPPCPGAC CPKCQSCTFR HRVYANGQNF TDPDSPCQTC HCQDGTVQCS
PIDCPPTTCA RPQTVPGQCC PKCPDCLLEK QVFVDGESFS SPRDPCQECQ CRGGSVHCQS
RACPEAPCAH PLPGTCCQSN FPRGCDAWGG CDFAGKEYPN GAEFPHPTDR CRLCHCINGN
VQCLRRRCPP LSCPEPFLPP GDCCPQCPAP PAGCPRPGSP PARHQEQFSP PRDPCRRCLC
LNGSTSCQRL PCAPVPCTHP LQGACCPSCD GSPRRGAGSG QGVGLPLCWR AVRVCAGRAA
WRPLGWSLVI PSGCEYLGES YLSGQEFPEP GEPCSHCTCL GGFVSCSRRP CYQPGCSHPV
TPPGQCCPLC QGCLYSGITA ATGETFPDPA DPSCSLCTCQ AGSVQCLRKL CPPATCPHPT
PGPCSCPICL GCRFEGQERQ DGEVFEGPEG SCEQCRCQAG SVHCEKDPCP HLSCALQVTE
PGTCCPRCRG CVSQGSQHPE GSSWTPPDAP CSTCMCHEGV VTCARIRCIS SCARPRQVPG
ECCPLCEDCV HEGRTYHPGD SFQPGADPCE LCTCELQPEG SPRLHCSRKQ CPSLLGCPPS
QLLPPGPRDC CPTCAQALSN CTAGLLGRRL PAPDPCYTCQ CQDLTWLCVP RACPQLSCPL
AQHHTPPGAC CPVCDAPTLP CSYQGRKVPS GEKWAVDECT SCSCLSGVVQ CRSQRCPPLT
CAPEEAPGLH PGHCCPRCLA RPASCLAFGD PHYRTFDGRL LHFQGSCSYV LARDCRGGDF
SVHVTNEDRG RRGVAWTRAV TVLLGGLDVR LLRHGDVTVD GRPVSLPFLR EPLLFVELRG
RTVLLHTQLG LKVLWNGQSQ VEVSVPGSYR GRTCGLCGNF NGFAQDELRG PTGLPLASEA
TFGNSWQFSR GWEGLWGSSS RLCASSCSPG QEVNPCREAG YRARREANAR CAVLKSVAFE
RCHPVVPPEP FFAACVYDLC ACGPGAPADA CLCDVLEAYA TRCRQAGISP KWRGPSLCAV
GCPLDRGFVF DECGPPCPRT CFNQHVPLRE LAAHCVRPCV PSCQCPAGLV EHEGHCILPK
FCPPIQLAPE LEPMPLPTPS RDPRWRS
//
