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Database: UniProt
Entry: F7EB11_XENTR
LinkDB: F7EB11_XENTR
Original site: F7EB11_XENTR 
ID   F7EB11_XENTR            Unreviewed;       686 AA.
AC   F7EB11; A0A6I8SZ55;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-JUN-2021, sequence version 4.
DT   24-JAN-2024, entry version 69.
DE   SubName: Full=Protein-glutamine gamma-glutamyltransferase 4 {ECO:0000313|RefSeq:XP_002937794.2};
DE   SubName: Full=Transglutaminase 4 {ECO:0000313|Ensembl:ENSXETP00000018585};
GN   Name=tgm4 {ECO:0000313|Ensembl:ENSXETP00000018585,
GN   ECO:0000313|RefSeq:XP_002937794.2,
GN   ECO:0000313|Xenbase:XB-GENE-1012962};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000018585};
RN   [1] {ECO:0000313|Ensembl:ENSXETP00000018585}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000018585};
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
RN   [2] {ECO:0000313|Ensembl:ENSXETP00000018585}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUN-2011) to UniProtKB.
RN   [3] {ECO:0000313|RefSeq:XP_002937794.2}
RP   IDENTIFICATION.
RC   STRAIN=Nigerian {ECO:0000313|RefSeq:XP_002937794.2};
RC   TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_002937794.2};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000459-2};
CC       Note=Binds 1 Ca(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR000459-2};
CC   -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC       Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR   RefSeq; XP_002937794.2; XM_002937748.5.
DR   PaxDb; 8364-ENSXETP00000024621; -.
DR   Ensembl; ENSXETT00000018585; ENSXETP00000018585; ENSXETG00000008494.
DR   Ensembl; ENSXETT00000073790; ENSXETP00000100798; ENSXETG00000008494.
DR   GeneID; 100488625; -.
DR   KEGG; xtr:100488625; -.
DR   CTD; 7047; -.
DR   Xenbase; XB-GENE-1012962; tgm4.
DR   eggNOG; ENOG502QQ46; Eukaryota.
DR   HOGENOM; CLU_013435_0_2_1; -.
DR   OMA; NKEFTCA; -.
DR   TreeFam; TF324278; -.
DR   Proteomes; UP000008143; Chromosome 6.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR002931; Transglutaminase-like.
DR   InterPro; IPR036985; Transglutaminase-like_sf.
DR   InterPro; IPR023608; Transglutaminase_animal.
DR   InterPro; IPR013808; Transglutaminase_AS.
DR   InterPro; IPR008958; Transglutaminase_C.
DR   InterPro; IPR036238; Transglutaminase_C_sf.
DR   InterPro; IPR001102; Transglutaminase_N.
DR   PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR   PANTHER; PTHR11590:SF70; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE 4; 1.
DR   Pfam; PF00927; Transglut_C; 1.
DR   Pfam; PF01841; Transglut_core; 1.
DR   Pfam; PF00868; Transglut_N; 1.
DR   PIRSF; PIRSF000459; TGM_EBP42; 1.
DR   SMART; SM00460; TGc; 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF81296; E set domains; 1.
DR   SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
DR   PROSITE; PS00547; TRANSGLUTAMINASES; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000459-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT   DOMAIN          256..349
FT                   /note="Transglutaminase-like"
FT                   /evidence="ECO:0000259|SMART:SM00460"
FT   ACT_SITE        264
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT   ACT_SITE        323
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT   ACT_SITE        346
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-1"
FT   BINDING         386
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT   BINDING         388
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT   BINDING         438
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
FT   BINDING         443
FT                   /ligand="Ca(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29108"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000459-2"
SQ   SEQUENCE   686 AA;  76434 MW;  BAD96A4EB1F4F320 CRC64;
     MALKTEKVDF LKTENTSQHN TNDYDNPNLI LRRGQEFHMK ITFDRELTAN DKVTLQFTTG
     SLALPSNGTL VLIDVGPVIQ TNQWSALIRQ RNNKEYLVAV SSPATAIVGK YMLSIITGKG
     IVYPLADCTI YLLCNPWCKD DTVYMPSEDG RKEYVLKDTG YIYVGIATKI TAKPWNFGQY
     EAEVLDCCMF LLDHGQLKPE HRRDPVILTR KLSALVNSND DRGVLTGNWS GNYSGGFSPT
     SWTGSSVILQ KYYKSKRSVM YGQCWVFSGI LTTVLRCLGI PARSVTNFNS AHDTGGNLKV
     DVYLNEKGEI LEDLCSDSVW NFHVWNDAWM KRPDLPKGYD GWQAVDATPQ ELSQGVYECG
     PCSLAAVKNG DVYLPYDGKF VFAEINADRI CWLVKDKQGD EPPIQIRQEK SCIGECISTK
     TVNMNVREDI TVQYKHPEGS PEERETFQKA CSFLNSGACL VSPEPPPYPP AGTKLQIQGD
     KELIPGNPLS FTVSIENETN EAKSLDITIG CQLQAYTGKV IASVASIKQS VQVPGKKVAY
     IPVTVASEQY MKSVIMVEDE AIFRINAITE NKETQEKTSD SMAIAFTYPP IKVEMPETAK
     INEDFSCTFT FKNTLSIQLD KCQLHVEGLS MFKLETFDEG DIKPGGIFRS KIICAPRRPG
     EKKIVAKLIS SQIKGISVEK TIIIIN
//
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