ID F7EBK3_MACMU Unreviewed; 5550 AA.
AC F7EBK3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Midasin {ECO:0000256|ARBA:ARBA00017143, ECO:0000256|PIRNR:PIRNR010340};
GN Name=MDN1 {ECO:0000313|Ensembl:ENSMMUP00000004615.4,
GN ECO:0000313|VGNC:VGNC:74530};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000004615.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000004615.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000004615.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Nuclear chaperone required for maturation and nuclear export
CC of pre-60S ribosome subunits. {ECO:0000256|PIRNR:PIRNR010340}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC {ECO:0000256|ARBA:ARBA00004604}. Nucleus, nucleoplasm
CC {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the midasin family.
CC {ECO:0000256|ARBA:ARBA00007188, ECO:0000256|PIRNR:PIRNR010340}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSMMUT00000004900.4; ENSMMUP00000004615.4; ENSMMUG00000003464.4.
DR VEuPathDB; HostDB:ENSMMUG00000003464; -.
DR VGNC; VGNC:74530; MDN1.
DR eggNOG; KOG1808; Eukaryota.
DR GeneTree; ENSGT00550000074802; -.
DR HOGENOM; CLU_041241_0_0_1; -.
DR Proteomes; UP000006718; Chromosome 4.
DR Bgee; ENSMMUG00000003464; Expressed in Ammon's horn and 22 other cell types or tissues.
DR ExpressionAtlas; F7EBK3; baseline.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd01460; vWA_midasin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 7.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR040848; AAA_lid_7.
DR InterPro; IPR011704; ATPase_dyneun-rel_AAA.
DR InterPro; IPR048617; MDN1_AAA_lid_4.
DR InterPro; IPR012099; Midasin.
DR InterPro; IPR041190; Midasin_AAA_lid_5.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF07728; AAA_5; 8.
DR Pfam; PF17865; AAA_lid_5; 1.
DR Pfam; PF17867; AAA_lid_7; 3.
DR Pfam; PF21108; MDN1_4th; 1.
DR PIRSF; PIRSF010340; Midasin; 3.
DR SMART; SM00382; AAA; 6.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 6.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR010340};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|PIRNR:PIRNR010340};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR010340};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR010340};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718}.
FT DOMAIN 5338..5537
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 4651..5214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4651..4694
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4709..4729
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4730..4765
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4771..4791
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4803..4847
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4861..4886
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4896..4910
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4917..4948
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5030..5045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5055..5081
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5149..5164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5182..5214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 5550 AA; 627638 MW; E7C6EBBB5F0D887F CRC64;
MEHFLLEVAA APLRLIAAKN EKSRSELGRF LAKQVWTYQD RQCVLSTLAQ LLLDKDCTVL
VGRHLRPLLL DLLERNAEAI KAGGQINHDL HERLCVSMSK LIGNHPDVLP FALRYFKDTS
PVFQRLFLES SDANPVRYGR RRMKLRDLME AAYKFLQQEQ SVFRELWDWS VCVPLLRSHD
TLVRWYTANC LALVTCMNEE HKLSFLKKIF NSDELIHFRL RLLEEAQLQD LEKALVLANP
EASLWCKEKE LQYLQGHLVS SDLSPRVTAV CGVVLPGQPP ATGELGGNRS SSREQELALR
SYVLVESVCK NLETLAMAVA SQNAVLLEGP IGCGKTSLVE YLAAMTGRTK PPQLLKVQLG
DQTDSKMLLG MYRCTDVPGE FVWQPGTLTQ AATMGHWILL EDIDYAPLDV VSVLIPLLEN
GDLLIPGQGD CLKVAPGFQF FATRRLLSCG GNWYRPLNSH ATLLDKYWTK IHLDNLDKRE
LNEVLQSRYP SLLAVVDHLL EIYIQLTGEK HHSWSDRSVG CEQAPEEVSE ARRENKRPTL
EGRELSLRDL LNWCNRIAHS FDSSSLSASL NIFQEALDCF TAMLSEHTSK LKMAEVIGSK
LNISRKKAEF FCQLYKPEIV INELDLQVGR VRLLRKQSEA VHMQREKFTF AATRPSSVLI
EQLAVCVSKG EPVLLVGETG TGKTSTVQYL AHITGHRLRV VNMNQQSDTA DLLGGYKPVD
HKLIWLPLRE AFEELFAQTF SKKQNFTFLG HIQTCYRQKR WHDLLRLMQH VHKSAVNKDG
KESETGLLIK EKWEAFGLRL NHAQQQMKMT ENTLLFAFVE GTLAQAVKKG EWILLDEINL
AAPEILECLS GLLEGSSGSL VLLDRGDTEP LVRHPDFRLF ACMNPATDVG KRNLPPGIRN
RFTELYVEEL ESKEDLQVLI VDYLKGLSVN KNTVQGIINF YTALRKESGT KLVDGTGHRP
HYSLRTLCRA LRFAASNPCG NIQRSLYEGF CLGFLTQLDR ASHPIVQKLI CQHIVSGNVK
SLLKQPIPEP KGGRLIQVEG YWIAVGDKEP TIDETYILTS SVKLNLRDIV RVVSAGTYPV
LIQGETSVGK TSLIQWLAAA TGNHCVRINN HEHTDIQEYI GCYTSDSSGK LVFKEGVLID
AMRKGYWIIL DELNLAPTDV LEALNRLLDD NRELLVTETQ EVVKAHPRFM LFATQNPPGL
YGGRKVLSRA FRNRFVELHF DELPSSELET ILHKRCSLPP SYCSKLVKVM LDLQSYRRSS
SVFAGKQGFI TLRDLFRWAE RYRLAEPTEK EYDWLQHLAN DGYMLLAGRV RKQEEVDVIQ
EVLEKHFKKK LCPQSLFSKE NVVKLLGKLS TQISTLESNF GHIVWTEGMR RLAMLVGRAL
EFGEPVLLVG DTGCGKTTIC QVFAALANQK LYSVSCHLHM ETSDFLGGLR PVRQKPKDKE
EIDTSRLFEW HDGPLVQAMK EDGFFLLDEI SLADDSVLER LNSVLEVEKS LVLAEKGSPE
DKDSEVELLT AGKKFRILAT MNPGGDFGKK ELSPALRNRF TEIWCPQSTS REDLIQIINH
NLRPGLCLGR IDPKGSDIPE VMLDFIDWLT HQEFGRKCVV SIRDILSWVN FMNKMGEEAA
SKRPETISTV TSFVHAACLV YIDGIGSGVT SSGFGTALLA RKECLKFLIK RLAKIVRLTE
YQKNELKIYD RMKAKEFTGI DNLWGIHPFF IPRGPVLHRN NIADYALSAG TTAMNAQRLL
RATKLKKPIL LEGSPGVGKT SLVGALAKAS GNTLVRINLS EQTDITDLFG ADLPVEGGKG
GEFAWRDGPL LAALKAGHWV VLDELNLASQ SVLEGLNACF DHRGEIYVPE LGMSFQVQHE
KTKIFGCQNP FRQGGGRKGL PRSFLNRFTQ VFVDPLTVID MEFIASTLFP AIEKNIVKKM
VAFNNQIDHE VTVEKKWGQK GGPWEFNLRD LFRWCQLMLV DQSPGCYDPG QHVFLVYGER
MRTEEDKKKV IAVFKDVFGS NSNPYMGTRL FRITPYDVQL GYSVLSRGSC VPHPSRHPLL
LLHQSFQPLE SIMKCVQMSW MVILVGPASV GKTSLVQLLA HLTGHTLKIM AMNSAMDTTE
LLGGFEQVDL IRPWRQLLEK VEATVRALLR DSLLISADDA EVVLRAWSHF LLTYKPKCLG
EGGKAITMEI VNKLEAVLLL MQRLNNKINS YSKAEFAKLV EEFRSFGVKL TQSASGRSHG
TFEWVDSMLV QALKSGDWLL MDNVNFCNPS VLDRLNALLE PGGVLTISER GMIDGSTPTI
TPNPNFRLFL SMDPVHGDIS RAMRNRGLEI YISGEGDVST PDNLDLKVLL HSLGLVGNSV
CDILLALHTQ TRSTVVGSPT SSVSTLIRTA ILIVQYLQRG LSLDRAFSEA CWEVYVCSQH
SPANRKLVQA LLEKHVSSLR AHETWGDSIL GMGLWPDSVP SALFATEDSH LSTVRSDGQI
LAYCLNRMSM KTSSWTRSQP LTLQDLEKIM QSSSPENLKF NAVEVNTYWI DEPDVLAMAV
KLLIERATNQ DWMLRVKWLY HLAKNIPQGL ESIQIHLEAS AASLRNFYSH SLSGAVSNVF
KILQPNTTDE FVIPLDPRWN MQALDMIRNL MDFDPQTDQP DQLFALLESA ANKTIIYLDR
EKRVFTEANL VSVGSKKLRD SVLRMSFEFH QDPESYHTLP HEIVVNLAAF FELCDALVLL
WVQSSQGMVS DAIVYEILGS LRWRDRFWTV ADTVKVDAPG LALLALHWHW VLKHLVHQIP
QLLTNYEDKY YKEVQTVSEH IHNCLGSQTG GFVGVKKLQK FLGRPFPFKD KLVVECFSQL
KVLNKVLAIR EQMPALGENG WQEDLNRLQV VASQWTLKKS LLQAWGLILR ANILEDVNLD
ELKNFVHAHC LELKAKGLSL GFLEKKHGEA SSLSHPDLTS VIHLTRSVQL WPAMEYLAML
WQYKVTADFM AQASLRRCSK NQQPQINEEI SHLISFCLYH TPVAPQELRD LWSLLHHQKV
SPEEITSLWS ELFNSMFMSF WNSTVTTNPE YWLMWNPLPG MQQREAPKSA LDSTLKGPGN
LNRPIFSKCC FEVLTSSWRA SPWDVSGLPI LSSSHVTLGE WVERTQQLQD ISSMLWTNMA
ISSVAEFRRT DSQLQGQVLF RHLAGLVELL PESRRQEYMQ NCEQLLLGSS QAFQHVGQTL
GDLAGQEALP KELICQLLTS LHHLFGEGES KRSLPEPAQR GSLWVSLGLL QIQTWLPQAR
FDPAVKREYK LNYAKEELHQ LQCEWKTRNL SSQLQTGRDL EDEVVVSYSH PHVRLLRQRM
DRLDNLTCHL LKKQAFRPQL PAYESLVQEI HHYVTSIAKA PAVQDLLTRL LQALHMDGPR
SAQVAHSLLK EEASWQQSHH QFRKRLAEEY TFYPDAVSPL QASILQLQHG MRLVAYELHT
SLYSSMVGAD RLGTLATALL AFPSVGPTFP TYYAHADTLC SVKSEEVLRG LGKLIIKCSG
GKELEGKGQK ACPTREQLLM NALLYLRSHV LCKGELDQRA LQLFRHVCQE IINEWDEQER
IAQEKAEQES SLYRYRSRNS RTTLSEEEEE EREFRKQFPL HEKDFADILV QPTLEENKGT
SDGQEEEAAT NPALLSQNSM QAVMLIHQQL CLNFARSLWY QQTLPPHEAK HYLSLFLSCY
QTGASLVTHF YPLMGVELND RLLGSQLLAC TLSHNTLFGE VPSDLMVKPD GPYDFYQHPN
VPEARQCQPV LQGFSEAVSH LLRDWPEHPA LEQLLVVVDR IRSFPLSSPI SKFLNGLEIL
LAKAQDWEEN ASRTLSLRKH LDLISQMIIR WRKLELNCWS MSLDNTMKRH TEKSTKHWFS
IYQMLEKHMQ EQTEEQEDSL CSVLWNLYHY YKQFFDRVQA KIVELRSPLE KELKEFVKIS
RWNDVSFWSI KQSVEKTHRT LFKFMKKFEA VLSEPCRSSL VESDKEQQPD FLPRPTDGAA
VEASSIQNLN RALRETLLAR PAAGQATIPE CCQGAAPSAF EGELLRRLPK LRKRMRKMCL
TFMKESPLPR LVEGLDQFTG EVISSVSELQ SLKVEPSAEK EKQRSEAKHI LMQKQRALSD
LFKHLAKIGL SYRKGLAWAR SKNPQEMLHL HPLDLRSALS IVGSTQEADS RLLTEISSSW
DGCQKYFYRS LARHARLNAA LATPAKEMGM GNVERCRGFS AHLMKMLVQQ RRSLTTLSEQ
WIILRNLLSC VQEIHSRLMG PLAYPVAFPP QDGVQQWTER LQHLAMQCQI LLEQLSWLLQ
CCPSVGPAPG HGNAQALGQP PAPCLEGPEL SKGQLCGVLP DLIPSNLSYP SPVPGSQLPS
GCRMRKQDQL WQQSTTRVTE MLKTIKTVKA DVDKIRQQSC ETLFHSWKDF EVCSSALSCL
SQVSVHLQGL ESLFILPGME VEQRDSQMAL VESLEYVRGE ISKAMADFTT WKTHLLTSGS
QGGNQMLDEG FVEDFSEKME IAIRAILCAI QNLEESKNEK AENTEDNTDQ ASPQEEYAGF
ERLQSGHLTK LLEDDFWADV STLNVQKIIS AISELLERLK SYGEDGTAAK HLFFSQSCSL
LVRLVPVLSS YSDLVLFFLT MSLATHRSTA KLLSVLAQVF TELAQKGFCL PKEFMEDSAG
EGATEFHDYE GGGIGEGEGM KDVSDQIENE EQVEDTFQKG QEKDKEDPDS KSDIKGEDNA
IEMSEDFDGK MHDGELEEQE EDDEKSDSEG GDLDKQMGDL NGEEADKLDE RLWGDDDEEE
DEEEEDNKTE ETGPGMDEED SELVAKDDNL DSGNSNKDKS QKDKKEEKEE SEADDGGEGE
DKINEQIDER EYDENEVDPY HGNQEKLPEP EALDLPDDLN LDSEDKNGGE DTDNEEGEEE
NPLEIKEKPE EAGHEAEERE TETDQNESQS PQEPEEGPSE DDKAKGEEEM DTGADDQDGD
AAQHPEEHSE EQQQSLEEKD KDADEEGGEN GPADQGFQPQ KQEEEQEDSD TEEQVPEVLE
RKEHASCGQT GVENMQSTQA VELAGAAPEK EQGKEEHGSG AADANQAEGH ESNFIAQLTS
QKHTRKNTQS FKRKPGQADN ERSMGDHNER VHKRLRTVDT DSHAEQGPAQ QPQAQVEDAD
AFEHIKQGSD AYDAQTYDVA SKEQQQSAKD SGRDQEEEEI EDTLMDTEEQ EELKAADVEQ
LKPEEIKSST TAPLGFDEME VEIQTVKTEE DQDPRTDRAH KETENEKPER SRESTIHTAH
QFLMDTIFQP FLKDVNELRQ ELERQLEMWQ PHESENPEEE KVAAEMWQSY LILTAPLSQR
LCEELRLILE PTQAAKLKGD YRTGKRLNIR KVIPYIASQF RKDKIWLRRT KPSKRQYQIC
LAIDDSSSMV DNHTKQLAFE SLAVIGNALT LLEVGQIAVC SFGESVKLLH PFHEQFSDYS
GSQILRLCKF QQKKTKIAQF LESVASMFAA AQQLSQNISP EIAQLLLVVS DGRGLFLEGK
ERVLAAVQAA RNANIFVIFV VLDNPSSRDS ILDIKVPIFK GPGEMPEIRS YMEEFPFPYY
IILRDVNALP ETLSDALRQW FELVTASDHP
//