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Database: UniProt
Entry: F7EDI7_CALJA
LinkDB: F7EDI7_CALJA
Original site: F7EDI7_CALJA 
ID   F7EDI7_CALJA            Unreviewed;      3566 AA.
AC   F7EDI7;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   27-JUL-2011, sequence version 1.
DT   25-OCT-2017, entry version 32.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSCJAP00000032421};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSCJAP00000032421};
OS   Callithrix jacchus (White-tufted-ear marmoset).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Platyrrhini; Cebidae; Callitrichinae; Callithrix; Callithrix.
OX   NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000032421, ECO:0000313|Proteomes:UP000008225};
RN   [1] {ECO:0000313|Ensembl:ENSCJAP00000032421, ECO:0000313|Proteomes:UP000008225}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCJAP00000032421}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSCJAP00000032421}.
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DR   EMBL; ACFV01027949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01027950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01027951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01027952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01027953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01027954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01027955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01027956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01027957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; ACFV01027958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSCJAT00000034266; ENSCJAP00000032421; ENSCJAG00000017504.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000008225; Chromosome 19.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000008225};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904}.
FT   DOMAIN        9     64       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN       71    116       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      124    181       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      187    241       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      255    312       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      498    708       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      924   1121       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1167   1378       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   3566 AA;  404116 MW;  93EAD21B6749B6B1 CRC64;
     MKTAQGGGHR TLLYGHAILL RHSYSGMYLC CLSTSRSSTD KLAFDVGLQE DATGEACWWT
     IHPASKQRSE GEKVRVGDDL ILVSVSSERY LHLSYGNGSL HVDAAFQQTL WSVAPISSGS
     EAAQGYLIGG DVLRLLHGHM DECLTVPSGE HGEEQRRNRT VHYEGGAVSV HARSLWRLET
     LRVAWSGSHI RWGQPFRLRH VTTGKYLSLM EDKNLLLMDK EKADVKSTAF TFRSSKMLKE
     KLDVGVRKEV DGMGTSEIKY GDSVCYIQHV DTGLWLTYQS VDVKSVRMGS IQRKAIMHHE
     GHMDDGINLS RSQHEESRTA RVIRSTVFLF NRFISCKKAK ASTVDLPIES VSLSLQDLIG
     YFHPPDEHLE HEDKQNRLRA LKNRQNLFQE EGMINLVLDC IDRLHVYSSA AHFADVAGRE
     AGESWKSILN SLYELLAALI RGNRKNCAQF SGSLDWLISR LERLEASSGI LEVLHCVLVE
     SPEALNIIKE GHIKSIISLL DKHGRNHKVL DVLCSLCVCH GVAVRSNQHL ICDNLLPGRD
     LLLQTRLVNH VSSMRPNIFL GVSEGSAQYK KWYYELMVDH TEPFVTAEAT HLRVGWASTE
     GYSPYPGGGE EWGGNGVGDD LFSYGFDGLH LWSGCIARTV SSPNQHLLRT DDVISCCLDL
     SAPSISFRIN GQPVQGMFEN FNIDGLFFPV VSFSAGIKVR FLLGGRHGEF KFLPPPGYAP
     CYEAVLPKEK LKVEHSREYK QERTYTRDLL GPTVSLTQAA FTPIPVDTHQ IVLPPHLERI
     REKLAENIHE LWVMNKIELG WQYGPVRDDN KRQHPCLVEF SKLPEQERNY NLQMSLETLK
     TLLALGCHVG ISDEHAEEKV KKMKLPKNYQ LTSGYKPAPM DLSFIKLTPS QEAMVDKLAE
     NAHNVWARDR IRQGWTYGIQ QDVKNRRNPR LVPYTLLDDR TKKSNKDSLR EAVRTLLGYG
     YNLEAPDQDH AARAEVCSGT GERFRIFRAE KTYAVKAGRW YFEFEAVTAG DMRVGWSRPG
     CQPDQELGSD ERAFAFDGFK AQRWHQGNEH YGRSWQAGDV VGCMVDMNEH TMMFTLNGEI
     LLDDSGSELA FKDFDVGDGF IPVCSLGVAQ VGRMNFGKDV STLKYFTICG LQEGYEPFAV
     NTNRDITMWL SKRLPQFLQV PSNHEHIEVT RIDGTIDSSP CLKVTQKSFG SQNSNTDIMF
     YRLSMPIECA EVFSNLLTCL KSELFQSELS LCQYLVLLSS QYYYSVRIFP GQEPANVWVG
     WITSDFHQYD TGFDLDRVRT VTVTLGDEKG KVHESIKRSN CYMVCAGESM SPGQGRNNNG
     LEIGCVVDAA SGLLTFIANG KELSTYYQVE PSTKLFPAVF AQATSPNVFQ FELGRIKNVM
     PLSAGLFKSE HKNPVPQCPP RLHVQFLSHV LWSRMPNQFL KVDVSRISER QGWLVQCLDP
     LQFMSLHIPE ENRSVDILEL TEQEELLKFH YHTLRLYSAV CALGNHRVAH ALCSHVDEPQ
     LLYAIENKYM PGLLRTGYYD LLIDIHLSSY ATARLMMNNE YIVPMTEETK SITLFPDENK
     KHGLPGIGLS TSLRPRMQFS SPSFVSISNE CYQYSPEFPL DILKAKTIQM LTEAVREGGL
     HARDPVGGTT EFLFVPLIKL FYTLLIMGIF HNEDLKHILQ LIEPSVFKEA ATLEEESDAL
     EKELHVEDAR LQGAGEEEAK GGKRPKEGLL QMKLPEPVKL QMCLLLQYLC DCQVRHRIEA
     IVAFSDDFVA KLQDNQRFRY NEVMQALNMS AALTARKTKE FRSPPQEQIN MLLNFKDDKS
     ECPCPEEIRD QLLDFHEDLM THCGIELDED GSLDGNSDLT IRGRLLSLVE KVTYLKKKQA
     EKPIESDSKK SSTLQQLISE TMVRWAQESV IEDPELVRAM FVLLHRQYDG IGGLVRALPK
     TYTINGVSVE DTINLLASLG QIRSLLSVRM GKEEEKLMIR GLGDIMNNKV FYQHPNLMRA
     LGMHETVMEV MVNVLGGGES KEITFPKMVA NCCRFLCYFC RISRQNQKAM FDHLSYLLEN
     SSVGLASPAM RGSTPLDVAA ASVMDNNELA LALREPDLEK VVRYLAGCGL QSCQMLVSKG
     YPDIGWNPVE GERYLDFLRF AVFCNGESVE ENANVVVRLL IRRPECFGPA LRGEGGNGLL
     AAMEEAIKIA EDPSRDGPSP NSGSSKTLDT EEEEDDTIHM GNAIMTFYAA LIDLLGRCAP
     EMHLIHAGKG EAIRIRSILR SLIPLGDLVG VISIAFQMPT IAKDGNVVEP DMSAGFCPDH
     KAAMVLFLDR VYGIEVQDFL LHLLEVGFLP DLRAAASLDT AALSATDMAL ALNRYLCTAV
     LPLLTRCAPL FAGTEHHASL IDSLLHTVYR LSKGCSLTKA QRDSIEVCLL SICGQLRPSM
     MQHLLRRLVF DVPLLNEHAK MPLKLLTNHY ERCWKYYCLP GGWGNFGAAS EEELHLSRKL
     FWGIFDALSQ KKYEQELFKL ALPCLSAVAG ALPPDYMESN YVSMMEKQSS MDSEGNFNPQ
     PVDTSNITIP EKLEYFINKY AEHSHDKWSM DKLANGWIYG EIYSDSSKVQ PLMKPYKLLS
     EKEKEIYRWP IKESLKTMLA WGWRIERTRE GDSMALYNRT RRISQTSQSN AAHGYSPRAI
     DMSNVTLSRD LHAMAEMMAE NYHNIWAKKK KMELESKGGG NHPLLVPYDT LTAKEKAKDR
     EKAQDILKFL QINGYAVSSC SRGFKDLELD TPSIEKRFAY SFLQQLIRYV DEAHQYILEF
     VCMLNRGKGE HFPYEQEIKF FAKVVLPLID QYFKNHRLYF LSAASRPLCS GGHASNKEKE
     MVTSLFCKLG VLVRHRISLF GNDATSIVNC LHILGQTLDA RTVMKTGLES VKSALRAFLD
     NAAEDLEKTM ENLKQGQFTH TRNQPKGVTQ IINYTTVALL PMLSSLFEHI GQHQFGEDLI
     LEDVQVSCYR ILTSLYALGT SKSIYVERQR SALGECLAAF AGAFPVAFLE THLDKHNIYS
     IYNTKSSRER AALSLPSNVE DVCPNIPSLE KLMEEIVELA ESGIRYTQIP HVMEVILPML
     CSYMSRWWEH GPENNPERAE MCCTALNSEH MNTLLGNILK IIYNNLGIDE GAWMKRLAVF
     SQPIINKVKP QLLKTHFLPL MEKLKKKAAM VVSEEDHLKA EARGDMSEAE LLILDEFTTL
     ARDLYAFYPL LIRFVDYNRA KWLKEPNPEA EELFRMVAEV FIYWSKSHNF KREEQNFVVQ
     NEINNMSFLI TDTKSKMSKN KMIKAAVSDQ ERKKMKRKGD RYSMQTSLIV AALKRLLPIG
     LNICAPGDQE LIALAKNRFS LKDTEDEVRD IIRSNIHLQG KLEDPAIRWQ MALYKDLPNR
     TDDASDPEKT VERVLDIANV LFHLEQVEHP QRSKKAVWHK LLSKQRKRAV VACFRMAPLY
     NLPRHRAVNL FLQGYEKSWI ETEEHYFEDK LIEDLAQKPG ADPPEEDECT KRVDPLHQLI
     LLFSRTALTE KCKLEEDFLY MAYADIMAKK SCRYQSCHDE EDNDGEEEVK SFEEKEMEKQ
     KLLYQQARLH DRGAAEMVLQ TISASK
//
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