ID F7EIG6_XENTR Unreviewed; 1065 AA.
AC F7EIG6;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 84.
DE SubName: Full=Rho guanine nucleotide exchange factor 1 {ECO:0000313|Ensembl:ENSXETP00000028760, ECO:0000313|RefSeq:XP_012822900.2};
GN Name=arhgef1 {ECO:0000313|Ensembl:ENSXETP00000028760,
GN ECO:0000313|RefSeq:XP_012822900.2,
GN ECO:0000313|Xenbase:XB-GENE-1009790};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000028760};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000028760}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000028760};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000028760}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_012822900.2}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_012822900.2};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_012822900.2};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004370}.
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DR RefSeq; XP_012822900.2; XM_012967446.3.
DR Ensembl; ENSXETT00000028760; ENSXETP00000028760; ENSXETG00000033428.
DR Xenbase; XB-GENE-1009790; arhgef1.
DR eggNOG; KOG3520; Eukaryota.
DR OMA; KPRCRRL; -.
DR TreeFam; TF106495; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Bgee; ENSXETG00000033428; Expressed in neurula embryo and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd14679; PH_p115RhoGEF; 1.
DR CDD; cd08755; RGS_p115RhoGEF; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR037887; p115RhoGEF_RGS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041020; PH_16.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR015212; RGS-like_dom.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR044926; RGS_subdomain_2.
DR PANTHER; PTHR45872:SF4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR PANTHER; PTHR45872; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 2, ISOFORM D; 1.
DR Pfam; PF17838; PH_16; 1.
DR Pfam; PF09128; RGS-like; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT DOMAIN 495..683
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 725..838
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 271..476
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 840..903
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 963..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1023..1050
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 271..312
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 367..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..879
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 978..995
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1065 AA; 120955 MW; C0FE05494DF2B2B1 CRC64;
MDPDDGHFGG LYSKGSMSII GAEDEDFEND IEPNMVDESS YFRSIELVKE HPAYIMVFLQ
HVVLQFDPSP LLCFLHAEML KNLSAKELKK VFMDFHYTFL MKGAVLHVSV PNSVSFELDR
TRPEMIPEET QRKYVKDIQK HQTEAISQQL EDFRAKRVLG MTPGELELSE LESYRTNDRS
ILEAKEKQLA EQLLARLDEM HLTIAPDEEK SSAIFCAIVA YMKHLGVKTK AADSKKSKGI
FFRKKVSTNK KDEPLKTKKT FSILDPMRWN RNDSHYVDSR PSKVEPEAEK PNPDRRVSQG
QRTFDRSDSS TAKSKNSEGP DSVVSVNIIP PPNEPNDPDP AVTDGALSND ASEVLKGSPT
TEHCPADQTE ESAENERRKK RLSGKLGRSE SLRVYERKRS QRGSSKAKQT RSRSDVDLEA
AARANDLQGT TGKLGPKPGN YTPEPGGSSE GPLPFLLPQS EETEPRVQEA ESDPPNWREL
VPPEILLRLK KSEIKRQEVI NELFFTEHAH VRMLRVLHDV FYIPMQNGWI PTLELENIFP
SLDDLIEAHA VFLDTLKRLR LENNSVIQEI GTILLNRFDG TEGNWFQKIS SRFCSRQPFA
LEQLKAKQKR DPRFTQFIQE AESSPHCRRL QLKDIIPFEM QRLTKYPLLL QNIANLTEED
EEKQRVQRAA ESCRQILNHV NQEVREMENK MKLTDYQRRL DVSNLRQIND PLFNEFKNID
ISKKNLIHEG SLTWKVSRDK AFDVHVLLLD DLLMLLLKQD ERLVLKCQSR TIIPAPDGKL
MLSPIIKLNM AMVREVATDK NAFFVIFNWE DRAQFYELVA PTPAEKKNWF LLISNTTGLL
EPPASSKQRH RSITPGTMPQ SPSDFADQLL SSSENGGSLK DSVSKDEKEE SVEDALEGQE
EKDFSGLTEY LLASNIDLNQ DAASGGGNVA SEALEEVSVL KRLLVRNIRL SVDADTLSTL
ETWSAGEEPA LEASEQGRAS NGDREAEDSE MESTQQGENG RKQSSADVSE SLCAPIVLSK
EQSEEVKRHI LSLEQRIQQL KLIEEDYNNL HRTIAKFTVP RSSFT
//
