ID   F7ES05_ORNAN            Unreviewed;       569 AA.
AC   F7ES05;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   02-DEC-2020, sequence version 2.
DT   27-MAR-2024, entry version 49.
DE   SubName: Full=Aminopeptidase like 1 {ECO:0000313|Ensembl:ENSOANP00000014753.2};
GN   Name=NPEPL1 {ECO:0000313|Ensembl:ENSOANP00000014753.2};
OS   Ornithorhynchus anatinus (Duckbill platypus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX   NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000014753.2, ECO:0000313|Proteomes:UP000002279};
RN   [1] {ECO:0000313|Ensembl:ENSOANP00000014753.2}
RP   IDENTIFICATION.
RC   STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000014753.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase M17 family.
CC       {ECO:0000256|ARBA:ARBA00009528}.
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DR   AlphaFoldDB; F7ES05; -.
DR   Ensembl; ENSOANT00000014756.3; ENSOANP00000014753.2; ENSOANG00000009270.4.
DR   GeneTree; ENSGT00530000063255; -.
DR   InParanoid; F7ES05; -.
DR   OMA; MVCEQSD; -.
DR   Proteomes; UP000002279; Unplaced.
DR   Bgee; ENSOANG00000009270; Expressed in endometrium and 8 other cell types or tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0030145; F:manganese ion binding; IEA:InterPro.
DR   GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IBA:GO_Central.
DR   GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR   CDD; cd00433; Peptidase_M17; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   Gene3D; 3.40.50.10590; Zn-dependent exopeptidases; 1.
DR   InterPro; IPR011356; Leucine_aapep/pepB.
DR   InterPro; IPR041417; NPEPL1_N.
DR   InterPro; IPR000819; Peptidase_M17_C.
DR   PANTHER; PTHR11963:SF4; AMINOPEPTIDASE NPEPL1-RELATED; 1.
DR   PANTHER; PTHR11963; LEUCINE AMINOPEPTIDASE-RELATED; 1.
DR   Pfam; PF18295; Pdase_M17_N2; 1.
DR   Pfam; PF00883; Peptidase_M17; 1.
DR   PRINTS; PR00481; LAMNOPPTDASE.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR   PROSITE; PS00631; CYTOSOL_AP; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000256|ARBA:ARBA00022438};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT   DOMAIN          386..393
FT                   /note="Cytosol aminopeptidase"
FT                   /evidence="ECO:0000259|PROSITE:PS00631"
FT   REGION          1..43
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   569 AA;  60650 MW;  255218987F71549F CRC64;
     MSEWPAARSS REKAGLRGRG RGGDGAGRGW GGPGEGRGGP GRRARKMANV LLHFQASAGE
     ADPQSRPLLL LGQLQNLHRV PWSHLRGKLQ PRVTEELWQA ALSTLNPNPT DSCPLYLNYA
     TVAALPSRVS RHNSPSAAQF ITRLVRNCLP GGANRCIMMV CERSEVFASA CALARAFPLF
     THRSSASRRT EKKTVTVEFF LVGQNNGPVE VSTLKCLASA TEGVRLAARI VDTPCNEMNT
     DNFIEEIKKV GKDLGIVPNI IRDEELKKRG FGGIYGVGKA ALHPPALAVL SHTPEGATQT
     IAWVGKGIVY DTGGLSIKGK TTMPGMKRDC GGAAAVLGAF KATVKQGFKD NLHAVFCLAE
     NSVGPNATRP DDIHELYSGK TVEINNTDAE GRLVLADGVA YACKDLGADI ILDMATLTGA
     QGIATGKYHA AVLTNSAEWE AACVKAGRNC GDLVHPLVYC PELHFSEFTS AVADMKNSVA
     DRDNTPSSCA GLFIASHIGF DWPGIWVHLD IASPVHAGER ATGYGVALLL SLFGQASDDP
     LLNLVSPLGG DVDSQGDDME RDSKRRRLV
//