GenomeNet

Database: UniProt
Entry: F7ETU0_MACMU
LinkDB: F7ETU0_MACMU
Original site: F7ETU0_MACMU 
ID   F7ETU0_MACMU            Unreviewed;      2478 AA.
AC   F7ETU0;
DT   27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT   30-NOV-2016, sequence version 2.
DT   27-SEP-2017, entry version 46.
DE   RecName: Full=Voltage-dependent P/Q-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1A {ECO:0000313|Ensembl:ENSMMUP00000004738};
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000004738, ECO:0000313|Proteomes:UP000006718};
RN   [1] {ECO:0000313|Ensembl:ENSMMUP00000004738, ECO:0000313|Proteomes:UP000006718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000004738,
RC   ECO:0000313|Proteomes:UP000006718};
RX   PubMed=17431167; DOI=10.1126/science.1139247;
RA   Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA   Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
RA   Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
RA   Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
RA   Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA   Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
RA   Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
RA   Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
RA   Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
RA   Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
RA   Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
RA   Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
RA   Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
RA   Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
RA   Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
RA   Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
RA   Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
RA   Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
RA   Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
RA   Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA   Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA   Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA   Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA   Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
RA   Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
RA   Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
RA   Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
RA   Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
RA   Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
RA   Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
RA   Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
RA   Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
RA   Zwieg A.S.;
RT   "Evolutionary and biomedical insights from the rhesus macaque
RT   genome.";
RL   Science 316:222-234(2007).
RN   [2] {ECO:0000313|Ensembl:ENSMMUP00000004738}
RP   IDENTIFICATION.
RC   STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000004738};
RG   Ensembl;
RL   Submitted (JUL-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1A
CC       gives rise to P and/or Q-type calcium currents. P/Q-type calcium
CC       channels belong to the 'high-voltage activated' (HVA) group and
CC       are blocked by the funnel toxin (Ftx) and by the omega-agatoxin-
CC       IVA (omega-Aga-IVA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-conotoxin-GVIA (omega-CTx-GVIA).
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMMUP00000004738}.
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DR   EMBL; JSUE03020853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03020854; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03020855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03020856; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03020857; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03020858; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03020859; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03020860; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03020861; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; JSUE03020862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9544.ENSMMUP00000004738; -.
DR   Ensembl; ENSMMUT00000005029; ENSMMUP00000004738; ENSMMUG00000003555.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; F7ETU0; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000006718; Chromosome 19.
DR   Bgee; ENSMMUG00000003555; -.
DR   ExpressionAtlas; F7ETU0; baseline.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0007628; P:adult walking behavior; IEA:Ensembl.
DR   GO; GO:0048266; P:behavioral response to pain; IEA:Ensembl.
DR   GO; GO:0048791; P:calcium ion-regulated exocytosis of neurotransmitter; IEA:Ensembl.
DR   GO; GO:0016049; P:cell growth; IEA:Ensembl.
DR   GO; GO:0030644; P:cellular chloride ion homeostasis; IEA:Ensembl.
DR   GO; GO:0021679; P:cerebellar molecular layer development; IEA:Ensembl.
DR   GO; GO:0021702; P:cerebellar Purkinje cell differentiation; IEA:Ensembl.
DR   GO; GO:0021590; P:cerebellum maturation; IEA:Ensembl.
DR   GO; GO:0048813; P:dendrite morphogenesis; IEA:Ensembl.
DR   GO; GO:0014051; P:gamma-aminobutyric acid secretion; IEA:Ensembl.
DR   GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0050883; P:musculoskeletal movement, spinal reflex action; IEA:Ensembl.
DR   GO; GO:0032353; P:negative regulation of hormone biosynthetic process; IEA:Ensembl.
DR   GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR   GO; GO:0050885; P:neuromuscular process controlling balance; IEA:Ensembl.
DR   GO; GO:0007274; P:neuromuscular synaptic transmission; IEA:Ensembl.
DR   GO; GO:0007270; P:neuron-neuron synaptic transmission; IEA:Ensembl.
DR   GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR   GO; GO:0043113; P:receptor clustering; IEA:Ensembl.
DR   GO; GO:0014056; P:regulation of acetylcholine secretion, neurotransmission; IEA:Ensembl.
DR   GO; GO:0050770; P:regulation of axonogenesis; IEA:Ensembl.
DR   GO; GO:0017158; P:regulation of calcium ion-dependent exocytosis; IEA:Ensembl.
DR   GO; GO:0031335; P:regulation of sulfur amino acid metabolic process; IEA:Ensembl.
DR   GO; GO:0060024; P:rhythmic synaptic transmission; IEA:Ensembl.
DR   GO; GO:0021522; P:spinal cord motor neuron differentiation; IEA:Ensembl.
DR   GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
DR   GO; GO:0035249; P:synaptic transmission, glutamatergic; IEA:Ensembl.
DR   GO; GO:0019226; P:transmission of nerve impulse; IEA:Ensembl.
DR   GO; GO:0021750; P:vestibular nucleus development; IEA:Ensembl.
DR   InterPro; IPR005448; CACNA1A.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF249; PTHR10037:SF249; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01632; PQVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000006718};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    129    149       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    161    181       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    216    235       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    294    315       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    327    349       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    465    484       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    496    516       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    591    613       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    667    691       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1223   1242       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1262   1283       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1295   1312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1357   1379       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1469   1494       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1550   1568       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1580   1603       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1671   1689       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1767   1791       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1928   1962       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
SQ   SEQUENCE   2478 AA;  278957 MW;  3B4702B55859601E CRC64;
     MARFGDEMPA RYGGGGSGAA AGVVVGAGGG RGAGGSRQGG QPGAQRMYKQ SMAQRARTMA
     LYNPIPVRQN CLTVNRSLFL FSEDNVVRKY AKKITEWPYP FARTPAAAQH LPDDDKTPMS
     ERLDDTEPYF IGIFCFEAGI KIIALGFAFH KGSYLRNGWN VMDFVVVLTG ILATVGTEFD
     LRTLRAVRVL RPLKLVSGIP SLQVVLKSIM KAMIPLLQIG LLLFFAILIF AIIGLEFYMG
     KFHTTCFEEG TDDIQGESPA PCGTEEPART CPNGTKCQPY WEGPNNGITQ FDNILFAVLT
     VFQCITMEGW TDLLYNSNDA SGNTWNWLYF IPLIIIGSFF MLNLVLGVLS GEFAKERERV
     ENRRAFLKLR RQQQIERELN GYMEWISKAG EALSSRALRR ATIKKSKTDL LNPEEAEDQL
     ADIASVGSPF ARASIKSAKL ENSTFFHKKE RRMRFYIRRM VKTQAFYWTV LSLVALNTLC
     VAIVHYNQPE WLSDFLYYAE FIFLGLFMSE MFIKMYGLGT RPYFHSSFNC FDCGVIIGSI
     FEVIWAVIKP GTSFGISVLR ALRLLRIFKV TKYWASLRNL VVSLLNSMKS IISLLFLLFL
     FIVVFALLGM QLFGGQFNFD EGTPPTNFDT FPAAIMTVFQ ILTGEDWNEV MYDGIKSQGG
     VQGGMVFSIY FIVLTLFGNY TLLNVFLAIA VDNLANAQEL TKVEGDEQEE EEAANQKLAL
     QKAKEVAEVS PLSAANMSIA MKEQQKNQKP AKSVWEQRTS EMRKQNLLAS REALYNEMDP
     DERWKAAYTR HLRPDMKTHL DRPLVVDPQE NRNNNTNKSR AAEPTVDQRL GQQRAEDFLR
     KQARYHDRAR DPSGSAGLDA RRPWAGSQEA ELSREGPYGR ESDHHAREGS LEQPGFWEGE
     AERGKAGDPH RRHVHRQGGS RESRSGSPRT GADGEPRRHR GHRRPGEEGP EDKAERRARH
     REGSRPARGG EGEGEGPDGG ERRRRHRHGA PATYEGDPRR EDKERRHRRR KENQGSGVPV
     SGPNLSTTRP IQQDLGRQDP PLAEDIDNMK NNKLATAESA GPHDSLGHAG LPQSPAKMGN
     STDPGPTPAI PAMATNPQNA ASRRMPNNPG NPSNPGPPKT PENSLIVTNP SGTQTNSAKT
     ARKPDHTTVD IPPACPPPLN HTVVQVNKNA NPDPLPKKED EKKEEEEDDR GEDGPKPMPP
     YSSMFILSTT NPLRRLCHYI LNLRYFEMCI LMVIAMSSIA LAAEDPVQPN APRNNVLRYF
     DYVFTGVFTF EMVIKMIDLG LVLHQGAYFR DLWNILDFIV VSGALVAFAF TGNSKGKDIN
     TIKSLRVLRV LRPLKTIKRL PKLKAVFDCV VNSLKNVFNI LIVYMLFMFI FAVVAVQLFK
     GKFFHCTDES KEFEKDCRGK YLLYEKNEVK ARDREWKKYE FHYDNVLWAL LTLFTVSTGE
     GWPQVLKHSV DATFENQGPS PGYRMEMSIF YVVYFVVFPF FFVNIFVALI IITFQEQGDK
     MMEEYSLEKN ERACIDFAIS AKPLTRHMPQ NKQSFQYRMW QFVVSPPFEY TIMAMIALNT
     IVLMMKFYGA SVAYENALRV FNIVFTSLFS LECVLKVMAF GILNYFRDAW NIFDFVTVLG
     SITDILVTEF GNNFINLSFL RLFRAARLIK LLRQGYTIRI LLWTFVQSFK ALPYVCLLIA
     MLFFIYAIIG MQVFGNIGID VEDEDSDEDE FQITEHNNFR TFFQALMLLF RSATGEAWHN
     IMLSCLSGKP CDKNSGILTR ECGNEFAYFY FVSFIFLCSF LMLNLFVAVI MDNFEYLTRD
     SSILGPHHLD EYVRVWAEYD PAAWGRMPYL DMYQMLRHMS PPLGLGKKCP ARVAYKRLLR
     MDLPVADDNT VHFNSTLMAL IRTALDIKIA KGGADKQQMD AELRKEMMAI WPNLSQKTLD
     LLVTPHKSTD LTVGKIYAAM MIMEYYRQSK AKKLQAMREE QDRTPLMFQR MEPPSPTQEG
     GPGQNALPSA QLDPGGALMA HESGLKESPS WVTQRAQEMF QKTGTWSPER GPPTDMPNSQ
     PNSQSVEMRE MGRDGYSDSE HYLPMEGQGR AASMPRLPAE NQRRRGRPRG NNLSTISDTS
     PMKRSASVLG PKARRLDDYS LERVPPEENQ RHHQRRRDRS HRTSERSLGR YTDVDTGLGT
     DLSMTTQSGD LPSKERDQER GRPKDRKHRQ HHHHHHHHHP PPPDKDRYAQ ERPDHGRARA
     RDQRWSRSPS EGREHMVHRQ GSSSVSGSPA PSTSGTSTPR RGRRQLPQTP STPRPHVSYS
     PVIRKAGGSG PPQQQQQAVA RPGRAATSGP RRYPGPTAEP LAGDRPPTGG HSSGRSPRME
     RRVPGPARSE SPRACRHGGA RWPASGPHVS EGPPGPRHHG YYRGSDYDEA DGPGSGGGGE
     AMAGAYDPPP PARHASSGAT GRSPRTPRAS GPACASPSRH GRRLPNGYYP AHGLARPRGP
     GSRKGLHEPY SESDDDWC
//
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