ID F7EV10_XENTR Unreviewed; 2698 AA.
AC F7EV10;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-JUN-2021, sequence version 4.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN Name=itpr2 {ECO:0000313|Ensembl:ENSXETP00000035890,
GN ECO:0000313|RefSeq:XP_031754313.1,
GN ECO:0000313|Xenbase:XB-GENE-877157};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000035890};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000035890}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000035890};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000035890}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUN-2011) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_031754313.1}
RP IDENTIFICATION.
RC STRAIN=Nigerian {ECO:0000313|RefSeq:XP_031754313.1};
RC TISSUE=Liver and blood {ECO:0000313|RefSeq:XP_031754313.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368044}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR RefSeq; XP_031754313.1; XM_031898453.1.
DR Ensembl; ENSXETT00000035890; ENSXETP00000035890; ENSXETG00000016448.
DR AGR; Xenbase:XB-GENE-5831784; -.
DR AGR; Xenbase:XB-GENE-877157; -.
DR Xenbase; XB-GENE-877157; itpr2.
DR eggNOG; KOG3533; Eukaryota.
DR HOGENOM; CLU_000206_1_0_1; -.
DR OrthoDB; 22856at2759; -.
DR TreeFam; TF312815; -.
DR Proteomes; UP000008143; Chromosome 3.
DR Bgee; ENSXETG00000016448; Expressed in neurula embryo and 13 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR45816:SF3; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU368044}; Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000008143};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368044};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368044};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT TRANSMEM 2226..2248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2260..2280
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2292..2315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2344..2372
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2393..2415
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2519..2542
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT DOMAIN 112..166
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 231..287
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT COILED 2629..2677
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2698 AA; 307414 MW; 38009BB1036A7D70 CRC64;
MPDKMSSFLY IGDIVSLYAE GSVNGFISTL GLVDDRCVVH PDAGDLANPP KKFRDCLFKV
CPMNRYSAQK QFWKAKQAKQ GNNTEAALLK KLQHAAELEQ KQNESENRKL LGEIVKYSNV
IQLLHIKSNK YLTVNKRLPA LLEKNAMRVS LDCAGNEGSW FYIQPFWKLR SEGDNVVVGD
KVVLMPVNAG QPLHASNIEL LDNPGCKEVN AVNCNTSWKV NLFMKFSDYR DDVLKGGDVV
RLFHAEQEKF LTCDEYEKKQ HIFLRTTLRQ SATSATSSKA LWEVEVVHHD PCRGGAGQWN
SLFRFKHLAT GNYLAAEINP DYRDVGDPRA TREGELPVHK RKWQAGEKIM YTLVSVPHGN
DIASLFELDA TTLQRADCLV PRNSYVRLRH LCTNTWVTST SIPIDTEEER PVMLKIGTCQ
TKEDKEAFAI ISVPLSEVRD LDFANDANKV LASTVKKLEY GTITQNERRF VTKLLEDLIF
FVAGVANNGQ EVLDVVVTKP NRERQKLMRE QNILAQIFGI LKAPFKDKAG EGSMLRLEDL
GDQRYAPYKY ILRLCYRVLR HSQQDYRKNQ EYIAKHFCVM QSQIGYDILA EDTITALLHN
NRKLLEKHIT AKEIETFVNL LRRNREPRFL DYLSDLCVSN TTAIPVTQEL ICKFMLSPGN
ADILIQTKLV SMQMDNPLEC SVLQDDMDEE EVWLYWIDSN KEPHGKAIRH LAQEAKEGTK
ADLEVLTYYR YQLNLFARMC LDRQYLAINQ ISTQLSVDLI LRCMSDESLP FDLRASFCRL
MLHIHVDRDP QETVVPVKYA RLWTEIPTKI SIHDYDSFTD SSRDEMKRKF ALTMEFVEEY
LKEVVNQPFP FGDKEKNKLT FEVVHLARNL IYFGFYSFTE LLRLTRTLLA ILDIVQSPMS
SYLERLSRFQ DGGNNVMRTI HGVGEMMTQM VLSRGSILPI AIPDVPAGLH SSKQGGAIDN
EDITVMDTKL KIIEILQFIL SVRLDYRISY MLSIYKREFG DQGNSIENST VSPPELLPPS
VGAPDIDEIA AQAETMFAGS KEKNPVELDD EGGRTFLRVL IHLIMHDYPP LLSGALQLLF
KHFSQRAEVL QAFKQVQLLV SNQDVDNYKQ IKADLDQLRL TVEKSELWVE KSNSYESEEL
GDGQTKERKE QMNEEASILS PLQDGIKKPQ IDSNKANNYK IVREILIRLS RLCTQSKKGR
NQQQRLLKNM GAHSVVLDLL QIPYEKTDDK MNDIMTLAHT FLQNFCRGNP QNQILLHKKL
NLFLTPGLLE AETMRNIFMN NYHLCNEISD RVVQHFVHCV ETHGRHVEYL RFLQTIVKAD
GKYVKKCQDV VMTELVNGGE DVLIFYNDRA SFPVLLQMMS SERDRADESG PLAYHITLVE
LLAACTEGKN VYTEIKCNSL LPLDDIVRVV THEDCIPEVK IAYVNFVNHC YVDTEVEMKE
IYTSNHIWKL FENFLVDMAR VCNTTTDRKH ADTALEKYVT ESVMNIVSGF FNSPFSDNST
NLQTHQPVFI QLLQSAFRIY NCTWPNQTQK ASVESCIKTL AEVAKNRGMA IPVDLDSQVN
TLFLKAHSNM VQRAAMGWRI TARNGPKYKE ALGSPSLDYK TIIEKLQDVV ASLENQFSPM
LLAEFSVLVD VLHSPERLFP DGSDARIRCG AFMSKLINHT KKLMEKEEKL CMKILQTLRE
MLDKKESFGE QGSTLRKILL NRYFKGEHGS SLNGPLSVAY GKSVPAGAFS GQDSDKSGVS
ISEIQCLLDK EGASELVIDV IVSTKNDRIF SEGILLGIAL LEGGNTQIQN SFYKQLDMQK
KSEKFFKVLY DRMKTAQQEI RATVSVNTVD LGTKKKEEDY DSLSLPKRRV RDSQYHLKEG
MKGQLAEASS ATSKAYCVYR KEIDPDIDMV GSGVDNGTGE EKSAEESAAM SPVIAIMEPI
LRFLQLLCEN HNRELQNFLR NQNNKTNYNL VCETLQFLDC ICGSTTGGLG LLGLYINERN
VALVNQTLES LTEYCQGPCH ENQTCIATHE SNGIDIIIAL ILNDINPLGK YRMDLVLQLK
NNASKLLLAI MESRHDSENA ERILYNMRPA ELVDVIKTAF NQGLEGDNEE HGPEDQVSPK
AVGHNIYILA HQLARHNKAL QHMLKPGLDP EEGDEALKYY ANHTAQIEIV RHDRTMEQIV
FPVPNICEFL TKESMWRVFN STERDEQGSK VNHFFQQTED LYNEMKWQKK IRNNPALFWF
SRHISLWGSI SFNLAVFINL AVALFYPFGD DGDEGTLSPL FSVLLWIAVA VCTAMLFLLP
KPFGIRPFLV SVMLRSIYTI GLGPTLILLG AGNLWNKVVF LVSFVGNRGT FTRGYRAVIM
DMAFLYHVLY VIVCMLGLFV HEFFYSFLLF DLVYREETLL NVIKSVTRNG RSIILTAVLA
LILVYLFSII GFLFLKDDFI MEVDRLKNRT PDLGHGEIRT SPLTTMMDTC HTENCSMTVS
IPDEDDDDDA DVERACDTLL MCIVTVLNQG LRNGGGVGDV LRKPSKDEPL FAARVVYDLL
FYFIVIIIVL NLIFGVIIDT FADLRSEKQK KEEILKTTCF ICGLERDKFD NKTVSFEEHI
MSEHCMWHYL YFIVLVKVKD PTEYTGPESY VAQMIVEKNL DWFPRMRAMS LVSSEGENEQ
NEIRNLQDKL ECTMSLVKQL SGQLAELKEQ MTEQRKNKQR LGFLGSNGPH VNHHMSPH
//
