ID F7EXC7_ORNAN Unreviewed; 2646 AA.
AC F7EXC7;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 2.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=GCN1 activator of EIF2AK4 {ECO:0000313|Ensembl:ENSOANP00000024710.2};
GN Name=GCN1 {ECO:0000313|Ensembl:ENSOANP00000024710.2};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000024710.2, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000024710.2, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024710.2,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000024710.2}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000024710.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GCN1 family.
CC {ECO:0000256|ARBA:ARBA00007366}.
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DR STRING; 9258.ENSOANP00000024710; -.
DR Ensembl; ENSOANT00000024714.3; ENSOANP00000024710.2; ENSOANG00000015677.3.
DR eggNOG; KOG1242; Eukaryota.
DR GeneTree; ENSGT00940000153612; -.
DR HOGENOM; CLU_000504_2_3_1; -.
DR InParanoid; F7EXC7; -.
DR OMA; KYATQRG; -.
DR TreeFam; TF105398; -.
DR Proteomes; UP000002279; Chromosome 2.
DR Bgee; ENSOANG00000015677; Expressed in endometrium and 7 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0022626; C:cytosolic ribosome; IEA:Ensembl.
DR GO; GO:0060090; F:molecular adaptor activity; IEA:Ensembl.
DR GO; GO:0019887; F:protein kinase regulator activity; IBA:GO_Central.
DR GO; GO:0043539; F:protein serine/threonine kinase activator activity; IEA:Ensembl.
DR GO; GO:0170011; F:stalled ribosome sensor activity; IEA:Ensembl.
DR GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:0140469; P:GCN2-mediated signaling; IEA:Ensembl.
DR GO; GO:0006417; P:regulation of translation; IBA:GO_Central.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 6.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR23346:SF7; EIF-2-ALPHA KINASE ACTIVATOR GCN1; 1.
DR PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 5.
DR PROSITE; PS50077; HEAT_REPEAT; 4.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000002279};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1337..1573
FT /note="TOG"
FT /evidence="ECO:0000259|SMART:SM01349"
FT REPEAT 1591..1629
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1633..1671
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1753..1789
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 1981..2018
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 2646 AA; 288928 MW; 87D66208C1A90D87 CRC64;
MAADTQVSET LKRFAVKVTT ASVKERREIL NDLGKCVAGK DLPEGAVKGL CKLFCLTLHR
YRDAASRRAL QSAIQRLAEA QPEATAKNLL QSLQSSGIGC KAGVPSKSSG SAALLALSWT
CLLVRVVFPT RAKRQGETWK KLVEVQCLLL LEVLGGSHKH AVDGAVKKLN RLWKEDPGLV
DQYLAVILSL EPNQNYAGML GLLVQFCTGQ KEMDAVNRHK GALLEFYVKN ILMSKTKPQK
HLLAHCAPLL RYVSHSEFKD QVLPVLQKSL LRSPENVIGS QLKSNSAQLM EEAVVALRNL
ARQCSDSSAV ESLARHLFAI LGGSEGKLTV VAQKMSVLSG IGSFSHHVVS GSSSQALNGT
VAELFVPFLQ QEVHEGTLVH AVSVLGLWCS RFSTEVPNKL IEWFKKAFSL KTSTSAVRHA
YLQCMLLSFR GDTLLQGMVL LPLLIQAVEK AGSQSTQVSA VTEGVAAALL ICRLSAVDVQ
AEAKLSGFWQ LIVDEKKQIF TSEKFLLLAS EDAMCTVLQL AERLLLDQAH RLPGSKVRQY
HRALAAVLLS RPWHVRRQAQ QTVRKLLSSL GGFRLAYGLL EELKAVLNSH KVLPSEALWA
ESGEVSESGK AYVAPRVLQE TLCVISGVPG LESDLTETER LAQEMLIITH HPSVVAVQSG
LWPSLLARMK LNPTDFITKH LDQILPRITS RAPLNQSSMN AMGSLSILSP SRVLPQLIGT
ITASVRNPAL CQVTREEFAV MQTPAGELYD KSIIQSAQQD SMKKANMKRE NKAYSFKEQI
IELELKEEIK KKKGIKEEVQ LTSKQKEMMQ AQLDKEAQIR RRLQELDGEL EAALGLLETI
LSKNPPGLTQ YIPVLVGSFL PLLNSPLAAP RIKGPFLALP GCVMSGRLKT LGTLVSHVTL
RLLKPECALD KSWCQEELPA ATKRAVNLLH AQTVPNRTGK GEPGASPLSA PAFSLVFPFL
KMVLTETSNQ SEEAEQLRVQ ILQILTVHAQ LRSSPKSKSV LVDENGPELL PRTDMLLLLT
RLVGTGSPHL QVLATNALTA LCAGSSGEAG CAFAEQEEVD VLLRALQSPC SNVRDAALRG
LSELQLVLPT PDGDEENGLN LLRRLWVVKF DVEEEIRKPA ERLWESMGLE LQPTLCSLLI
EDVIHPEEAV RQAGASALSH AVALYRRQAA QVMGRLMEIY QAKLYRPPPI LDALGRVISE
SPPDQWEARC GLALALNKLS EYLDSSQVKP LFQFFVPDAL NDRRPEVRKC MLDAAIATLN
THGKENVNSL LPVFEEFLKD APNDASYDAV RQSVVILMGS LAKHLDKSDP KVKPIVAKLV
AALSTPSQQV QESVASCLPP LVPAIKDDAG GMIQKLMQLL LESEKYAERR GAAYGLAGLV
KGLGILSLKQ QEMMTTLTDA IQDKKNFRRR EGALFAFEML CSMLGKLFEP YVVHVLPHLL
LCFGDGNQYV REAADDCAKA VMSNLSAHGV KLVLPSLLAA LEEESWRTKA GSVELLGAMA
YCAPKQLSSC LPNIVPKLTE VLTDSHVKVQ KAGQQALRQI GSVIRNPEIL AIAPVLLDAL
TDPSRKTQKC LQTLLDTKFV HFIDAPSLAL IMPIVQRAFQ DRSTDTRKMA AQIIGNMYSL
TDQKDLAPYL PSVTPGLKAS LLDPVPEVRT VSAKALGAMV KGMGESCFED LLPWLMETLT
YEQSSVDRSG AAQGLAEVMA GLGVEKLEKL MPEIVATASK VDIAPHVRDG YIMMFNYLPI
TFGDKFTPYV GPIIPCILKA LADENEFVRD TALKAGQRII SMYAETAIAL LLPQLEQGLF
DDLWRIRFSS VQLLGDLLFH ISGVTGKMTT ETASEDDNFG TAQSNKAIIS ALGVERRNRV
LAGLYMGRSD TQLVVRQASL HVWKIVVSNT PRTLREILPT LFGLLLGFLA STCSDKRTIA
ARTLGDLVRK LGEKILPEII PILEEGLRSE KSDERQGVCI GLSEIMKSTS RDAVLFFSES
LVPTARKALC DPLEEVREAA AKTFEQLHST IGFQALEDIL PFLLKQLDDR EMSEFALDGL
KQVMAVKSRV VLPYLVPKLT SPPVNTRVLA FLSTVAGDAL TRHLGVILPA VMSALKEKLG
TGHEQLEVAN CQAVILSVED DAGQRIIIED LLEATRSPEV GMRQAAAMIL NIYCSKSKAD
YTGHLRGLVS GLIRLFNDAN GVVLDESWDA LNSITKKLDA GNQLALIEDL HRDIRMVGND
AKGEHVPGFC IPKKGVTSIL PVLREGVLAG NPEQKEEAAR ALGLVIRLTS AEALKPSVVS
ITGPLIRILG DRFSWNVKVA LLETLSLLLA KVGIALKPFL PQLQTTFTKA LQDPNRAVRL
KAADALGKLI AIHVKVDPLF TELLNGIRTS EDSGVRDTML QALRFVTRGA GARVDAAIRK
NITTALLGML GHDEDATRMA SAGCLGELCA FLAEEELGAV LQQHLLADVS GIDWMVRHGR
SLALAVAVNV APGRLCNPKY GPGVQEMILS HAAADRIPIA VSGVRGMGFL MKHHVGAEGG
HLPGKLSSFF IKCLQNPSSD IRLVAEKMIW WANRDRLPPL DPQVIKPIVK ALLDNTKDKN
PSVRAYSDQA IVNLLKMRQG EAVFQAVSKI LDAASLELLN ESCRRSLKKL AGQADSLEQI
DDTILT
//
