ID F7F427_ORNAN Unreviewed; 245 AA.
AC F7F427;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 09-JAN-2013, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=Spindle and kinetochore-associated protein 1 {ECO:0000256|ARBA:ARBA00017140};
GN Name=SKA1 {ECO:0000313|Ensembl:ENSOANP00000012911.3};
OS Ornithorhynchus anatinus (Duckbill platypus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Monotremata; Ornithorhynchidae; Ornithorhynchus.
OX NCBI_TaxID=9258 {ECO:0000313|Ensembl:ENSOANP00000012911.3, ECO:0000313|Proteomes:UP000002279};
RN [1] {ECO:0000313|Ensembl:ENSOANP00000012911.3, ECO:0000313|Proteomes:UP000002279}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000012911.3,
RC ECO:0000313|Proteomes:UP000002279};
RX PubMed=18464734; DOI=10.1038/nature06936;
RA Warren W.C., Hillier L.W., Marshall Graves J.A., Birney E., Ponting C.P.,
RA Grutzner F., Belov K., Miller W., Clarke L., Chinwalla A.T., Yang S.P.,
RA Heger A., Locke D.P., Miethke P., Waters P.D., Veyrunes F., Fulton L.,
RA Fulton B., Graves T., Wallis J., Puente X.S., Lopez-Otin C., Ordonez G.R.,
RA Eichler E.E., Chen L., Cheng Z., Deakin J.E., Alsop A., Thompson K.,
RA Kirby P., Papenfuss A.T., Wakefield M.J., Olender T., Lancet D.,
RA Huttley G.A., Smit A.F., Pask A., Temple-Smith P., Batzer M.A.,
RA Walker J.A., Konkel M.K., Harris R.S., Whittington C.M., Wong E.S.,
RA Gemmell N.J., Buschiazzo E., Vargas Jentzsch I.M., Merkel A., Schmitz J.,
RA Zemann A., Churakov G., Kriegs J.O., Brosius J., Murchison E.P.,
RA Sachidanandam R., Smith C., Hannon G.J., Tsend-Ayush E., McMillan D.,
RA Attenborough R., Rens W., Ferguson-Smith M., Lefevre C.M., Sharp J.A.,
RA Nicholas K.R., Ray D.A., Kube M., Reinhardt R., Pringle T.H., Taylor J.,
RA Jones R.C., Nixon B., Dacheux J.L., Niwa H., Sekita Y., Huang X., Stark A.,
RA Kheradpour P., Kellis M., Flicek P., Chen Y., Webber C., Hardison R.,
RA Nelson J., Hallsworth-Pepin K., Delehaunty K., Markovic C., Minx P.,
RA Feng Y., Kremitzki C., Mitreva M., Glasscock J., Wylie T., Wohldmann P.,
RA Thiru P., Nhan M.N., Pohl C.S., Smith S.M., Hou S., Nefedov M.,
RA de Jong P.J., Renfree M.B., Mardis E.R., Wilson R.K.;
RT "Genome analysis of the platypus reveals unique signatures of evolution.";
RL Nature 453:175-183(2008).
RN [2] {ECO:0000313|Ensembl:ENSOANP00000012911.3}
RP IDENTIFICATION.
RC STRAIN=Glennie {ECO:0000313|Ensembl:ENSOANP00000012911.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SKA1 family.
CC {ECO:0000256|ARBA:ARBA00006836}.
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DR AlphaFoldDB; F7F427; -.
DR STRING; 9258.ENSOANP00000012911; -.
DR Ensembl; ENSOANT00000012913.4; ENSOANP00000012911.3; ENSOANG00000008124.4.
DR eggNOG; KOG4832; Eukaryota.
DR GeneTree; ENSGT00940000166139; -.
DR HOGENOM; CLU_096842_0_0_1; -.
DR InParanoid; F7F427; -.
DR OMA; PTGMRED; -.
DR TreeFam; TF324442; -.
DR Proteomes; UP000002279; Chromosome 3.
DR Bgee; ENSOANG00000008124; Expressed in fibroblast and 8 other cell types or tissues.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:0000940; C:outer kinetochore; IBA:GO_Central.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IBA:GO_Central.
DR GO; GO:0007059; P:chromosome segregation; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0031110; P:regulation of microtubule polymerization or depolymerization; IBA:GO_Central.
DR CDD; cd12958; SKA1_N; 1.
DR Gene3D; 6.10.250.1370; -; 1.
DR Gene3D; 1.10.10.1890; Ska1 microtubule binding domain-like; 1.
DR InterPro; IPR009829; SKA1.
DR InterPro; IPR042031; SKA1-MBD.
DR PANTHER; PTHR28573; SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR28573:SF1; SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 1; 1.
DR Pfam; PF07160; SKA1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000002279}.
FT REGION 93..116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 53..90
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 94..108
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 245 AA; 28210 MW; 46D0F98C68E3B77E CRC64;
MGSSDLEDLC SHINGKISNI KKTLQLRNIG QEPSLKAVLS KIGYEMSLLN EFLNKLELEV
QRQEHLRNSL KELQESIEGD YKEVEHLKEN VPPHLPQVNQ SCSAGPNVKT EEQDPVAEPG
HTKKLLKQQK MIKEALLITA AEFNTVPAYM KSRLTYCQIN DVVQEINKAV TSKYKILQQP
KKSMSSAVRN LYHRFLEEET KDTKGQFFIV EADIKEFTNL KLDKRFHVIL NILRHCRRLS
EVRGK
//
