ID F7F6I3_CALJA Unreviewed; 364 AA.
AC F7F6I3;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 25-MAY-2022, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Growth differentiation factor 3 {ECO:0000313|Ensembl:ENSCJAP00000009876.3};
GN Name=GDF3 {ECO:0000313|Ensembl:ENSCJAP00000009876.3};
OS Callithrix jacchus (White-tufted-ear marmoset).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC Callitrichinae; Callithrix; Callithrix.
OX NCBI_TaxID=9483 {ECO:0000313|Ensembl:ENSCJAP00000009876.3, ECO:0000313|Proteomes:UP000008225};
RN [1] {ECO:0000313|Ensembl:ENSCJAP00000009876.3}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Warren W., Ye L., Minx P., Worley K., Gibbs R., Wilson R.K.;
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCJAP00000009876.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR AlphaFoldDB; F7F6I3; -.
DR STRING; 9483.ENSCJAP00000009876; -.
DR Ensembl; ENSCJAT00000010434.5; ENSCJAP00000009876.3; ENSCJAG00000005406.5.
DR eggNOG; KOG3900; Eukaryota.
DR GeneTree; ENSGT00940000162534; -.
DR HOGENOM; CLU_020515_4_0_1; -.
DR InParanoid; F7F6I3; -.
DR OMA; LDVAKDW; -.
DR OrthoDB; 2912454at2759; -.
DR TreeFam; TF351789; -.
DR Proteomes; UP000008225; Chromosome 9.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0007492; P:endoderm development; IEA:Ensembl.
DR GO; GO:0001654; P:eye development; IEA:Ensembl.
DR GO; GO:0048859; P:formation of anatomical boundary; IEA:Ensembl.
DR GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
DR GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
DR GO; GO:0030514; P:negative regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0045605; P:negative regulation of epidermal cell differentiation; IEA:Ensembl.
DR GO; GO:0045662; P:negative regulation of myoblast differentiation; IEA:Ensembl.
DR GO; GO:0030903; P:notochord development; IEA:Ensembl.
DR GO; GO:0045600; P:positive regulation of fat cell differentiation; IEA:Ensembl.
DR GO; GO:0090009; P:primitive streak formation; IEA:Ensembl.
DR GO; GO:0010453; P:regulation of cell fate commitment; IEA:Ensembl.
DR GO; GO:0002021; P:response to dietary excess; IEA:Ensembl.
DR GO; GO:0001501; P:skeletal system development; IEA:Ensembl.
DR GO; GO:0032525; P:somite rostral/caudal axis specification; IEA:Ensembl.
DR CDD; cd13764; TGF_beta_GDF1_3_like; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF38; GROWTH_DIFFERENTIATION FACTOR 3; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000008225};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..364
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5035254233"
FT DOMAIN 247..364
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
SQ SEQUENCE 364 AA; 41222 MW; A02C897162AC643C CRC64;
MGPFLPDLAF SFLLTLALGQ AVQFQEYVFL QFLDLDKAPS PQKFQPVPYI LKKIFQDREA
AATTGVSQDL CYVKELGVRG NVLRFLPDQG FFLYPKKPFQ ASSCLQKLLY FNLSAIKERE
QLTLAQLGLD LGPSSYYNLG PELELALFLV QEPHVWGQFT PKPGKIFALQ SVPWPQGALR
FNLLDVAKDW NDNPQKNFGL FLEILVKEDR DSGVNFQPED ACTRLRRSLH ASLLVVTLNS
DQCHPSRKRR AAIPVPKASC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGDCPFS
LTVSLNSSNY AFMQALMQAV DPETPQAVCI PSKLSPISML YQDNNDNVIL RHYEDMVVDE
CGCG
//
