ID F7FC08_MACMU Unreviewed; 691 AA.
AC F7FC08;
DT 27-JUL-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO1B7 {ECO:0000313|Ensembl:ENSMMUP00000009548.4};
OS Macaca mulatta (Rhesus macaque).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000009548.4, ECO:0000313|Proteomes:UP000006718};
RN [1] {ECO:0000313|Proteomes:UP000006718}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=17573 {ECO:0000313|Proteomes:UP000006718};
RX PubMed=17431167; DOI=10.1126/science.1139247;
RA Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
RA Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C., Wilson R.K.,
RA Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W., Hardison R.C.,
RA Makova K.D., Miller W., Milosavljevic A., Palermo R.E., Siepel A.,
RA Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
RA Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y., Dinh H.H.,
RA Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T., Godfrey J.,
RA Hawes A.C., Hernandez J., Hines S., Holder M., Hume J., Jhangiani S.N.,
RA Joshi V., Khan Z.M., Kirkness E.F., Cree A., Fowler R.G., Lee S.,
RA Lewis L.R., Li Z., Liu Y.-S., Moore S.M., Muzny D., Nazareth L.V.,
RA Ngo D.N., Okwuonu G.O., Pai G., Parker D., Paul H.A., Pfannkoch C.,
RA Pohl C.S., Rogers Y.-H.C., Ruiz S.J., Sabo A., Santibanez J.,
RA Schneider B.W., Smith S.M., Sodergren E., Svatek A.F., Utterback T.R.,
RA Vattathil S., Warren W., White C.S., Chinwalla A.T., Feng Y., Halpern A.L.,
RA Hillier L.W., Huang X., Minx P., Nelson J.O., Pepin K.H., Qin X.,
RA Sutton G.G., Venter E., Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P.,
RA Jones S.M., Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L.,
RA Csuros M., Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H.,
RA Liu Y., Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
RA Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
RA Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
RA Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
RA Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J., Denby A.,
RA Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A., Marklein A.,
RA Nielsen R., Vallender E.J., Clark A.G., Ferguson B., Hernandez R.D.,
RA Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S., Pu L.-L., Ren Y.,
RA Smith D.G., Wheeler D.A., Schenck I., Ball E.V., Chen R., Cooper D.N.,
RA Giardine B., Hsu F., Kent W.J., Lesk A., Nelson D.L., O'brien W.E.,
RA Pruefer K., Stenson P.D., Wallace J.C., Ke H., Liu X.-M., Wang P.,
RA Xiang A.P., Yang F., Barber G.P., Haussler D., Karolchik D., Kern A.D.,
RA Kuhn R.M., Smith K.E., Zwieg A.S.;
RT "Evolutionary and biomedical insights from the rhesus macaque genome.";
RL Science 316:222-234(2007).
RN [2] {ECO:0000313|Ensembl:ENSMMUP00000009548.4}
RP IDENTIFICATION.
RC STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000009548.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR RefSeq; XP_001097704.1; XM_001097704.3.
DR AlphaFoldDB; F7FC08; -.
DR SMR; F7FC08; -.
DR PaxDb; 9544-ENSMMUP00000011258; -.
DR Ensembl; ENSMMUT00000010175.4; ENSMMUP00000009548.4; ENSMMUG00000020443.4.
DR VEuPathDB; HostDB:ENSMMUG00000020443; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01080000257336; -.
DR OrthoDB; 2874223at2759; -.
DR TreeFam; TF317540; -.
DR Proteomes; UP000006718; Chromosome 11.
DR Bgee; ENSMMUG00000020443; Expressed in liver and 20 other cell types or tissues.
DR ExpressionAtlas; F7FC08; baseline.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR Gene3D; 3.30.60.30; -; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF82; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 1B1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000006718};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 29..48
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 68..89
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 96..117
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 207..230
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 258..279
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 337..356
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 376..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 409..428
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 534..558
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 570..591
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 624..646
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 30..647
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 453..508
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 691 AA; 76315 MW; 3AA46D6CA08C5212 CRC64;
MDQNKHLDKT AEAQSSENKK TRHCNGLKMF LAALALSFIA KALGAVVMKS SIIHIERRFE
ISSSLVGFID GSFEIGNLLV IVFVSYFGSK LHRPKLIGIG CFIMGIGGVL TALPHFFMGY
YRYSKEINID SSENSTSTLS TCLINQIVSL NRTSPEIVGK GCVKESGSYM WMYVFMGNML
RGIGETPIVP LGLSYMDDFA KEGHSSLYLG ILNAIAMIGP IIGFTLGSLF SKMYVDIGSV
DLSTVRITPN DSRWVGAWWL NFLVSGLFSI ISSIPFFFLP QTPNKPQKER KASLSLPVLE
TNDGKSQTAN LTSRGKKITK NVTGFFRSFK SILTNPLYVV FVLLTLLQIS SYIGGFTYVF
KYVEQEYGQP SSKTNVLLGI VTLPIFASGM FLGGYIIKKF KLNPIGIAKF SFFTTVMSLF
FYLLYFFILC ENKSVAGLTM TYDGNNPVTS HRDVPLSYCN SDCNCDESQW EPVCGNNGIT
YISPCLAGCK SSSGNKKSIV FHNCSCLEVT GLQNRNYSAH LGECPRSDAC LTKFYFFVAI
QVLNLFFSAL GGTSYFMLMV KIVQPELKSL ALGFHSMVIR ALGGILAPIY FGALIDTTCM
KWSTNNCGTR GSCRIYNSTL FSKVYLGLSS VLRVSSLVLY IILIYAMKKK FQEKDANASE
NGSVMDEANL ESLNNNKHFV PSAGADSETH Y
//
